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find Keyword "神经内分泌癌" 10 results
  • 原发性肝脏神经内分泌癌的围手术期护理

    【摘要】 目的 通过对3例原发性肝脏神经内分泌癌患者的护理,总结该疾病的围手术期护理要点。 方法 2008年11月-2010年6月,在了解及掌握该疾病的原因、临床表现及治疗手段基础上,对3例原发性肝脏神经内分泌癌患者进行精心护理,重点做好术前心理疏导和术后并发症的观察护理。 结果 3例患者术后恢复良好,未发生并发症,顺利出院。 结论 做好原发性肝脏神经内分泌癌患者围手术期护理能有效预防其并发症的发生。

    Release date:2016-09-08 09:52 Export PDF Favorites Scan
  • Three Cases Reports of Primary Hepatic Neuroendocrine Carcinoma

    Objective To summarize the diagnosis and treatment for primary hepatic neuroendocrine carcinoma. Methods The clinicopathologic data of three patients with primary hepatic neuroendocrine carcinoma from June 2010 to June 2011 in this hospital were analyzed retrospectively. Results Three cases were difficult to diagnose primary hepatic neuroendocrine carcinoma before operation. All the treatments were resection. Three patients were diagnosed as neuroendocrine carcinoma by pathology and immunohistochemistry after operation. All of them were treated by octreo-tide after operation and discharged from hospital successfully. There was no relapse one year later. At present, 3 patients were still continue to follow-up. Conclusions The diagnosis of primary hepatic neuroendocrine carcinoma is very difficult before operation, the assessment of treatment and curative effect is exploring.

    Release date:2016-09-08 10:34 Export PDF Favorites Scan
  • Clinicopathologic Features and Surgical Treatment of Pancreatic Neuroendocrine Carcinoma

    Objective To investigate the clinicopathologic features and effect of surgical treatment of pancreatic neuroendocrine carcinoma(PNEC). Methods Clinical data of 31 patients with PNEC treated from Jan. 2008 to Mar. 2012 in our hospital were analyzed,and the expressions of protein CgA,Syn,CD56,CK,VEGF,and Ki-67 were detected by immunohistochemical method. The differences of survival rate and time between radical excision group and palliative surgery group were analyzed by log-rank test. Results Of the 31 patients,22 patients received radical resection and 9 patients received palliative surgery. The positive expression rate of protein CgA,Syn,CD56,CK,and VEGF was 64.52%(20/31),100%(31/31),77.42%(24/31),90.32%(28/31),90.32%(28/31),respectively. According to the percentage of Ki-67 positive cells, 14(45.16%) patients expressed less than 3%,7(22.58%) patients expressed between 3% and 20%, and 10(32.26%)patients expressed more than 20%. The survival rate and time of radical resection group were significantly higher and longer than palliative surgery group(P<0.001). Conclusions PNEC is a high potential malignancy and demonstrates aggressive biological behavior. Radical resection can improve the prognosis of patients with PNEC.

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
  • Imaging of Pancreatic Neuroendocrine Carcinoma

    Objective To evaluate the imaging features of pancreatic neuroendocrine carcinoma (PNEC). Methods The imaging data of 7 patients with PNECs proved by surgery and pathology in West China Hospital of Sichuan University from Jul. 2007 to Dec. 2012 were retrospectively analyzed. The boundary, density, and strengthening features of tumor were observed. Results Seven tumors were found in all patients with 2 in pancreatic head, body, and tail, respectively. There was 1 tumor in pancreatic body and tail too. Five tumors were with unclear boundary. Five tumors had hypodense enhancement and 2 had isodense enhancement. Two cases had distal pancreatic duct dilation. None of them had liver metastases or lymph node involvement. Conclusion PNEC has certain characteristics on imaging. It is difficult to distinguish diagnosis from pancreatic cancer.

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
  • 1例肝外胆管神经内分泌癌病例报道及文献复习

    目的结合文献分析并总结肝外胆管神经内分泌癌的临床病理特点、诊断和治疗。 方法回顾性分析我院收治的1例肝外胆管神经内分泌癌的临床病理特征并结合国内外文献进行分析总结。 结果本组1例患者为男性,58岁,以右上腹间断胀痛为主诉,影像学检查示胆总管下端占位并胆管梗阻,手术治疗,术后病理诊断:胆总管末端神经内分泌癌。患者术后恢复顺利。半年后复查,肿瘤多发转移,再1个月后患者因肿瘤广泛转移而死亡。查阅国内外文献,共检索到27篇共27例已报道病例,本病临床表现与一般胆管癌相同,主要表现为黄疸和上腹部疼痛不适。治疗以手术治疗为主,部分患者辅以化疗或放疗,术后生存时间1~45个月。 结论肝外胆管神经内分泌癌是罕见的胆管恶性肿瘤,临床表现以腹痛、黄疸常见。影像学检查可定位但无法定性,目前仅能通过病理及免疫组织化学确诊。治疗以手术为主,但疗效较差。

