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find Keyword "细胞免疫治疗" 2 results
  • TSA-DC-CTL 细胞免疫治疗联合 PD-L1 抗体治疗高龄晚期结肠癌 1 例报道并文献复习

    目的报道 1 例肿瘤特异性抗原(TSA)刺激诱导树突状细胞(DC)及细胞毒性 T 淋巴细胞(CTL)过继治疗联合程序性死亡配体 1(PD-L1)抗体治疗高龄晚期结肠癌患者。方法2018 年 2 月笔者所在医院对 1 例 90 岁高龄女性患者因“回盲部癌伴梗阻”行剖腹探查、回盲部切除、小肠部分切除、末端回肠造瘘、腹膜活检术,肿瘤广泛转移,患者基础条件差,术后无法耐受常规治疗。经与患者家属充分沟通知情同意及解放军总医院伦理委员会批准,于术后 4 个月开始行 4 次 TSA-DC 细胞皮内多点注射,4 次 TSA-CTL 细胞静脉滴注,2 次 TSA-CTL 细胞腹腔注入,1 次 PD-L1 抗体 1 200 mg 静脉滴注。结果行 TSA-DC-CTL 联合 PD-L1 治疗后 7 d(治疗中期),患者的 KPS 评分升至 80 分(治疗前 40 分),外周血循环肿瘤细胞计数降至 7 个/3.2 mL(治疗前 16 个/3.2 mL),肿瘤标志物 CA125 降至 155.5 u/mL(治疗前 224.4 u/mL),治疗过程中未见相关不良反应。行 TSA-DC-CTL 联合 PD-L1 治疗后 36 d 患者突然出现血压和血氧饱和度下降,给与升压、兴奋呼吸等治疗,情况好转,因家属要求患者自动出院。结论TSA-DC-CTL 细胞免疫治疗联合 PD-L1 治疗本例高龄患者安全可行,能在一定程度上改善患者生活质量及部分生物学指标,但 TSA-DC-CTL 联合 PD-L1 抗体的安全性及近远期疗效有待进一步研究论证。

    Release date:2019-06-05 04:24 Export PDF Favorites Scan
  • Advances in immunotherapy for advanced gastric cancer

    ObjectiveTo recognize the latest research progress of immunotherapy for advanced gastric cancer (AGC). MethodThe domestic and international literature on immunotherapy for AGC in recent years were retrieved and reviewed. ResultsThe immunotherapy for AGC mainly focused on immune checkpoint inhibitors (ICIs), cellular immunity, and antitumor vaccines. The most immunotherapy researched was ICIs, especially for programmed death protein-1 / programmed death protein ligand 1, cytotoxic T lymphocyte associated antigen 4, and lymphocyte activating gene 3. The cellular immunotherapy and tumor vaccine therapy were less relatively. Although immunotherapy alone did not have a particularly good effect, its therapeutic effect was not inferior to that of chemotherapy alone and the incidence of adverse reactions was lower. Moreover, most studies had concluded that the use of immunotherapy in combination with other therapy had shown a good clinical efficacy, especially in combination with anti-human epidermal growth factor receptor 2 antibody, and chimeric antigen receptor T cells targeting Claudin 18.2 site had promising results in the AGC. ConclusionsWith the development of immunotherapy research, the strategies of immunotherapy for AGC are also constantly improving. Precision medicine is important in the process of immunotherapy. Targeted screening suitable patients and adopting precise treatment can further benefit the survival of patients with AGC.

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