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find Author "罗程" 4 results
  • 特发性全面性癫痫的神经影像研究进展

    特发性全面发作性癫痫(Idiopathic generalized epilepsy, IGE)是一类没有明显病因和大脑病灶的癫痫, 主要脑电图(EEG)表现为突出背景的双侧对称的癫痫放电。现在新兴的无创的神经成像技术改变了以前对IGE的脑结构和功能网络的研究模式。当前的研究者已经迅速地采用这些新技术研究IGE的脑特征性改变, 包括EEG、功能磁共振、同步脑电和功能磁共振、结构磁共振、弥散张量成像以及结构功能脑网络技术。这些发现表明IGE中皮层-丘脑网络中存在着结构和功能指标的异常, 且越来越多的多模态神经成像结果也评估了癫痫活动对大量脑功能网络的影响。将来的研究将集中在多学科的融合和发展多模态神经成像技术, 更深入地研究IGE的脑网络机制

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  • MRI 阴性药物难治性颞叶癫痫合并抑郁症患者的静息态功能磁共振研究

    Release date:2018-05-22 02:14 Export PDF Favorites Scan
  • Degree centrality of the functional network in schizophrenia patients

    The aim of the present study was to investigate the alternations of brain functional networks at resting state in the schizophrenia (SCH) patients using voxel-wise degree centrality (DC) method. The resting-state functional magnetic resonance imaging (rfMRI) data were collected from 41 SCH patients and 41 matched healthy control subjects and then analyzed by voxel-wise DC method. The DC maps between the patient group and the control group were compared using by two sample t test. The correlation analysis was also performed between DC values and clinical symptom and illness duration in SCH group. Results showed that compared with the control group, SCH patients exhibited significantly decreased DC value in primary sensorimotor network, and increased DC value in executive control network. In addition, DC value of the regions with obvious differences between the two groups significantly correlated to Positive and Negative Syndrome Scale (PANSS) scores and illness duration of SCH patients. The study showed the abnormal functional integration in primary sensorimotor network and executive control network in SCH patients.

    Release date:2017-12-21 05:21 Export PDF Favorites Scan
  • Altered Perceptual Networks in Tuberous Sclerosis Complex Patients with Epilepsy Revealed by Resting Functional Magnetic Resonance Imaging

    ObjectiveTo reveal impairments in the perceptual networks in tuberous sclerosis complex (TSC) with epilepsy by functional connectivity MRI (fcMRI). MethodsThe fcMRI-based independent component analysis (ICA) was used to measure the resting state functional connectivity in nine TSC patients with epilepsy recruited from June 2010 to June 2012 and perceptual networks including the sensorimotor network (SMN), visual network (VN), and auditory network (AN) were investigated. The correlation between Z values in regions of interest (ROIs) and age of seizure onset or duration of epilepsy were analyzed. ResultsCompared with the controls, the TSC patients with epilepsy presented decreased functional connectivity in primary visual cortex within the VN networks and there were no increased connectivity. Increased connectivity in left middle temporal gyrus and inferior temporal gyrus was found and decreased connectivity was detected in right inferior frontal gyrus within AN networks. Decreased connectivity was detected at the right inferior frontal gyrus and the increase in connectivity was found in right thalamus within SMN netwoks. No significant correlations were found between Z values in ROIs including the primary visual cortex within the VN, right thalamus and inferior frontal gyrus within SMN, left temporal lobe and right inferior frontal gyrus within AN and the duration of the disease or the age of onset. ConclusionFhere is altered (both increased and decreased) functional connectivity in the perceptual networks of TSC patients with epilepsy. The decreased functional connectivity may reflect the dysfunction of correlative perceptual networks in TSC patients, and the increased functional connectivity may indicate the compensatory mechanism or reorganization of cortical networks. Our fcMRI study may contribute to the understanding of neuropathophysiological mechanisms underlying perceptual impairments in TSC patients with epilepsy.

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