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find Keyword "血尿酸" 6 results
  • 高血压患者全血低切变黏度和血尿酸水平及颈动脉内-中膜厚度与心肌梗死的相关性

    目的 分析原发性高血压(EH)患者颈动脉内-中膜厚度(IMT)与全血低切变黏度及血尿酸水平的关系,以探讨心肌梗死和颈动脉斑块之间的相关性。 方法 2010年3月-2011年5月113例EH患者通过颈动脉超声检查分为IMT正常组(n=47)、增厚组(n=37)和斑块组(n=292),各组同时检测全血低切变黏度和血尿酸。 结果 正常组、增厚组和斑块组全血低切变黏度分别为(8.19 ± 2.31)、(14.88 ± 2.34)、(19.96 ± 3.81)mPa·s,各组两两比较,差异均有统计学意义(P<0.01)。正常组、增厚组和斑块组血尿酸分别为(303.26 ± 91.42)、(371.33 ± 92.12)、(416.54 ± 96.02)μmol/L,各组两两比较,差异均有统计学意义(P<0.01)。 结论 EH患者IMT随全血低切变黏度和血尿酸水平升高而增厚,通过以上的检查和检测从而达到对心肌梗死的早发现早治疗。

    Release date:2016-09-07 02:38 Export PDF Favorites Scan
  • The Relationship between Serum Uric Acid and Insulin Release and Sensitivity

    目的 探讨血尿酸与胰岛素分泌和敏感性的关系。 方法 对成都市龙泉驿区2007年6月-7月间20~75岁常住自然人群565人进行人口学、腰围、臀围、血压、75 g葡萄糖耐量及胰岛素测定(0、30、120 min),血脂、血肌酐及血尿酸检测。以早期胰岛素分泌功能指数(△I30/△G30)和葡萄糖处置指数(DIo)代表胰岛素分泌功能,以Matsuda 指数代表胰岛素敏感性,分别与血尿酸进行相关性研究。 结果 男性的血尿酸与年龄呈负相关,与舒张压、葡萄糖负荷后120 min胰岛素和甘油三酯呈正相关。女性的血尿酸与甘油三酯、低密度脂蛋白、血肌酐呈正相关,与高密度脂蛋白、Matsuda指数呈负相关。无论男性和女性,均未发现血尿酸与△I30/△G30、DIo相关。 结论 女性的胰岛素敏感性下降与血尿酸升高有关。未发现血尿酸与胰岛素分泌有相关关系。

    Release date:2016-09-07 02:38 Export PDF Favorites Scan
  • 158例2型糖尿病患者血脂与血尿酸代谢异常关系分析

    目的:探讨2型糖尿病患者血脂与血尿酸代谢的关系;方法:对158 例2型糖尿病患者(观察组及101 例正常对照组)进行血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白A(APoA)、载脂蛋白B(APoB)、血尿酸(UA)测定;结果:观察组TG、APoB、UA明显高于对照组,观察组HDL-C、APoA明显低于对照组。结论:2型糖尿病患者易发生脂代谢异常,而血脂、血糖、血尿酸异常的共存是该病发生的危险因素,也是心脑血管疾病的危险因素。因此,及时纠正血脂、血尿酸代谢异常对2型糖尿病的治疗就显得十分重要。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • Association Between Sreum Uric Acid Concentration and Blood Pressure, Triglycerides in Old People with MS

    目的:探讨老年代谢综合征者血清尿酸与血压、甘油三脂的关系。方法:163例入选者,MS组96例,对照组67例,对二组的SUA、BMI、WC 、SBP、DBP及TG进行分析。结果:MS组SUA较对照组高。MS组男性SUA与BMI正相关、女性与WC正相关;男女性MS组及对照组SUA与SBP及TG不相关。对照组女性SUA与DBP正相关。结论:SUA对老年女性DBP的维持可能有一定作用。TG对老年人SUA的影响有限;体重及脂肪聚集部位对SUA的影响,存在性别差异。

    Release date:2016-09-08 10:01 Export PDF Favorites Scan
  • Analysis of the effect of asymptomatic hyperuricemia on the effectiveness after arthroscopic rotator cuff repair

