目的 降低非典型桥本病的误诊率，选择适宜治疗。方法 回顾性总结1981年至1997年间收治的非典型桥本病84例。结果 84例中仅16例未手术，余68例均手术。术后病理结果： 单纯桥本病43例，桥本病合并其他甲状腺疾病： 甲状腺腺瘤4例，结节性甲状腺肿瘤14例，甲状腺机能亢进症3例，甲状腺癌4例。结论 本病误诊率较高，将检测抗甲状腺球蛋白抗体和抗微粒体抗体、细针穿刺活检和甲状腺干制剂诊断性治疗三者有机结合有助于提高本病的正确诊断率； 对于桥本病有压迫症状或合并其他甲状腺疾病者，可予手术治疗； 术中行冰冻病理检查可明确诊断并确定手术方式，术中应尽量保留正常甲状腺组织，以防形成甲状腺功能减低。
【Abstract】Objective To investigate the effects of ethanol on polarization of cultured hepatocytes.Methods Sandwich hepatocytes were used to study the effects of ethanol on polarization of shortperiod cultured hepatocytes. Expression of albumin mRNA and P450-b mRNA,specific distribution of plasma membrance protein and the morphology were observed before and after ethanol was given. Results After treated ethanol, hepatocytes became flat and polynuclear. Its cellular plasma became watery and anatomical networks like board structure disappeared. Immunohistochemical method proved that the distribution of specific plasma membrane protein was damaged, and in situ hybridization studies demonstrated that the levels of albumin mRNA, P450-b mRNA expression decreased after ethanol was given.Conclusion Ethanol induces significant disturbance of cell polarization in cultured hepatocytes to result in injury. The current study is important for exploring the mechanism of alcohol liver disease from the cellular plane to provide a model.