west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "穆军升" 20 results
  • Research Progress of Relationship between Mitochondrial Fusion Protein 1,Mitochondrial Fusion Protein 2 and Physiological Function of Cardiomyocyte

    The main function of mitochondrial fusion protein 1 (Mfn1) and mitochondrial fusion protein 2 (Mfn2) was originally thought to be just regulating the fusion of mitochondrial outer membrane. But in recent years,many studies on these two proteins show that they are involved in many important cellular physiological processes including proliferation,apoptosis,necrosis and regulation of respiratory function and oxidative metabolism. There are many aspects of the influenceof Mfn1 and Mfn2 on cardiomyocyte,which have not been thoroughly studied yet,sometimes with even contradictoryconclusions. But these two proteins definitely have significant impact on the growth,development and physiological functionof cardiomyocyte. To investigate the function and mechanism of Mfn1 and Mfn2 in various physiological processes of cardiomyocyte is of great significance for in vitro studies of physiological functions of cardiomyocyte and technological development of myocardial tissue engineering and transplantation in vivo. This article mainly focuses on recent research progress of the influence of Mfn1 and Mfn2 on various physiological functions of cardiomyocyte.

    Release date:2016-08-30 05:47 Export PDF Favorites Scan
  • Research Progress of Myocardial Tissue Engineering Extracellular Matrix

    The establishing of myocardial tissue engineering techniques not only solve a series of issues that generate in cell and tissue transplantation after myocardial infarction, but also create a platform for selecting better materials and transplantation techniques. However, both experimental animal studies and recent clinical trials indicate that current transplantation techniques still have many defects, mainly including lack of suitable seed cells, low survival rate and low differentiation rate after transplantation. In this context, extracellular matrix (ECM), as myocardial tissue engineering scaffold materials, has gained increasing attention and become a frontier and focus of medical research in recent years. ECM is no longer merely regarded as a scaffold or a tissue, but plays an important role in providing essential signals to influence major intracellular pathways such as cell proliferation, differentiation and metabolism. The involved models of ECM can be classified into following types:natural biological scaffold materials, synthetic polymer scaffold materials and composite scaffold materials with more balanced physical and biological properties. This review mainly introduces research progress of ECM in myocardial tissue engineering and ECM materials.

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
  • P-选凝素与心肌缺血-再灌注损伤

    研究心肌缺血-再灌注损伤中P-选凝素(P-selectin)的重要作用.P-selectin是一种糖蛋白黏附因子, 存在于内皮细胞和血小板,并介导血小板、内皮细胞和多形核白细胞(PMNs)等之间的相互作用,且与一氧化氮有着密切的关系,形成了许多复杂的炎症病理过程,在心肌缺血-再灌注损伤中起到了关键的作用.特别是P-selectin与晚期再灌注损伤、血小板及心肌损伤中治疗作用、最新的P-selectin基因缺陷小鼠和糖尿病小鼠等的心肌缺血-再灌注损伤中表现的深入研究,使其在缺血-再灌注损伤中的重要性和复杂性显得更加突出.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • 先天性双冠状动脉-肺动脉瘘缝扎术后再通一例

    Release date:2016-08-30 05:49 Export PDF Favorites Scan
  • 80岁以上老年患者冠状动脉旁路移植术65例临床分析

    目的 总结80岁以上老年患者行冠状动脉旁路移植术(CABG)的临床经验,评价临床选择标准和手术疗效。 方法 回顾性分析2002年7月至2009年5月首都医科大学附属北京安贞医院65例年龄≥80岁老年患者行CABG或非体外循环冠状动脉旁路移植术(OPCAB)的临床资料,男54例,女11例;年龄80~99岁,平均年龄81.9岁。行CABG 2例,OPCAB 63例。 结果 手术死亡11例,手术死亡率16.9%,死于心力衰竭7例,呼吸衰竭3例,大出血1例。54例手术后恢复顺利,痊愈出院,治愈率83.1 %(54/65),心功能分级(NYHA) Ⅰ~Ⅱ级43例(79.6%);住重症监护室时间3.5±3.4 d,住院时间25.2±13.4 d。术后发生并发症23例(35.4%),包括脑卒中、循环衰竭、肾功能不全、心肌梗死、呼吸衰竭、开胸止血和胸腔积液等。上述并发症均经相应的处理治愈或好转。随访49例,随访时间10~38个月,治疗效果良好,心功能均达Ⅰ~Ⅱ级,生活质量较术前明显提高。失访5例。 结论 虽然80岁以上老年患者行CABG术后并发症发生率较高、住院时间长、手术死亡率高,但手术能使冠心病患者摆脱心脏疾病的痛苦,80岁以上老年患者行CABG是可行的。

    Release date:2016-08-30 05:57 Export PDF Favorites Scan
  • Risk Factors of Atrial Fibrillation after Coronary Artery Bypass Grafting

