软结肠镜的临床应用在肠道疾病的诊断及治疗上是一大进步，不但能诊断大肠及末端回肠疾病，更重要的是可以用来治疗一些经保守治疗无效的下消化道内科疾病以及一些外科疾病，如肠息肉、肠扭转等需外科手术才能治愈的疾病可用软结肠镜治疗。我们对1987年7月至2001年8月采用软结肠镜诊治的低位肠梗阻、乙状结肠扭转、假性结肠梗阻、下消化道出血、良性肠狭窄及肠道息肉等9 051例需外科处理的疾病加以探讨，以提高软结肠镜在治疗外科疾病中的安全性及疗效。
The results of 2389 patients exmained by colonofiverscope in past nine years are reported. Polyps were found in 561 cases, including 1256 polyps in the large intestine and 82 polyps in the terminal ileum. All 1299 polyps were removed with biopsy forceps. Pathology demonstrated that there were 406 adenomas, including 89 atypical hyperplasia and 23 cases with malignant change and 932 non-canerous polyps with 102 atypical hyperplasia. Since adenoma is seen to be a precancerous change, the polypectomy by colonofiberscope , ecpecially atypical hyperplastic polyps may decrease morbidity of large intestinal cancer. Cancer associated with adenoma may be as high as 51.28%, so the recrudescence of polyps may possibly be found even afer the cancer removal. These data showed that an early discovery of small malignant adenoma is key to improve efficiency.
Objective To evaluate the effect of visual and audiovisual distraction on anxiety and acceptance levels among patients undergoing colonoscopy. Methods A total of 180 consecutive patients undergoing colonoscopy were randomly divided into three groups: group A received visual distraction; group B received audiovisual distraction; and group C received routine care alone. Levels of anxiety and willingness to accept the same intervention if the procedure needed to be repeated were compared among the three groups. Results The reduction of anxiety score after colonoscopy in group A and group B was greater than that in group C, but the difference was not statistically significant. The rate of willingness to accept the same intervention if the procedure needed to be repeated was significantly different among the three groups: the rates for group A and group B were higher than for group C (Plt;0.05). Conclusions Both visual distraction and audiovisual distraction can significantly improve patients’ acceptance of colonoscopy. Visual distraction and audiovisual distraction have no significant effect on reducing anxiety.
Objective To evaluate the difference of oral sodium phosphate (NaP) and polyethylene glycol-electrolyte lavage solution (PEG-ELS) in the aspects of cleansing efficacy, tolerance, and safety in clinical practice, so as to provide evidence for clinical practice. Methods A systematic review of all the relevant randomized controlled trials (RCTs) was performed according the handbook of the Cochrane Collaboration. RCTs were identified from The Cochrane Library(Issue1,2004) MEDLINE(1980-2004), EMBASE(1984-2004),and CBM(1978-2004).Handsearching was also performed .RCTs comparing the two methods were selected .Tow reviewers independently assessed the quality of included trials and extracted data independently .Results Eighteen trials involving 3668 patients were included .Sub-group analysis was performed. Nap tablet had higher rate of adequate cleansing quality (RR1.08,95%CI1.02 to 1.05,p=0.01).Two-day ,divided-dose oral Nap was superior in the rate of adequate cleansing quality (RR1.27,95%CI1.06 to 1.52,p=0.009). .The. rate of adequate cleansing quality in right colon of Nap was lower than PEG-ELS(RR0.79,95%CI 0.64 to 0.98,p=0.03).The rate of abdominal cramps (RR 0.84,95%CI 0.72 to 0.99),the rate of abdominal fullness (RR 0.48,95%CI 0.26 to 0.89),the rate of nausea (RR 0.65,95%CI 0.56 to 0.76)and the percentage of patients who didn’t finished their prescribed regimen (RR 0.23,95%CI0.14 to 0.36)in Nap group were lower (plt;0.05).Conclusions Compared with PEG-ELS,Nap is superior in cleansing efficacy , patients’ tolerance ,safety and economy . It is possible to promote the use of Nap in clinical practice in China .
