【摘要】 目的 观察综合疗法治疗大龄儿童弱视的疗效。 方法 回顾分析2008年1月-2010年10月在我院初诊并经综合治疗的8～13岁弱视儿童62例85只眼的临床资料。治疗前最佳矫正视力0.1~0.7，平均0.46±0.17。观察患者经弱视综合治疗后视力、空间对比敏感度及立体视提升效果。 结果 治疗后视力正常22例31只眼（36.5%），进步29例39只眼（45.9%），无效11例15只眼（17.6%）；总有效率82.4%，与治疗前相比，差异有统计学意义（Plt;0.001）。空间对比敏感度基本正常11例16只眼（18.8%），进步43例58只眼（68.2%），无效8例11只眼（12.9%）。弱视眼在1.5、3、6三个低空间频率的对比敏感度值与治疗前相比提升有统计学意义（Plt;0.001）；在12和18两个高空间频率，对比敏感度值与治疗前相比提升无统计学意义（Pgt;0.05）。立体视锐度正常12例（19.4%），进步26例（41.9%），无效24例（38.7%），立体视锐度与治疗前相比提升具有统计学意义（Plt;0.001）。 结论 综合疗法治疗大龄儿童弱视能取得令人较为满意的疗效，患儿视力显著提升，低到中等频率空间对比敏感度及立体视锐度也有较大提升。【Abstract】 Objective To explore the therapeutic effect of comprehensive therapy on elder children with amblyopia. Methods The clinical data of 62 patients (85 eyes) with amblyopia who underwent the comprehensive therapy between January 2008 and October 2010 were retrospectively analyzed. The best-corrected visual acuity was 0.1-0.7 (mean 0.46±0.17) before the treatment. The visual acuity, spatial contrast sensitivity and stereoacuity of the patients after the treatment were observed. Results After the comprehensive therapy, the visual acuity was normal in 22 patients (31 eyes, 36.5%), improved in 29 patients (39 eyes, 45.9%), invalid in 11 patients (15 eyes, 17.6%). The total effective rate was 82.4% which was differed significantly from that before the treatment (Plt;0.001). The spatial contrast sensitivity was almost normal in 11 patients (16 eyes, 18.8%), improved in 43 patients (58 eyes, 68.2%), and invalid in 8 patients (11 eyes, 12.9%). The examination of spatial contrast sensitivity showed that the improvement was only statistically significant when frequency equates 1.5, 3, or 6 (Plt;0.001) compared with those before the treatment; while no statistically significant improvement was observed in higher frequencies of 12, 18 (Pgt;0.05). The stereoacuity was normal in 12 patients (19.4%), improved in 26 (41.9%), and invalid in 24 (38.7%); the difference in stereoacuity before and after the treatment was significant (Plt;0.001). Conclusion The therapeutic effect of comprehensive therapy is good: the visual acuity of the patients improves obviously, and the low to middle spatial contrast sensitivity and stereoacuity improve apparently.