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find Author "胡超华" 5 results
  • Fas/FasL在肝癌细胞中的表达与肝癌浸润转移关系相关性研究

    目的通过检测有浸润转移和无浸润转移肝细胞癌中Fas及Fas-L蛋白的表达,探讨它们在肝细胞癌发生发展中的作用。 方法采用免疫组织化学方法检测20例有浸润转移和40例无浸润转移肝细胞癌组织及10例肝良性肿瘤(肝血管瘤、肝囊肿)组织中Fas及Fas-L蛋白的表达,分析其与肝细胞癌浸润转移的关系。 结果60例肝细胞癌组织中Fas及Fas-L蛋白的表达阳性率分别为70.00%(42/60)和68.33%(41/60),10例肝良性肿瘤组织中Fas及Fas-L蛋白的表达阳性率均为30.00%(3/10);20例有浸润转移的肝细胞癌组织中,Fas和Fas-L蛋白表达阳性率均为95.00%(19/20)。Fas和Fas-L蛋白在肝细胞癌组织中的表达阳性率高于肝良性肿瘤组织,在有浸润转移的肝细胞癌组织中的表达阳性率高于无浸润转移者,差异均有统计学意义(P<0.05)。 结论肝细胞癌组织中Fas和Fas-L蛋白的表达很有可能作为判断肿瘤浸润转移能力的指标。

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  • Explore the sweeping strategy of cervical lymph node metastasis in papillary thyroid carcinoma once again

    ObjectiveTo investigate the influencing factors of cervical lymph node metastasis of papillary thyroid carcinoma (PTC) and provide more accurate guidance for the cleaning strategy of PTC cervical lymph node.MethodsRetrospectively analyzed the case data of pathological diagnosis of PTC patients from June 2013 to June 2019 in Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, and explored the influencing factors of lymph node metastasis in central region and lymph node metastasis in lateral cervical region.ResultsThe results of multivariate analysis showed that patients aged ≤55 years old, tumor diameter >1 cm, peripheral invasion, bilateral cancer, and multifocal cancer had a higher lymph node metastasis rate in the central region (P<0.05). When the number of risk factors mentioned above was 0, 1, 2, 3, 4, 5 and 6, the lymph node metastasis rate in the central region was respectively: 3.5% (4/113), 25.2% (72/286), 30.0% (70/233), 38.6% (76/197), 52.5% (53/101), 76.9% (20/26), and 100% (13/13). With the increase of the number of risk factors, the lymph node metastasis rate in central region increased (χ2=236.894, P<0.001). In the lymph node metastasis in lateral cervical region, multivariate analysis showed that patients with tumor diameter >1 cm, membranous invasion, and lymph node metastasis in the central region ≥2 had a higher lymph node metastasis rate (P<0.05), while lymph node metastasis in the lateral cervical region was not related to age, gender, peripheral invasion, and multifocal carcinoma (P>0.05). When the cumulative number of risk factors in patients was 0, 1, 2, 3, 4, 5, and 6, the lymph node metastasis rate in the lateral cervical region was respectively: 11.1% (1/9), 29.4% (5/17), 79.2% (19/24), 89.6% (43/48), 96.4% (27/28), 100% (21/21), and 100% (3/3). With the increase in the number of risk factors, lymph node metastasis in the lateral cervical region increased (χ2=101.094, P<0.001).ConclusionsThe cervical lymph node metastasis is positively correlated with the number of corresponding risk factors. With the increase of risk factors, cervical lymph node metastasis rate also increases. The number of risk factors provides a simple and intuitive indicator for cervical lymph node metastasis, which is more conducive to the formulation of individualized and accurate surgical program.

    Release date:2019-11-25 03:18 Export PDF Favorites Scan
  • Surgical Treatment of Hilar Cholangiocarcinoma

    目的 探讨肝门部胆管癌2种手术方法的疗效。方法 回顾性分析我院1998~2006年期间收治的37例肝门部胆管癌患者的临床资料。结果 37例患者中13例行根治性手术切除, 其1年与3年的生存率分别为100%(13/13)和76.92%(10/13),中位生存期为22.43个月; 另24例行姑息性手术(均为肝内胆管内引流术),其1年与3年生存率分别为54.55%(12/22)和9.09%(2/22),中位生存期为15.42个月。结论 根治性手术是治疗肝门部胆管癌的主要手段; 姑息性手术,如合理的肝内胆管内引流能改善患者的生存质量。

    Release date:2016-09-08 10:56 Export PDF Favorites Scan
  • Cinical Analysis of 63 Cases of Laparoscopic Splenectomy

    目的探讨腹腔镜脾切除术的安全性及疗效。 方法回顾分析2008年5月至2012年10月期间笔者所在医院完成的63例腹腔镜脾切除术患者的资料。其中特发性血小板减少性紫癜8例,自身免疫性溶血性贫血1例,脾囊实性占位性病变6例,肝硬变伴门静脉高压、脾功能亢进48例。 结果63例患者均顺利完成腹腔镜脾切除术,无中转开腹,手术时间80~250 min,平均136.5 min;术中出血100~2 100 mL,平均220 mL;住院时间6~14 d,平均7.4 d。术后无手术死亡。 结论腹腔镜脾切除术安全、有效、可行,手术成功的关键是防止术中大出血。

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  • Application of thyroidectomy by meticulous capsular dissection technique through neck incision approach in treatment of 75 patients with type Ⅰ substernal goiter

    Objective To assess clinical value of thyroidectomy by meticulous capsular dissection technique through neck incision approach in treatment of 75 patients with type Ⅰ substernal goiter. Methods The clinical data of 75 patients with type Ⅰ substernal goiter in the Department of General Surgery of the Central Hospital of Xiaogan from April 2013 to April 2017 were retrospectively analyzed. These patients received the surgical resection by the meticulous capsular dissection technique with an ultrasonic scalpel and a bipolar coagulation forcep through neck incision approach. Results There were 12 Hashimoto thyroiditis, 10 thyroid adenoma, 41 nodular goiter, and 12 thyroid carcinoma in the 75 patients with type Ⅰ substernal goiter. Five cases underwent the unilateral total thyroidectomy. Fifty-eight cases underwent the bilateral total thyroidectomy. The bilateral total thyroidectomy plus central lymph node dissection were performed in the 9 patients with thyroid carcinoma, the bilateral total thyroidectomy plus central lymph node dissection plus affected ipsilateral neck lymph node dissection were performed in the 3 patients with thyroid carcinoma. The average operative time was 100 min, the average intraoperative blood loss was 50 mL, the average postoperative hospital stay was 5 d. The rate of parathyroid injury was 2.7% (2/75), the rate of hypocalcemia caused by parathyroid injury was 2.7% (2/75). There were 3 cases (4.0%) of unilateral recurrent laryngeal nerve injury, 1 case (1.3%) of the outer branch of the upper laryngeal nerve injury. There were 2 cases of tracheal partial softening in the 75 patients. None of postoperative bleeding and seroma happened. No death and the tumor recurrence and metastasis of patients happened during follow-up period. Conclusions Preliminary results in this study show that operation of meticulous capsular dissection technique with an ultrasonic scalpel and a bipolar coagulation forcep through neck incision approach in treatment of type Ⅰ substernal goiter is safe and feasible, it could effectively reduce postoperative complications of thyroidectomy, and protect parathyroid and it’s function, recurrent laryngeal nerve, and superior laryngeal nerve.

    Release date:2018-02-05 01:53 Export PDF Favorites Scan
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