    ObjectiveTo investigate the effect of asymptomatic hyperuricemia on the effectiveness of arthroscopic rotator cuff repair.MethodsThe clinical data of 80 patients who underwent arthroscopic rotator cuff repair and met the selection criteria between March 2018 and December 2019 were retrospectively analyzed. According to the serum uric acid level, the patients were divided into hyperuric acid group (46 cases, the serum uric acid level was more than 417 μmol/L in males and was more than 357 μmol/L in females) and normal group (34 cases, serum uric acid level was lower than the above standard). There was no significant difference in gender, age, side, body mass index, blood glucose level, total cholesterol level, rotator cuff tear size, and preoperative shoulder motion, visual analogue scale (VAS) score, University of California-Los Angeles (UCLA) score, Constant score, American Shoulder and Elbow Surgeons (ASES) score, and other general data between the two groups (P>0.05). The range of motion of abduction, forward flexion, and external rotation at 90° abduction were recorded and compared between the two groups before operation and at last follow-up; the improvement of shoulder pain was evaluated by VAS score; the improvement of shoulder function was evaluated by UCLA score, Constant score, and ASES score; and the shoulder joint MRI grade was evaluated according to Sugaya evaluation criteria.ResultsAll patients were followed up 9-16 months, with an average of 11.9 months; there was no significant difference in the follow-up time between the two groups (t=0.968, P=0.336). There were 2 cases of retear in the hyperuric acid group (including 1 case of severe tear) and 1 case of light retear in the normal group. The remaining patients in the two groups had no early-related complications. At last follow-up, the range of motion of the shoulder joints (abduction, forward flexion, external rotation at 90° abduction), VAS score, UCLA score, Constant score, and ASES score of the two groups were significantly improved when compared with preoperative ones (P<0.05); the above indicators in the normal group were significantly better than those in the hyperuric acid group (P<0.05). The MRI grade of the shoulder joint in the normal group was significantly better than that in the hyperuric acid group (Z=–2.000, P=0.045).ConclusionCompared with patients with normal serum uric acid level, asymptomatic hyperuricemia can lead to worse recovery after arthroscopic rotator cuff repair in patients with rotator cuff tears.

    Release date:2021-06-30 03:55 Export PDF Favorites Scan
  • Homocysteine and serum uric acid levels in type 2 diabetic retinopathy and their predictive value for disease

    Objective To observe the correlation between homocysteine (Hcy) and serum uric acid (SUA) and retinopathy in type 2 diabetes mellitus (T2DM), preliminary study on its predictive value. MethodsA retrospective study. From January 2020 to March 2021, a total of 324 T2DM patients hospitalized in Department of Endocrinology, Cangzhou Central Hospital of Hebei Province were included. Fasting blood glucose (FBG), glycated hemoglobin (HbA1C), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), serum creatinine (Scr), blood urea nitrogen (BUN), Hcy, SUA, peripheral blood endothelial progenitor cells (EPC), circulating endothelial cells (CEC) were counted and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. According to the absence or presence of diabetic retinopathy (DR), the patients were divided into non DR (NDR) group and DR group with 100 and 214 cases, respectively. Clinical data and laboratory biochemical indexes of the two groups were compared and observed. The logistic regression was used to analyze the independent risk factors for DR in T2DM patients. Smooth curve fitting was used to analyze the curve relationship between Hcy, SUA and DR, and ROC area (AUC) of Hcy, SUA; their combined prediction of DR in T2DM patients was calculated by receiver operating characteristic curve (ROC curve), and the predictive value of Hcy and SUA for DR in T2DM patients was evaluated. ResultsDiabetic course (t=5.380), systolic blood pressure (t=2.935), hypertension (χ2=10.248), diabetic nephropathy (χ2=9.515), diabetic peripheral neuropathy (χ2=24.501), FBG (t=3.945), HbA1C (t=3.336) and TG in DR Group (t=2.898), LDL-C (t=3.986), Scr (t=2.139), SUA (t=7.138), HOMA-IR (t=3.237), BUN (t=3.609), Hcy (t=2.363) and CEC (t=19.396) were significantly higher than those in NDR group. The difference was statistically significant (P<0.05). EPC (t=9.563) and CPC (t=7.684) levels were significantly lower than those of NDR group, and the difference was statistically significant (P<0.05). Logistic regression analysis showed that diabetes course, SBP, hypertension, FBG, HbA1C, LDL-C, SUA, Hcy, EPC, CPC and CEC were all independent risk factors for developing DR in T2DM patients (P<0.05). The smooth curve fitting analysis showed that Hcy and SUA were positively correlated with the occurrence of DR. After adjusting for confounding factors, when Hcy≥15 μmol/L, the risk of DR Increased by 14% for every 1 μmol/L increase in Hcy [odds ratio (OR)=0.92, 95% confidence interval (CI) 0.88-0.98, P<0.05]. When Hcy<15 μmol/L, there was no significant difference (OR=0.96, 95%CI 0.92-1.08, P>0.05). When SUA≥304 μmol/L, the risk of DR increased by 17%, every 20 μmol/L SUA increased (OR=0.80, 95%CI 0.68-0.94, P<0.05). When SUA<304 μmol/L, the difference was not statistically significant (OR=0.83, 95%CI 0.72-0.95, P>0.05). ROC curve analysis results showed that the AUC values of Hcy, SUA and Hcy combined with SUA in predicting the occurrence of DR in T2DM patients were 0.775 (95%CI 0.713-0.837, P<0.001), 0.757 (95%CI 0.680-0.834, P<0.001) and 0.827 (95%CI 0.786-0.868, P<0.001). Hcy combined with SUA showed better predictive efficiency. ConclusionsThe abnormal increase of Hcy and SUA levels in T2DM patients are closely related to the occurrence of DR, they are independent risk factors for the occurrence of DR. Hcy combined with SUA has high predictive value for the occurrence of DR.

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