目的:观察舒芬太尼复合异丙酚自控镇静镇痛在结肠镜检查中的效果及不良反应,从而探讨该方法的安全性和有效性。方法:行无痛纤维结肠镜检查的患者60例,随机分为两组:自控镇痛/镇静组和静脉复合全麻醉组,每组30例。自控镇痛/镇静组首先缓慢静脉注射舒芬太尼0.12 μg/kg,随之接电子自控镇痛泵,负荷量设定为0.5 mg/kg,以4 mg/kg·h的速度持续泵入异丙酚(10 mg/mL),术中按压1次自控手柄可快速推注异丙酚1 mL。静脉复合全麻醉组首先静脉缓慢推注芬太尼1 μg/kg,咪唑安定0.02 mg/kg, 2 min后缓慢推注异丙酚0.8～1 mg/kg。术中间断给予异丙酚以维持听觉诱发电位指数(AAI)于30～40之间。结果:静脉复合全麻醉组的MAP较检查前明显下降且较自控镇痛/镇静组下降更为明显且具有统计学意义(Plt;0.05)。自控镇痛/镇静组的呼吸频率较静脉复合全麻醉组下降明显且在T3时间点具有统计学意义(Plt;0.05)。自控镇痛/镇静组患者OAA/S评分达5分和Aldrete评分达9分的时间均较静脉复合全麻醉组明显缩短(1.4±1.3 VS 3.9±1.7和 2.9±1.7 VS 5.7±1.7)(Plt;0.05)。两组的内镜医师和患者满意度评分无统计学差异(P＞0.05)。结论:自控镇静镇痛能够比传统的静脉全身麻醉提供更良好的循环系统稳定性,更迅速的麻醉后恢复,是结肠镜检查镇静镇痛的理想和安全方法。
目的 探讨腹腔镜术中联合结肠镜治疗结直肠小占位病变的可行性和临床应用价值。方法对我院2006年12月至2009年5月期间23例行腹腔镜联合结肠镜手术的结直肠小占位病变患者的临床资料进行回顾性分析。结果 所有患者均在腹腔镜下完成手术，无中转开腹。 手术时间80～200 min，平均140 min; 出血80~120 ml，平均100 ml。 9例息肉病变行局灶切除，术中经快速冰冻切片病理证实4例早期癌及10例不典型增生均行相应肠段切除。 术后1例出现轻度肺炎，经积极抗炎对症治疗后痊愈，其余患者恢复良好。 所有患者术后第1天即离床活动，住院时间5～10 d，平均7 d。结论 腹腔镜术中联合结肠镜治疗结直肠占位是安全可行的，有助于结直肠病灶及切缘的准确定位，可缩短手术时间，值得临床进一步推广应用。
Colonoscopy examination is the gold standard for diagnosis and treatment of colon diseases and screening for early cancer. Good quality of bowel preparation, which is also called intestinal cleanliness, is the prerequisite for full visualization of colonic mucosal lesions and their details. In clinic, more intestinal cleansing agents, such as polyethylene glycol and magneium suifate, have bad taste and high dosage, which can not be tolerated by some patients and affect the effect of bowel preparation. The use of oral adjuvant, add adjuvant to intestinal cleansing agents, new low-volume or very low-volume polyethylene glycol-ascorbic acid preparation methods, can reduce the incidence of adverse reactions, such as nausea and vomiting in patients, improve their tolerance, satisfaction and so on. This article reviews the methods of improving the taste and reducing the adverse reactions of intestinal cleansing agents at home and abroad to offer references for clinical practice.
ObjectiveTo systematically evaluate the efficacy and safety of computer-aided detection (CADe) and conventional colonoscopy in identifying colorectal adenomas and polyps. MethodsThe PubMed, Embase, Cochrane Library, Web of Science, WanFang Data, VIP, and CNKI databases were electronically searched to collect randomized controlled trials (RCTs) comparing the effectiveness and safety of CADe assisted colonoscopy and conventional colonoscopy in detecting colorectal tumors from 2014 to April 2023. Two reviewers independently screened the literature, extracted data, and evaluated the risk of bias of the included literature. Meta-analysis was performed by RevMan 5.3 software. ResultsA total of 9 RCTs were included, with a total of 6 393 patients. Compared with conventional colonoscopy, the CADe system significantly improved the adenoma detection rate (ADR) (RR=1.22, 95%CI 1.10 to 1.35, P<0.01) and polyp detection rate (PDR) (RR=1.19, 95%CI 1.04 to 1.36, P=0.01). It also reduced the missed diagnosis rate (AMR) of adenomas (RR=0.48, 95%CI 0.34 to 0.67, P<0.01) and the missed diagnosis rate (PMR) of polyps (RR=0.39, 95%CI 0.25 to 0.59, P<0.01). The PDR of proximal polyps significantly increased, while the PDR of ≤5 mm polyps slightly increased, but the PDR of >10mm and pedunculated polyps significantly decreased. The AMR of the cecum, transverse colon, descending colon, and sigmoid colon was significantly reduced. There was no statistically significant difference in the withdrawal time between the two groups. Conclusion The CADe system can increase the detection rate of adenomas and polyps, and reduce the missed diagnosis rate. The detection rate of polyps is related to their location, size, and shape, while the missed diagnosis rate of adenomas is related to their location.