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find Keyword "纯红细胞再生障碍" 3 results
  • 系统性红斑狼疮继发纯红细胞再生障碍一例

    【摘要】 目的 提高对系统性红斑狼疮继发纯红细胞再生障碍(pure red cell aplasia,PRCA)的诊断和治疗认识。 方法 报道系统性红斑狼疮继发PRCA病例1例,观察患者对甲泼尼龙联合环孢素治疗的疗效。 结果 使用甲泼尼龙联合环孢素治疗后,系统性红斑狼疮继发PRCA患者血红蛋白恢复良好。 结论 大多数系统性红斑狼疮继发PRCA患者对糖皮质激素和免疫抑制剂联合治疗反应良好。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 异基因造血干细胞移植后继发性纯红细胞再生障碍性贫血患者的护理

    【摘要】 目的 总结异基因造血干细胞移植(allo-PBSCT)后发生继发性纯红细胞再生障碍性贫血(PRCA)的护理,以提高对此类患者的护理。 方法 对2007年1月-2008年12月收治的2例allo-PBSCT后发生PRCA患者的护理进行回顾性总结。 结果 allo-PBSCT后发生PRCA较少见,但在此过程中存在的严重贫血可能会危及患者生命。 结论 allo-PBSCT后发生PRCA的护理关键是针对贫血的各项护理措施。

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • Clinical characteristics and treatment of six kidney recipients with human parvovirus B19 infection

    ObjectiveTo investigate the diagnosis, clinical features, treatment and outcome of pure red cell aplasia (PRCA) caused by human parvovirus B19 (HPV-B19) infection in kidney recipients. Method The clinical courses of six patients with PRCA caused by HPV-B19 infection after renal transplantation in West China Hospital between May 2018 and April 2019 were retrospectively investigated. Results The six patients showed obvious anemia symptoms, lacking rash, joint pain and other clinical symptoms of viral infection. The hemoglobin level of five patients got totally remission from a course of intravenous immunoglobulin (IVIG) treatment, and anemia symptoms like fatigue, weakness got notable improvement. One patient had no improvement after two courses of IVIG treatment, and his anemia was significantly improved after the third IVIG course combined with immunosuppressant conversion(from tacrolimus to cyclosporine), and one patient with recurrence accepted a repeated course of IVIG treatment and obtained remission of severe anemia again. The median time of reticulocyte firstly rose to above 0.084×1012/L from the day of IVIG treatment ended was 3.50 (1.25, 5.00) days, and the median time required for a 30 g/L increase in hemoglobin to the end of IVIG treatment was 16.00 (9.25, 31.25) days. No serious adverse reactions occurred and all patients had stable graft function. Conclusions The main clinical manifestations of PRCA caused by HPV-B19 infection after kidney transplantation are anemia symptoms, lacking other clinical symptoms of viral infection. HPV-B19 DNA detection combined with blood routine examination, reticulocyte count and bone marrow cytology (or none) can diagnose HPV-B19 infection. High dose of IVIG is effective and safe, and a repeated course is still effective when the infection recurs. For refractory PRCA that IVIG monotherapy fail, a combination with conversion from tacrolimus to cyclosporine can effectively improve the anemia without graft dysfunction.

    Release date:2019-08-15 01:18 Export PDF Favorites Scan
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