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find Author "纪淑兴" 5 results
  • EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR GENE IN THE HYPERTROPHIC SCAR AND KELOID TISSUE

    Objective To explore the effect of connective tissue growth factor on the pathogenesis of hypertrophic scar and keloid tissue. Methods The content of hydroxyproline was determined and the expression of connective tissue growth factor gene was detected by the reverse transcription-polymerase chain reaction and image analysis technique in 5 normal skins, 15 hypertrophic scars and 7 keloid tissues. Results The contents of hydroxyproline in the hypertrophic scar(84.10±1.76) and keloid tissue (92.38±2.04) were significantly higher than that of normal skin tissue (26.52 ± 4.10) (P lt; 0.01). The index of connective tissue growth factor mRNA in the hypertrophic scar (0.78 ± 0.63) and keloid tissue (0.84 ± 0.04) were higher than that of normal skin tissue ( 0.09 ± 0.25) (P lt; 0.01). Conclusion Connective tissue growth factor may play an important role in promoting the fibrotic process of hypertrophic scar and keloid tissue.

    Release date:2016-09-01 09:35 Export PDF Favorites Scan
  • Expression of Nogo receptor in rats′ retina during the postnatal development

    Objective To observe the expression of Nogo66 receptor (NgR)in ratsprime; retina during the postnatal development. Methods The expression of NgR in 48 rats were observed by immunofluorescence histochemistry and laserconfocal microscopy 0, 3, 7, 14, 21, 35, 49, 63 days after birth, with 6 rats in each group, respectively. Results The expression of NgR is positive in the retina in the whole duration of growth, and the fluorescence pigmentation was located around the ganglion cell nuclaear. Conclusion The positive expression of NgR suggests that the interaction of NgR and CNS myelin inhibitors not only inhibit neuronal plasticity but also promote it, which could regulate neuronal plasticity.

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 黄斑裂孔手术治疗中内界膜的处理

    黄斑裂孔手术中内界膜(internal limiting membrane,ILM)剥除的有效性尚有许多争议。目前,多数研究者提倡进行ILM的剥除。因ILM的剥除提高了黄斑裂孔手术的解剖成功率,并使视力明显提高,且缩短了手术后俯卧位的时间;但在手术适应证的选择上还存在分歧。文献报道的资料由于标准不同,难以进行统计学方面比较。只有前瞻、随机、双盲、足够病例的临床试验,进一步加强临床追踪以及随着黄斑裂孔手术方式、技巧的不断改进完善,进一步验证ILM剥除的利弊,才能对其做出全面客观的评价。 (中华眼底病杂志,2003,19:201-268)

    Release date:2016-09-02 06:00 Export PDF Favorites Scan
  • Optical coherence tomography features of central exudative chorioretinopathy

    Objective lt;brgt;To investigate the morphological features of choroidal neovascularization (CNV) in central exudative chorioretinopathy (CEC) using optical coherence tomography(OCT). lt;brgt; lt;brgt;Methods lt;brgt;OCT and fundus fluorescein angiography (FFA) were performed in 41 cases (43 eyes) of CEC,and the course of CEC disease was from 1 week to 10 months. Twenty-seven of 43 eyes were also examined by indocyanine green angiography (ICGA). lt;brgt; lt;brgt;Results lt;brgt;OCT images revealed 5 kinds of morphological features of CEC: well-defined CNV(41.86 %),poorly-defined CNV(30.23 %),hemorrhagic pigment epithelium detachment (PED)(16.28 %), CNV companied with serous (6.98 %) or hemorrhagic neurosensory retina detachment (4.65 %). CNV mainly showed well-defined and poorly-defined CNV (72.09 %).In those eyes that could clear define the CNV boundary,there were 12 eyes on FFA examination and 20 eyes on ICGA examination which defined the boundary from retinal horizontal plane, while there were 23 eyes on OCT examination which defined the boundary from retinal vertical section. Classic CNV on FFA consistently presented with well-defined boundaries on OCT, whereas non-classic CNV had a variable cross-sectional appearance. lt;brgt; lt;brgt;Conclusions lt;brgt;The OCT morphological features of CNV in CEC is mainly well-defined CNV and poorly-defined CNV; OCT examination can precisely observe the retinal and choriocapillaries pathological anatomy of CEC from retinal vertical section, in making the CEC diagnosis as an important complementary examination of FFA and ICGA which observe the focus from retinal horizontal plane. lt;brgt; lt;brgt;(Chin J Ocul Fundus Dis, 2002, 18: 121-124)

    Release date:2016-09-02 06:01 Export PDF Favorites Scan
  • Usher综合征一例

    Release date:2016-09-02 06:01 Export PDF Favorites Scan
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