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find Keyword "脑血管疾病" 8 results
  • Effect of B Vitamins Supplementation on Cardiovascular and Cerebrovascular Disease by Lowering Plasma Homocysteine Concentration: A Meta-analysis

    Objective To assess the effect of B vitamins supplementation on cardiovascular and cerebrovascular diseases, and also to evaluate the relationship between homocysteine and risk of cardiovascular and cerebrovascular diseases. Methods Using the words ‘homocysteine’, ‘cardiovascular disease’, ‘cerebrovascular disease’, ‘B vitamins’, and ‘randomized controlled trial’, we searched PubMed, Ovid, and Springer. We also hand searched relevant journals and conference proceedings. Randomized controlled trials published between 1998 and July 2008 which evaluated the effect of B vitamins supplementation on vascular diseases were collected. Two reviewers independently screened trials, extracted data, and evaluated the quality of included trials. The Cochrane Collaboration’s RevMan 4.2 software was used for statistical analysis. Results Sixteen trials involving 27,043 patients with vascular disease were included. Results of meta-analyses showed that no significant differences were identified between the B vitamins group and the control group for each of the four endpoints, including the risk of cardiovascular events (RR 0.98, 95%CI 0.94 to 1.03), the risk of coronary heart disease (RR 0.99, 95%CI 0.92 to 1.07), the risk of stroke (RR 0.90, 95%CI 0.80 to 1.02), and the total mortality (RR 0.98, 95%CI 0.92 to 1.05). Sensitivity analyses conducted by a random effect model or with the exclusion of low-quality trials did not change the overall results. Conclusion  The trials currently available cannot confirm the causal relationship between homocysteine and risk of cardiovascular and cerebrovascular diseases. More evidence from large-scale randomized controlled trials is needed to confirm this. There is not sufficient evidence to show that B vitamins supplementation can lower the risk of cardiovascular and cerebrovascular diseases. B vitamins supplementation should not be recommended for the secondary prevention of such diseases.

    Release date:2016-08-25 03:36 Export PDF Favorites Scan
  • 载脂蛋白J在脑血管疾病中的研究进展

    摘要:载脂蛋白 J(Apo J) 是新近发现的一种新型载脂蛋白,其结构与 Lipocalin家族相关联。Apo J优势表达于高密度脂蛋白中,载脂蛋白J与载脂蛋白AI一起形成高密度脂蛋白(HDL)复合物,参与末端补体反应,为神经细胞和内分泌细胞颗粒的成分.人类Apo J基因在人体组织中广泛存在,在大脑 、肾上腺髓质、垂体前叶和后叶、卵巢、睾丸及肝脏中的mRNA水平很高,胸腺、脾、肾、肺、心、乳腺及膀胱等较低。Apo J参与多种生理过程,在许多病理过程中也有所表达。本文主要介绍载脂蛋白 J在脑血管疾病方面的研究现状及功能:参与脂质转运,在胆固醇逆向转运中起重要作用;对抗动脉粥样硬化起着协同的作用;与组织的损伤修复有关、抑制补体活化及保护细胞膜等功能。目前载脂蛋白 J在脑血管疾病方面的研究尚处在探索中,取得了一定进展,现对载脂蛋 白J的研究近况作一综述。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • 优质护理在神经内科门诊脑血管疾病中的应用效果研究

    目的探讨神经内科门诊优质护理对脑血管疾病康复期患者的临床护理效果。 方法对2011年1月-2月结束住院治疗后门诊随访的100例首发脑血管疾病患者分别采用常规护理(对照组)和优质护理(干预组),两组各50例。对照组实施常规护理;干预组采用优质护理,主要包括采取心理护理、健康教育、康复指导、家庭干预以及定期电话随访等综合护理干预措施。随访1年后比较两组护理效果。 结果干预组35例完全恢复,11例部分恢复,4例未恢复;对照组22例完全恢复,13例部分恢复,15例未恢复;两组差异有统计学意义(Z=2.951,P=0.003)。干预组40例对护理满意度,8例较满意,2例不满意;对照组28例满意,12例较满意,10例不满意;两组差异有统计学意义(Z=2.750,P=0.006)。干预组复发8例(16.0%),对照组复发20例(40.0%),两组差异具有统计学意义(χ2=7.143,P=0.008)。 结论优质护理在神经内科门诊脑血管疾病患者护理中效果较好,值得推广使用。

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  • Health Technology Assessments on Cardiovascular and Cerebrovascular Diseases among Rural China: A Systematic Review

