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find Author "肖荣冬" 4 results
  • 低温生理盐水与腺苷局部灌注对脊髓缺血损伤的保护作用

    目的 研究低温生理盐水和腺苷对兔主动脉阻断致脊髓缺血损伤的保护作用。 方法 30只成年健康新西兰白兔随机分成3组,每组10只。A组:作为缺血对照;B组:用低温生理盐水局部灌注;C组:用低温生理盐水和腺苷局部灌注。通过阻断兔肾动脉水平的腹主动脉60分钟建立兔脊髓缺血损伤模型。观察3组血流动力学指标、脊髓自由基含量、术后Tarlov评分和脊髓组织病理学改变。 结果 3组心率比较均无差异,C组血压于阻断腹主动脉20分钟时下降(P<0.05);A组丙二醛增加,超氧化物歧化酶减少,而B组和C组变化较轻;A组大部分发生截瘫,B组后肢功能部分恢复,C组后肢功能恢复良好;病理检查示A组中央灰质聚集性坏死,巨噬细胞浸润,尼氏小体消失,核仁模糊,B组和C组脊髓结构较完整。 结论 低温生理盐水和腺苷局部灌注具有良好的脊髓保护作用,其方法简便。腺苷可减少三磷酸腺苷(ATP)的耗竭,促进其恢复,并具有神经保护作用。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • 感染性心内膜炎的围术期治疗和危险因素分析

    目的总结感染性心内膜炎的外科治疗经验,对其围术期危险因素进行分析。 方法回顾性分析2006年1月至2012年12月福建省立医院224例感染性心内膜炎患者行外科手术治疗的临床资料,男127例,女97例;年龄1~72(47.7±7.2)岁。均有心脏基础性病变,包括心脏瓣膜病171例(二尖瓣病变99例,主动脉瓣病变30例,双瓣膜病变42例);先天性心脏病40例(先天性二尖瓣关闭不全14例,主动脉瓣关闭不全5例,动脉导管未闭2例,室间隔缺损10例,法洛氏三联症1例,室间隔缺损合并瓦氏窦瘤脱垂3例,室间隔缺损术后主动脉窦脱垂伴主动脉瓣关闭不全4例,先天性主动脉瓣畸形合并动脉导管未闭1例);3例梅毒性二尖瓣主动脉瓣病变;8例亚急性细菌性心内膜炎(SBE)行主动脉瓣置换术后瓣周漏再发SBE;2例主动脉瓣病变合并动脉导管未闭。分析术后并发症及死亡率,探讨SBE患者的高危因素及治疗方法。 结果术中探查赘生物192例,全部送培养,阳性100例,检出率52.08%,其中以金黄色葡萄球菌、表皮葡萄球菌、草绿色链球菌为多见。手术近期死亡10例,死亡率4.46%,主要并发症有低心排血量综合征、肾功能衰竭、术后严重感染、出血、肝功能损害等。 结论感染性心内膜炎内科难以控制者应尽早手术治疗。术前心功能低下、严重的耐药性金黄色葡萄球菌感染、心瓣膜置换术后再发感染及术前营养状况不良是感染性心内膜炎治疗的高危因素。

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  • Video-assisted thoracic surgical technique versus conventional surgical technique for mitral valve replacement: A case control study

    Objective To compare video-assisted thoracic surgical technique (VATS) and conventional surgical technique (CSM) in mitral valve replacement (MVR). Methods We retrospectively analyzed clinical data of 93 patients in our hospital with mitral valve replacement between January 2010 and January 2015. The patients were divided into two groups including a VATS group and a CSM group.There were 43 patients with 25 males and 18 females at age of 57.43±5.65 years in the VATS group, and 50 patients with 27 males and 23 females at age of 56.40±6.32 years in the CSM group.The clinical outcomes of the two groups were compared. Results There was no mortality. Echocardiography was normal in both groups during 1-year follow-up. There was no significant difference between the two groups in the operative time, aortic clamping time, cardiopulmonary bypass (CPB) time, or ventilation time. As compared with the CSM group, the patients in the VATS group had a significantly lower complication rate, shorter chest incision length (5.23±1.36 cm vs. 18.21±3.89 cm), less blood transfusion (1.75±0.25 U vs. 3.15±1.50 U), less chest drainage (202.34±12.12 ml vs. 412.32±21.56 ml) and lower pain score (1.26±0.86 vs. 3.01±1.13), shorter time of postoperative hospital stay (8.20±2.36 d vs. 12.10±3.26 d). Conclusion MVR under VATS is not only technically feasible, but also with excellent clinical results.

    Release date:2017-09-04 11:20 Export PDF Favorites Scan
  • Mitral Valvuloplasty with Artificial Chord and Mitral Annuloplasty Ring for the Treatment of Mitral Valve Prolapse

    ObjectiveTo evaluate outcomes of mitral valvuloplasty with artificial chord and mitral annuloplasty ring in patients with mitral valve prolapse. MethodsFrom January 2012 to March 2014, mitral valvuloplasty with artificial chord and mitral annuloplasty ring were performed for 58 patients with mitral valve prolapsed in Department of Cardiovascular Surgery, Fujian Provincial Hospital, among which 47 simple anterior or posterior mitral valvuloplasty and 11 combined anterior-posterior mitral valvuloplasty were completed. There were 33 males and 25 females aged (53.7±14.3) years. ResultsThere was no in-hospital death. Three patients received mitral valve replacement. The transoesophageal echocardiography found no or trivial mitral regurgitation in 48 patients, mild mitral regurgitation in 7 patients. The diameter of the left atrium (LA) and left ventricle (LV), left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) were significantly decreased after the operation. During the follow-up of 6 months to 2 years, the cardiac function of the patients improved. ConclusionMitral valvuloplasty with artificial chord and mitral annuloplasty ring is simple, reliable and effective treatment for patients with mitral valve prolapse, and its shortand mid-term outcome is good.

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