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find Keyword "缩宫素" 3 results
  • 地诺前列酮用于妊娠足月羊水过少引产的临床研究

    目的探讨地诺前列酮用于妊娠足月羊水过少产妇引产的有效性和安全性。 方法选择2009年3月-2014年3月140例足月妊娠羊水过少产妇,按引产方式不同分为地诺前列酮组(n=76)和缩宫素组(n=64),比较两组的宫颈评分改变、临产和分娩情况、新生儿情况以及不良反应。 结果地诺前列酮组与缩宫素组促宫颈成熟有效率分别为92.1%、62.4%,进入产程时间分别为(9.2±5.7)、(30.8±9.1)h,产程分别为(5.2±2.6)、(10.8±3.9)h,阴道分娩率分别为87.0%、56.1%,剖宫产率分别为13.0%、43.9%,住院时间分别为(3.5±1.3)、(6.3±1.5)d,以上指标组间差异均有统计学意义(P<0.001);两组产后2 h出血量分别是(216±129)、(223±148)mL,新生儿窒息发生率分别是3.9%、3.1%,差异无统计学意义(P>0.05)。 结论羊水过少并非阴道分娩禁忌证,地诺前列酮用于足月妊娠羊水过少产妇引产较为安全有效,能显著提高阴道分娩率,降低剖宫产率。

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  • Effect of Motherwort Injection in Promoting Postpartum Involution of Uterus: A Meta-analysis

    ObjectiveTo systematically evaluate the effect of combination of motherwort injection and oxytocin for promoting the involution of uterus. MethodsData of randomized controlled trials (RCTs) of motherwort injection and oxytocin in promoting the effect of postpartum involution of uterus were collected by searching the electronic databases including PubMed, EMbase, CNKI, WanFang Data, CENTRAL and WHO ICTRP from inception to August 26th, 2016. Two reviewers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. Meta-analysis was conducted by RevMan 5.3 software. ResultsA total of 18 RCTs involving 6 468 patients were included. The results of meta-analysis showed that:Compared with the oxytocin alone group, the combination group of motherwort injection and oxytocin was higher on promoting the drop height of uterus (MD=1.33, 95%CI 1.03 to 1.63), lower on the height of uterus (MD=-2.12, 95%CI -2.64 to -1.61) and duration of lochia (MD=-7.11, 95%CI -8.84 to -5.38). There was no statistical difference in adverse effect rate between the two groups (OR=0.87, 95%CI 0.64 to 1.19, P=0.38). ConclusionsMotherwort injection combined with oxytocin is superior to oxytocin alone in promoting the drop height of postpartum uterus and shortening the duration of lochia. Because of the low quality of the included studies, more high quality RCTs are needed to prove the above conclusion.

    Release date:2016-11-22 01:14 Export PDF Favorites Scan
  • The efficacy and safety of carbetocinversusoxytocin on the prevention of postpartum hemorrhage for women undergoing vaginal delivery: a meta-analysis

    Objectives To systematically review the efficacy and safety of carbetocinversusoxytocin on the prevention of postpartum hemorrhage (PPH) for women undergoing vaginal delivery. Methods PubMed, The Cochrane Library, Web of Science, CBM, WanFang Data, CNKI and VIP databases were electronically searched to collect randomized controlled trials (RCTs) on carbetocinversusoxytocin on the prevention of PPH for women undergoing vaginal delivery from inception to January 2018. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 and Stata 12.0 software. Results A total of 16 RCTs including 2 537 patients were included. The results of meta-analysis showed that: compared to oxytocin, carbetocin could reduce the amount of blood loss within 24h (MD=–107.68, 95%CI–130.21 to –85.15, P<0.000 01) and 2h (MD=–85.98, 95%CI–93.37 to –78.59,P<0.000 01), hemoglobin (Hb) within 24h after delivery (MD=–5.63, 95%CI–6.82 to –4.43,P<0.000 01), the occurrence of PPH (RR=0.46, 95%CI 0.32 to 0.66,P<0.000 01) and the requirement for additional uterotonic agents (RR=0.63, 95%CI 0.48 to 0.84,P=0.002). There was no significant difference in the risk of adverse effects between two groups. Conclusions Current evidence shows that carbetocin is superior to oxytocin in the prevention of PPH for women undergoing vaginal delivery, without increasing the adverse effects. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above the conclusion.

    Release date:2018-10-19 01:55 Export PDF Favorites Scan
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