目的：探讨硝普钠控制性降压在脊柱手术中的临床应用。方法：72例拟在全麻下行脊柱手术患者随机分成两组：观察组（硝普钠组，n=36）与对照组（n=36）。所有患者均静脉注射咪唑安定0.1mg·kg-1、丙泊酚2mg·kg-1、芬太尼2μg·kg-1和采用预注给药的阿曲库铵进行气管内插管，以异氟醚或氨氟醚、阿曲库铵和芬太尼维持麻醉。观察组在手术进入椎体前3～5min由输液泵输入001％硝普钠，控制速度使收缩压维持于60～80mmHg的范围。记录两组出血量、输血量、输液量、手术时间，术后1h血红蛋白与术前血红蛋白等。结果：两组患者基本情况、手术类型、晶体液、胶体液输入量无统计学差异；观察组术中失血量和输血量均明显少于对照组，且手术时间明显缩短；两组术后1h血红蛋白与术前比较均有所下降，但差异无显著性。结论：脊柱手术中采用硝普钠控制性降压效果安全、可靠，可明显减少术中出血量及输血量，缩短手术时间。
To investigate changes of serum nitric oxide (NO) levels and therapeutic effects of sodium nitroprusside (SNP) in acute hemorrhagic necrotizing pancreatitis (AHNP) in rats, one hundred and twenty Wistar rats were divided into three groups randomly (forty in each group) animal models of AHNP group were produced by retrograde injection of 5% sodium taurocholate into pancreatobiliary duct.In the treatment group SNP (0.05mg/100g) was injected intraperitoneally after AHNP models established and then repeated three hours later. In the control group only retrograde injection of normal saline (0.5ml) into pancreatobiliary duct was performed. The results showed: compared with the treatment group, serum NO and SOD levels were significantly lower in AHNP group (Ｐ＜0.05); serum amylase levels and pancreatic indexes were markedly higher in AHNP (Ｐ＜0.01 and Ｐ＜0.05 respectively);the mortality in 24 hours was significantly higher and survival time was significantly shorter in AHNP group (Ｐ＜0.01).Pathologic changes of pancreas were significantly severe in AHNP group. From the above results we can draw the conclusion that NO plays an important role in the pathogenesis of AHNP and SNP has therapeutic effects on AHNP in rats.
【摘要】 目的 Ⅲ型主动脉夹层非体外循环腔内支架隔离术在围手术期应用硝普钠控制性降压易导致精神失常，总结相关护理经验。 方法 2009年7月-2010年2月确诊Ⅲ型主动脉夹层动脉瘤患者36例，围手术期应用硝普钠控制性降压，均采用非体外循环主动脉腔内隔离术治疗，排除手术、麻醉等因素所致脑损伤而产生的术后精神异常。 结果 有5例出现不同程度精神失常，经加用口服降压药，减少硝普钠泵入剂量，缩短硝普钠使用时间，经过精心治疗及护理，患者精神异常症状逐渐减轻直至消失。 结论 长期、大剂量应用硝普钠易导致精神失常，需加强护理，及时发现，及时处理。【Abstract】 Objective To summarize the nursing experiences for mental disorders caused by sodium nitroprusside used to cure hypertension in patients receiving off-pump intervention surgery for DeBackey Ⅲ aortic dissection. Methods From July 2009 to February 2010, 36 patients were diagnosed to have DeBackey Ⅲ aortic dissection in our department. All patients received off-pump intervention surgery. We used sodium nitroprusside to control hypertension during the operation. Mental disorders caused by brain damage from surgery, anesthesia and other factors were ruled out. Results Five patients suffered from psychiatric disorders. Oral antihypertensive drugs were used, and we reduced the dose and shortened the time of using sodium nitroprusside. After intensive treatment and care, the symptoms of mental disorders alleviated and disappeared. Conclusion Long-term and large dose of sodium nitroprusside can easily lead to mental disorders, which requires intensive care, timely detection and treatment.