颈淋巴结清扫术后乳糜漏是颈部外科手术后比较少见的并发症，国内、外文献［1-7］报道其发生率约为1%～3%，其原因很明确，即术中损伤胸导管或其分支。颈淋巴结清扫术后乳糜漏对生命有潜在威胁，且显著延长患者住院时间、增加医疗费用。尽管手术方法及手术器械不断改进，其发生率并没有明显降低，对于部分难治性乳糜漏目前还没有简单有效的办法。现就颈淋巴结清扫术后乳糜漏的预防及治疗方法介绍如下……
Objective To investigate the depiction rate of normal cisterna chyli and thoracic duct by nonenhanced MR lymphography and to describe their appearances on MR imaging. Methods Special MR hydrography sequence was added to the MR imaging protocols of 112 patients undergoing MR examination of the thorax and upper abdomen. MR imaging sequences included: ①Respiratory-gated HASTE T2W sequence; ②Breath-hold FLASH T1W sequence; ③Respiratory-gated TSE 3D T2W sequence (3D MR hydrography sequence) in coronal plane. One hundred cases who met the inclusion criteria were included into the study for observation of the depiction rate, location and morphology of cisterna chyli and thoracic duct. Results On TSE 3D T2W imaging： ①Cisterna chyli was visualized in 71/100 (depiction rate 71.0%), morphologically including single-tube type 43.7% (31/71), bifurcation type (2-3 tubes) 23.9% (17/71), plexus type 32.4% (23/71). Average length of the cisterna chyli was 4.5 cm. ②The depiction rate of the lower segment of thoracic duct was 57.0% (57/100), average ductal diameter was 0.23 cm. ③The depiction rate of upper segment of the thoracic duct was 31.0% (31/100). Conclusion As a noninvasive method for depicting the lymphatic system, nonenhaced MR lymphography (TSE 3D T2W sequence) demonstrated a high depiction rate for cisterna chyli and lower thoracic duct. Combined with axial images of HASTE and FLASH sequences, the location and morphology of these larger lymphatic ducts can be defined.
Thoracic duct is the largest lymphatic vessel in the body. It originates from the chyle pool in the abdominal cavity, upward across aortic hiatus of the diaphragm into the right thoracic cavity, and finally importing into the left jugular vein angle. Thoracic duct plays a very important role in the transporting process of the body's lymph and chylous fluid. More than 70% of the lymph and chylous fluid transport through it into the blood. If the thoracic duct was damaged, it would lead to fluid and electrolyte imbalance, immune dysfunction, malnutrition and the patient's life would be endangered when it was serious. Therefore, the clinical significance of the thoracic duct is always a hot research issue. Through unremitting exploration in recent years, we have a further understanding about structure and function of the thoracic duct. And we used this to remould and ligate it to cure some intractable disease. Now we summarize the research progress as follows.
ObjectiveTo study the effect of preoperative oral administration of olive oil in the patients with laparoscopic resection of esophageal carcinoma and to expose the advantages of alimentary duct in operation. MethodsWe retrospectively analyzed the clinical data of 136 patients in our hospital from June 2013 through June 2015 year. There were 83 males and 53 females at age of 58.3±7.6 years. The patients were given oral olive oil 100 ml at preoperative 12 hours. ResultsAll patients completed surgery successfully without transfer to open chest. Operation of thoracic duct filling was transparent, milky white, and with clear exposure. Thoracic duct was retained successfully in the 131 patients. It was found that intraoperative injury during separation of thoracic duct due to tumor invasion in 5 patients. These patients were treated with by titanium clipping. All the patients were with chest tube drainage for 3-5 d. Average drainage volume at postoperative 24 hours was 150±35 ml. Postoperative total drainage volume was 500±130 ml. None of postoperative chylothorax was found. Postoperative average hospitalization time was 9±2 d. ConclusionEsophageal cancer preoperative oral administration of olive oil is simple, safe, effective, no injury, and with clear exposure in thoracic duct in operation. Injury of the thoracic duct is reduced. The integrity of thoracic duct is preserved. Normal glucose and lipid metabolism is retained. Therefore, it is a good choice in preoperative preparation for esophageal cancer patients. It is worth popularization and application.