    Objective To analyze the preoperative risk factors of atrial fibrillation (AF) in patients with coronary artery disease after coronary artery bypass grafting (CABG). Methods From September 2007 to April 2008, the clinical information of 226 patients who underwent onpump coronary artery bypass grafting(CABG)or offpump coronary artery bypass grafting(OPCAB) was collected. The patients were divided into nonAF group and AF group according to whether AF lasted more than 5 mins in 3 days after operation. Ultrasonic cardiography (UCG) and clinical information of preoperation in two groups were analyzed. Results Twentyfour(10.6%) patients had AF after operation. There were more patients whose left atrial diameter gt;35 mm in AF group than that in nonAF group [41.7%(10)vs. 22.3% (45),χ2=4.380, P=0.036)], more patients had mitral regurgitation in AF group than that in nonAF group [37.5%(9) vs. 17.3% (35),χ2=5.568, P=0.018)], more patients had left main coronary artery involvement in AF group than that in nonAF group [33.3% (8) vs.12.4% (25),χ2=7.560,P=0.006], and patients in AF group were older than those in nonAF group [65.7±9.5 years vs. 60.1±10.1 years,t=-2.724,P=0.010]. In univariate analysis, in terms of preoperative clinical indexs such as the aged, mitral regurgitation, left atrial diameter, left mainm coronary artery involvement, and postoperative clinical indexs such as ventilatory time (χ2=4.190,P=0.040), electrocardiogram (ECG) monitoring time(χ2=5.948,P=0.015), hospitalization expense(χ2=4.110,P=0.043), there were significant differences between 2 groups. Conclusion Risk factors such as the aged, mitral regurgitation, left atrial diameter and left main coronary artery involvement are related to AF after CABG. Clinical index, ECG and echocardiography are helpful to predict AF, and can provide better prevention and treatment, and reduce the rate of AF.

    Release date:2016-08-30 06:05 Export PDF Favorites Scan
  • 体外循环与非体外循环冠状动脉旁路移植术临床分析

    目的 比较体外循环冠状动脉旁路移植术(on—pump CABG,on—pump)和非体外循环冠状动脉旁路移植术(off—pump CABG,off—pump)的临床应用效果。方法 回顾2003年12月-2005年1月间我院行冠状动脉旁路移植术(CABG)195例的临床资料,依据术中采用不同的手术方式分为on—pump组和off—pump组。并对两组患者的术前、术后临床资料、术后并发症发生情况进行分析。结果 两组患者术前一般临床资料比较差别无统计学意义;术后off—pump组发生并发症17例,on—pump组26例(P=0.000);off-pump组住院死亡2例,on—pump组死亡6例(P=0.025)。结论 在多支左主干病变中,off—pump和on—pump在再血管化的应用上无差别;off—pump后的心电图改变、死亡率和并发症发生率比on—pump患者低,但是合并瓣膜病或严重的3支血管病变、左主干病变、室壁瘤形成的患者更适宜采用on—pump,off—pump不能取代on—pump。

    Release date:2016-08-30 06:18 Export PDF Favorites Scan
  • eNOS基因转染预防静脉移植血管再狭窄

    摘 要: 目的 应用含牛内皮型一氧化氮合成酶(eNOS)基因重组腺病毒(Ad5CMVNOSⅢ)转染静脉移植血管、观察eNOS基因预防静脉移植血管再狭窄的作用。方法 将21只杂种犬分为3组,手术对照组、Ad5CMVLac—Z(含大肠杆菌β半乳糖苷酶基因重组腺病毒)对照组和Ad5CMVNOSⅢ干预组。在犬颈静脉、颈动脉旁路血管移植术中分别应用Ad5CMVNOSⅢ病毒液或Ad5CMVLac—Z病毒液常温浸泡法感染静脉移植血管30分钟,术后28天病理切片观测移植血管新内膜增生状况。结果 与正常犬颈外静脉相比,手术对照组、Ad5CMVLac—Z对照组和Ad5CMVNOSⅢ干预组颈外静脉移植血管内膜/中膜比较均有不同程度增加(P<0.05),但Ad5CMVNOSⅢ组内膜/中膜比显著低于另外2个对照组(P<0.05),新内膜增生明显减轻。结论 Ad5CMVNOSⅢ感染静脉旁路移植血管对预防再狭窄有一定作用。

    Release date:2016-08-30 06:31 Export PDF Favorites Scan
  • 体外培养人大隐静脉新内膜形成模型的建立

    目的 为了更好地研究静脉再狭窄的机制及预防治疗,建立一种人的大隐静脉体外培养模型,并对新内膜进行初步研究. 方法 取6例冠状动脉旁路移植手术患者大隐静脉,体外培养14天,常规病理学染色,图象分析; 通过α-平滑肌细胞骨架(α-actin)免疫组织化学染色方法检测内膜增生细胞,末端脱氧核苷酸转移酶介导的dUTP缺口末端标记(TUNEL)方法检测内膜凋亡细胞. 结果 培养的大隐静脉在14天后有新内膜形成和显著的中膜增厚,与正常血管相比差别具有显著性意义(P<0.01).新内膜细胞α-actin免疫组织化学染色结果呈阳性细胞,较正常血管内膜明显增多.在新内膜中荧光和核边聚分裂数目极少,与正常血管相比差别无显著性意义. 结论 在人的大隐静脉体外培养中有新内膜形成和中膜增厚,增生的细胞可能是肌成纤维细胞,故抑制肌成纤维细胞增生迁移的同时,促进凋亡将是静脉移植血管病变潜在的治疗方法.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • 主动脉瓣四叶畸形合并肾移植术后行主动脉瓣置换术一例

    Release date: Export PDF Favorites Scan
2 pages Previous 1 2 Next

Format

Content