ObjectiveTo explore the status of the career maturity of medical students (eight-year program) and its related factors. MethodsFrom April to June in 2010, College Students Maturity Self-test Questionnaire was used for the investigation of the career maturity of the medical students (eight-year program) at West China Medical School of Sichuan University. ResultsThe subjects were graded into three groups according to the scores of their questionnaires:high, moderate, and low career maturity. The proportion of each group was 15.2%, 13.8%, 71.0%, respectively. Gender difference was not found in the overall career maturity (Z=-0.206, P=0.837), while there was positive correlation between grade and overall career maturity (rs=0.180, P=0.030). ConclusionThe medical students (eight-year program) with relatively low overall career maturity account for a larger proportion than those with high and median career maturity. As grade increases, career maturity changes significantly. This research suggests that long schooling medical students are in urgent need for prompt and valid professional career education.
目的 探讨脂多糖（LPS）、白细胞介素-6（IL-6）和血小板活化因子（PAF）与重症胸腹创伤后凝血功能紊乱发生的相关性及可能的致病机理。方法 收集2009年1月至2011年12月期间在中国人民解放军第二五三医院急诊科就诊、创伤指数≥17分且除外合并颅脑损伤及在急诊科内死亡的胸腹创伤患者62例，在予以抢救、治疗的同时抽血检查血小板计数（PLT）、血浆D-二聚体（D-D）、部分活化凝血酶原时间（APTT）、凝血酶原时间（PT）、LPS、IL-6和PAF，并对其结果进行相关性分析。结果 本组患者就诊时检测的PLT为（157.73±78.11）×109/L， D-D为（1 023.88±208.72） U/L，APTT为（46.95±17.85） s，PT为（19.44±6.95） s，TT为（58.27±12.44）s，除PLT降低外，其余4项指标均升高或延长； LPS为（322.85±104.54） U/L，IL-6为（285.51±81.46） ng/mL，PAF为 （14 714.70±4 427.95） ng/L， 三者均升高； PLT与LPS、IL-6和PAF之间呈负相关关系（P＜0.001），而D-D、APTT、PT和TT与LPS、IL-6和PAF之间均呈正相关关系（P＜0.001）。结论 LPS、IL-6及PAF可能参与了重症胸腹创伤后凝血功能障碍的发生；重症胸腹损伤后出现的微循环障碍及内毒素血症是凝血功能障碍发生的重要机理。针对LPS、IL-6和PAF进行早期干预，有可能改善重症胸腹创伤患者的凝血功能障碍。