ObjectivesTo compare the clinical efficacy of different surgical thoracic duct management on prevention of postoperative chylothorax and its impact on the outcome of the patients. MethodsWe searched the electronic databases including PubMed, The Cochrane Library (Issue 4, 2016), Web of Science, CBM, CNKI, VIP and WanFang Data to collect randomized controlled trials (RCTs), cohort studies and case-control studies related to the comparison of different surgical thoracic duct management during esophagectomy on prevention of postoperative chylothorax from inception to May 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then RevMan 5.2 software was used for meta-analysis. ResultsTwenty-three trials were included, involving four RCTs, four cohort studies and 15 case-control studies. The results of meta-analysis indicated:(1) Prophylactic thoracic duct ligation group had lower incidence of postoperative chylothorax compared with non thoracoic duct ligation group (RCT:OR=0.20, 95%CI 0.09 to 0.47, P=0.000 02; Co/CC:OR=0.20, 95%CI 0.14 to 0.28, P<0.000 01); (2) There were no significant differences between the two groups in the respect of mortality, morbidity and the 2-year, 3-year, 5-year survival rates (all P values >0.05); (3) Prophylactic thoracic duct ligation could reduce the reoperation rate of chylothorax complicating esophageal cancer patients (RCT:OR=0.17, 95%CI 0.10 to 0.28, P<0.000 01; Co/CC:OR=0.18, 95%CI to 0.11 to 0.32, P<0.000 01), and increase the cure rate of expectant treatment on them (OR=0.25, 95%CI 0.11 to 0.56, P=0.000 8); (4) En bloc thoracic duct ligation group had a lower incidence of postoperative chylothorax compared with single thoracic duct ligation group (OR=3.67, 95%CI 1.43 to 9.43, P=0.007). ConclusionProphylactic thoracic duct ligation during esophagectomy could effectively reduce the incidence of postoperative chylothorax and is good for reducing the reoperation rate of chylothorax complicating esophageal cancer patients. En bloc thoracic duct ligation has a better efficacy on prevention of postoperative chylothorax compared with single thoracic duct ligation.
目的 探讨经右胸入路胸腔镜下胸导管结扎在乳糜胸治疗中的作用及优势。 方法 回顾性分析南京军区南京总医院心胸外科 2012～2014 年采用胸腔镜手术治疗乳糜胸 18 例患者的临床资料，男 15 例、女 3 例，年龄 56～79（66.56±6.43）岁。所有患者均采用右胸入路胸腔镜辅助下行胸导管结扎，术中若能找到明显破口，则在破口的两端用 Ham-lock 夹闭胸导管，若未能找到明确的胸导管破口，则在第 8、第 9 胸椎附近用 Ham-lock 将胸导管及周围脂肪组织一起夹闭。 结果 全组 18 例患者均完成手术，无中转开胸，手术时间 28～45（35.83±4.58）min，术后胸腔引流时间 2～5（3.33±1.03）d，术后住院时间 5～8（6.11±1.02）d。术后无感染、吻合口瘘等严重并发症，随访 3 个月无复发。 结论 经右胸入路胸腔镜辅助手术结扎胸导管治疗乳糜胸是一种安全、有效的治疗方法，因其微创、住院时间短、手术效果确切等优点，值得在临床上推广。
ObjectiveTo investigate the impact of thoracic duct ligation (TDL) on metabolism and postoperative complications during esophagectomy in patients with type-2 diabetes mellitus (T2DM).MethodsWe conducted a retrospective clinical data analysis of 230 esophageal carcinoma patients with T2DM who underwent esophagectomy in our hospital from January 2003 to December 2018. Patients were divided into a TDL+ group (n=112), including 78 males and 34 females aged 63.47±7.23 years, and a TDL– group (n=118), including 84 males and 34 females aged 64.38±7.57 years. We compared the blood glucose, liver function parameters and lipid metabolic parameters at different time points before and after surgery. In addition, we compared the postoperative major complications between the two groups. Propensity score-matched (PSM) was used to control the observed confounders.ResultsCompared with the TDL– group, patients in TDL+ group had higher blood glucose level (P<0.05, except the fourth postoperative day). The total protein and albumin levels on the first and fourth postoperative days in the TDL+ group were lower than those in the TDL– group (P<0.05). The alanine transaminase (P=0.027) and aspartate transaminase (P=0.007) levels on the fourth postoperative day in the TDL+ group were higher than those in the TDL– group. More pulmonary complications (P=0.014) and anastomotic leaks (P=0.047) were found in the TDL+ group.ConclusionGiven that TDL may aggravate metabolic disorders, increase anastomotic leaks and the pulmonary complications, it is cautious to perform TDL, and prophylactic TDL should not be performed routinely for patients with T2DM.