    ObjectiveTo comprehensively review the status quo, contents, and problems of health technology assessments (HTAs) on cardiovascular and cerebrovascular diseases in Chinese rural. MethodsThe CNKI, VIP, WanFang Data and CBM databases were searched for the HTAs on cardiovascular and cerebrovascular diseases in Chinese rural up to October 31st, 2013. Two reviewers independently screened literatures and extracted data, and then the qualitative method was used to systematically analyze the literatures' information and results. ResultsA total of 34 studies were included. Of which, 23 were descriptive studies and 11 were experimental studies. The studied populations were patients and ordinary residents who had received the service of cardiovascular and cerebrovascular diseases health technology in rural, as well as the grassroots medical technical personnel and promotion staffs who had developed the health technologies. HTAs on cardiovascular and cerebrovascular diseases in rural mainly included western medicine health technologies and traditional Chinese medicine (TCM) health technologies. The contents of HTA of the included literatures mainly included:effectiveness, acceptability, requirements, economic characteristics, safety and technical specific property. The results of the included literatures showed that the type of diseases involved in cardiovascular and cerebrovascular diseases in rural were not widely enough, the fields involved in assessment contents were single, lack of rigorous and comprehensive study design. ConclusionWe need more HTAs of cardiovascular and cerebrovascular diseases in rural, we also need to strengthen early prevention, promote a wider range of cardiovascular and cerebrovascular diseases health technology, strengthen promotion and application of both TCM health technologies and the combination of TCM and western medicine health technologies in cardiovascular and cerebrovascular diseases.

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  • Effectiveness of Yindan Xinnaotong capsule in the treatment of cardiovascular and cerebrovascular diseases: a meta-analysis

    Objective To systematically review the effectiveness of Yindan Xinnaotong capsule for cardiovascular and cerebrovascular diseases. Methods We electronically searched databases including PubMed, MEDLINE, CBM, CNKI, VIP, WanFang Data for published articles of randomized controlled trials (RCTs) of Yindan Xinnaotong capsule plus conventional drugs versus conventional drugs for cardiovascular and cerebrovascular diseases from inception to April, 2016. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 62 RCTs involving 6 306 patients with cardiovascular and cerebrovascular diseases were included. The results of meta-analysis showed that the improvement of symptoms, such as the total clinical effective rate of cerebrovascular disease indications (stroke) (RR=1.25, 95% CI 1.19 to 1.31,P<0.000 01), and the total clinical effective rate of cerebrovascular disease (ischemic headache) indications (RR=1.27, 95% CI 1.17 to 1.38,P<0.000 01), and the total clinical effective rate of coronary heart disease and angina pectoris (RR=1.21, 95% CI 1.17 to 1.25,P<0.000 01), were superior in the combination arm to the conventional drugs alone arm. Conclusion The current evidence shows that the combination of Yindan Xinnaotong capsule and conventional drugs may significantly improve the effectiveness. Due to the limited quality and quantity of the included studies, the above conclusions need more high quality studies to verify.

    Release date:2017-04-24 03:30 Export PDF Favorites Scan
  • Advances on clinical researches of cerebrovascular diseases in 2017

    Substantial progresses have been made in cerebral vascular diseases in 2017. By retrospectively analyzing the clinical researches which Chinese experts participated in or were in charge of, this article briefly summarizes the update of stroke epidemiology, explorations of stroke-related risk factors, early management of acute stroke, secondary prevention and prognosis of stroke. These researches include the problems about the dose of thrombolysis medicine, new type of antiplatelet and anticoagulant drugs, prognosis of intracranial hemorrhage and signs of intracranial hematoma enlargement, which have close connection with clinical work and are valuable in practice.

    Release date:2018-06-26 08:57 Export PDF Favorites Scan
  • Research status of the relationship between telomeres and cardiovascular and cerebrovascular diseases

    Telomeres play an important role in maintaining genomic stability and cell life. Accumulating studies show that telomeres are closely related to human aging, cardiovascular diseases and cerebrovascular diseases. There are a series of researches about telomeres and atherosclerosis across the world, including studies on the relationship between atherosclerosis, cardiovascular diseases, cerebrovascular diseases and telomere length, and on telomere-targeted treatments for cardiovascular and cerebrovascular diseases. Telomeres may be a risk predictor or a new therapeutic target for atherosclerosis and cardiovascular diseases. This article reviews the relationship between telomeres and cardiovascular and cerebrovascular diseases, introduces the research progress of telomere length and cardiovascular diseases, cerebrovascular diseases, and the possible mechanisms of their association, aiming to provide a theoretical basis for exploring new therapeutic targets for atherosclerosis.

    Release date:2019-11-25 04:42 Export PDF Favorites Scan
  • Chronic cough and risk of cerebrovascular disease: a prospective cohort study

    Objective To explore the association between cough patterns and cerebrovascular disease risk, and to provide epidemiological evidence for the early diagnosis and prevention of cerebrovascular disease. Methods During the period from 2010 to 2012 in Guizhou Province, a multi-stage proportional stratified cluster sampling method was used to recruit people with the inclusion criteria of the study into a cohort and a baseline questionnaire for demographic information, lifestyle, and disease history was administered. The incidence of cerebrovascular disease was followed up from 2016 to 2020. Results A total of 4804 subjects were followed up, and 4589 (53.5% were female) subjects were enrolled in final investigation. Compared with non-chronic cough group, there was no statistical significance in the risk of cerebrovascular diseases (P>0.05), however, chronic cough (the risk ratio was 2.00 and the 95% confidence interval ranged from 1.08 to 3.69) was twice as likely to develop cerebrovascular disease as non-cough. Conclusions People with chronic cough are more likely to develop cerebrovascular disease than people without cough. More attention to the management and control of cough should be paid to avoid chronic cough, so as to reduce the risk of cerebrovascular diseases.

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