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find Author "薛文东" 2 results
  • 影响吸入粉雾剂疗效发挥的因素分析

    随着近几年医药技术的高速发展, 人们对药物的疗效及安全性有了进一步的认识, 人们已经意识到药物的疗效及安全性不仅与药物本身的化学结构有关, 而且同一药物因剂型差异、给药途径不同也会对其疗效及安全性产生比较大的影响。口服给药和注射给药虽然是大多数治疗药物采用的给药途径,但许多口服给药产品在进入体循环之前就被降解,增加了给药的剂量和不良反应的发生率, 影响了产品疗效的发挥, 注射给药虽然可以弥补口服给药的不足, 但却降低了患者的依从性, 不利于患者长期治疗。肺部给药途径由于其独特的优越性在临床上日益受到关注, 肺部巨大的表面积确保药物迅速地吸收和起效, 并不产生首过效应, 药物避免了被胃肠道消化液降解的可能, 降低了药品的给药剂量, 不会有口服制剂的剂型缺陷; 同时药物颗粒在肺泡沉积后也可形成较长的体内滞留时间, 降低了给药的频率,减少了使用的不适, 提高了患者的依从性, 不会引起注射给药的不足[ 1 ] 。这些特点使得越来越多的药物采用或准备采用肺部给药途径, 治疗领域由传统的抗哮喘和慢性阻塞性肺疾病( COPD) 药物扩展到祛痰、抗结核、抗癌、止痛等局部或全身治疗领域。

    Release date:2016-09-13 03:54 Export PDF Favorites Scan
  • ANATOMY FIT AND OPTIMIZED DESIGN OF THE INTERFACE BETWEEN PRESS-FIT HIP AND BONE

    Objective To improve the fitness and initial fixation strength between the hip and bone and to optimize the shape of the prosthetic implants. Methods The cross-section of hip canal was automatically extracted by Image processing. By using taper curve fit,hypocurve predigesting and the curve of shape center fit, the parameters of long-short diameter and the curve of shape center were got to design the hip shape.CAD was adopted to analyze and evaluate the configuration of bone and shape of hip.The “peg-in-hole” was employed to optimize the shape of implant by the visual test of “Drawingout” in computer. Results 23.2% hip-bone average matching rate and 0.033% bone damage rate were presented by CAD analysis. The implant extraction path were validated visually and quantitatively by measuring the maximum amount of overlap in the path configuration. Conclusion The valuable method for prothsetic hip design was presented by the way of image processing,graphics design and optimizingdesign in this study.

    Release date:2016-09-01 09:28 Export PDF Favorites Scan
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