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  • 肺大细胞神经内分泌癌六例临床分析

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  • Clinical Features and Prognosis of Neuroendocrine Carcinoma of Esophagus: 41 Cases Analysis

    ObjectiveTo explore the clinical features and the prognostic factors of neuroendocrine carcinoma of the esophagus. MethodsWe retrospectively analyzed clinical data of 41 cases of neuroendocrine carcinoma of the esophagus admitted in the First Affiliated Hospital of Nanjing Medical University between March 2008 and March 2014. There were 37 males and 4 females at a mean age of 61.1±7.9 years (ranged from 40 to 79 years). All patients underwent surgical resection and lymph node dissection. ResultsNo severe complications occurred during the perioperative period, and no death occurred during the period of hospitalization.Thirteen patients received postoperative chemotherapy and radiotherapy. Eleven patients received simple postoperative chemotherapy. One patient received postoperative radiotherapy. The remaining 16 patients did not receive any special treatment. The patients were followed up for 6 to 61 (24.0±13.6)months. Twenty-two patients survived, the other 19 patients died. The 1-year, 2-year, 3-year, 4-year, and 5-year survival rate was 80.49%, 39.02%, 21.95%, 7.32%, and 4.88%, respectively. The median survival of single surgical treatment and postoperative comprehensive treatment was 12.0 months and 25.0 months, respectively. The median survival of T2-T4 and T1 was 20.0 months and 37.5 months, respectively. The difference was statistically different (P<0.05). Cox regression analysis showed that the depth of tumor invasion, postoperative adjuvant chemotherapy and radiotherapy were independent factors of prognosis (P<0.05). ConclusionsNeuroendocrine carcinoma of the esophagus is rare and with a high degree of malignancy. It is expected to increase the long-term survival rate after surgical and postoperative comprehensive treatment.

    Release date:2016-10-19 09:15 Export PDF Favorites Scan
  • Multiple neuroendocrine carcinoma: a case report

    ObjectiveTo study the diagnosis and treatment of multiple neuroendocrine carcinoma.MethodClinical data of a case of multiple neuroendocrine carcinoma was retrospective analyzed.ResultsAfter discussion by a multidisciplinary team (MDT), the patient was diagnosed as multiple neuroendocrine carcinoma with late clinical stage and inoperable. Chemotherapy and radiotherapy were given, which showed significant effects, and the patient died after 1 year of follow-up.ConclusionIn the clinical diagnosis and treatment of patients with multiple neuroendocrine carcinoma, MDT cooperative treatment model should be adopted to provide a better treatment program.

    Release date:2020-08-19 12:21 Export PDF Favorites Scan
  • Effect of surgical treatment on prognosis in patients with rectal small cell neuroendocrine carcinoma based on SEER database

    Objective To explore the value of surgical treatment in rectal small cell neuroendocrine carcinoma (RSCC). Method The clinical data of patients with pathologically diagnosed as RSCC from 2000 to 2019 were extracted from the Surveillance, Epidemiology and End Results (SEER) database, to explore the effect of surgical treatment on cancer-specific survival (CSS) and overall survival (OS). Results A total of 348 cases were included with the median follow-up of 8 months (IQR: 3–16 months). Of the 101 patients in the operation group, 84 died (83.2%), including 56 tumor-related deaths (55.4%). Of the 247 patients in the non-operation group, 215 died (87.0%), including 131 tumor-related deaths (53.0%). The estimated 1-year OS of the operation group and the non-operation group were 49.6% and 34.4%, respectively, and the estimated 1-year CSS of those were 62.2% and 49.2%, respectively. There were significant differences between the two groups (both P<0.05). Results of multivariate prognostic analysis by Cox proportional hazard model showed that differentiation, SEER stage, receiving operative treatment or not, receiving chemotherapy or not, and receiving radiotherapy or not were independent influencing factors for OS, and SEER stage, receiving operative treatment or not, receiving chemotherapy or not, and receiving radiotherapy or not were independent influencing factors for CSS (all P<0.05). The OS [RR=0.61, 95%CI was (0.45, 0.81), P<0.001] and CSS [RR=0.67, 95%CI was (0.47, 0.95), P=0.025] in RSCC patients were significantly improved by surgical treatment. Conclusion Surgical treatment can improve the OS and CSS in RSCC patients.

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  • 程序性死亡受体配体 1 阴性晚期肺大细胞神经内分泌癌免疫治疗联合放疗完全缓解一例

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