目的总结肛周坏死性筋膜炎（PNF）的临床特点、诊断及治疗方法。 方法回顾性分析我院肛肠外科2007年1月至2012年12月期间收治的22例PNF患者的临床资料。 结果全部病例均行手术治疗，术中彻底清创，术后给予抗炎、对症、支持治疗。痊愈18例，死亡4例。痊愈病例随访6个月未见复发。 结论PNF早期临床表现无特异性，诊断主要依据临床表现及相关影像学检查，治疗以手术为主，早期诊断，及时治疗，是治愈PNF、降低死亡率的关键。
目的观察吻合器痔上黏膜环形切除钉合术(procedure for prolapse and hemorrhoids，PPH)治疗老年女性患者直肠前突的临床疗效。方法回顾性分析我科2004年10月至2010年8月期间经PPH治疗的63例老年女性直肠前突患者的手术经过及术后疗效。结果本组63例患者手术均顺利，手术时间13～35 min (平均21 min)，住院时间3～7 d (平均5 d)，无直肠阴道瘘、肛周脓肿等并发症发生。术后2周均行肛门指诊，2例有轻度炎症，给予对症治疗1周后炎症消失。3例吻合钉未完全脱净，少量残留，给予取出残钉后不适症状消失。术后随访0.5～5年（平均3年），随访率为95.24%(60/63),临床症状完全消失61例，治愈率为96.83%； 症状好转2例，对好转的2例行排粪造影检查，前突均明显减轻，且便秘症状较前有所缓解。结论PPH治疗老年女性直肠前突安全、有效，便秘症状缓解明显，是一种适合临床应用的手术方式。
目的 观察吻合器痔上黏膜环形切除钉合术（PPH）治疗直肠前突所致便秘的临床疗效。方法 回顾性分析我科2008年1月至2012年1月期间经PPH治疗的104例女性直肠前突致便秘患者的手术经过及术后疗效。结果 本组104例均手术顺利，手术时间13～35min，平均21min；住院时间3～7d，平均4.5d；无直肠阴道瘘、肛周脓肿、肛门狭窄等并发症发生。术后2周均常规行肛门指检，3例局部轻度炎症，给予抗炎对症治疗后症状消失。5例吻合口局部吻合钉未完全脱落，给予取出后不适症状消失。术后随访1～5年（平均3年），随访率为97.12%（101/104），临床症状完全消失99例，治愈率为95.19%；症状好转5例，该5例行排粪造影检查，直肠前突均明显减轻，且便秘症状明显缓解。结论 PPH治疗女性直肠前突所致便秘安全、有效，便秘症状缓解明显，是一种适合临床应用的手术方式。
Objective To evaluate the safety and efficacy of procedure for prolapse and hemorrhoids （PPH） combined with Shaobei injection in treatment for obstructed defecation syndrome （ODS） caused by rectocele. Methods Seventy-two female patients with rectocele from December 2009 to January 2011 in this hospital were divided into PPH combined with Shaobei injection group （36 cases） and only PPH group （36 cases）. The Longo ODS score was performed on week one，month one，month three，and month six after operation，respectively；pain was evaluated， complications such as urine retention，postoperative bleeding，and anal function were observed；hospital stay and recovery work time were recorded in two groups. Results All patients were followed up for 6 months，there were no significant differences in complications，hospital stay，and the Longo ODS score on week one and month one after operation between two groups （P＞0.05）. But the Longo ODS score of the PPH combined with Shaobei injection group on month three and month six after operation were significantly lower than those of the only PPH group （P＜0.05）. Conclusion PPH combined with Shaobei injection has a better efficacy as compared with only PPH，and at least as safe as only PPH.
目的 评价注射用英夫利西单抗治疗难治性溃疡性结肠炎（UC） 的疗效。方法 回顾性分析2009年10月至2012年10月期间，在中国医科大学附属第四医院肛肠外科住院并接受注射用英夫利西单抗治疗的9例中重度激素难治性UC患者的临床疗效。结果 经注射用英夫利西单抗治疗后，7例中度UC患者中，1例完全缓解，4例有效，1例疗效不详，1例无效；2例重度UC者中，1例有效，1例无效。临床缓解及治疗有效的6例患者的血红蛋白水平较治疗前上升，红细胞沉降率及C反应蛋白水平均下降。3例具有肠外表现者的肠外症状均得到改善。结论 对于激素抵抗或激素依赖的中重度UC患者，注射用英夫利西单抗可以有效缓解患者的临床症状。
In view of the fact that medical inspection equipment sold in the domestic market is mainly imported from abroad and very expensive, we developed a full-automatic fluorescence analyzer in our center, presented in this paper. The present paper introduces the hardware architecture design of FPGA/DSP motion controlling card+PC+STM32 embedded micro processing unit, software system based on C# multi thread, design and implementation of double-unit communication in detail. By simplifying the hardware structure, selecting hardware legitimately and adopting control system software to object-oriented technology, we have improved the precision and velocity of the control system significantly. Finally, the performance test showed that the control system could meet the needs of automated fluorescence analyzer on the functionality, performance and cost.
The rehabilitation experience of 20 patients with tracheostomy after lung transplantation was reported, and the key points of rehabilitation nursing included sequential oxygen therapy, airway clearance, diaphragm pacing, respiratory training, swallowing training, speech training, exercise training, and gastrointestinal function rehabilitation. Tracheostomy is conducive to airway management and offline extubation in patients assisted by long-term breathing, and promotes patient recovery and discharge through multidisciplinary collaborative rehabilitation nursing integrated case management.
ObjectiveTo investigate the value of noninvasive positive pressure ventilation in patients with high risk of weaning induced pulmonary oedema.MethodsFrom June 2018 to June 2019, 63 patients with mechanical ventilation in the Department of Critical Care Medicine of the First Hospital of Lanzhou University were enrolled. Randomized digital table method was randomly divided into two groups and the resulting random number assignment was hidden in opaque envelopes, the experimental group received non-invasive positive pressure ventilation (n=32), and the control group received mask oxygen therapy ventilation (n=31). The heart rate, respiratory rate, means arterial pressure, hypoxemia, reintubation, blood gas analysis and other indicators were compared between the two groups after 2 hours of weaning. The length of hospital stay, mortality and complications were compared between the two groups.ResultsAfter 2 hours of weaning, the heart rate and respiratory rate were significantly lower in the non-invasive positive pressure ventilation group than in the mask group (P<0.05). There was no difference in mean arterial pressure between the two groups of patients, which was not statistically significant (P>0.05). The incidence of hypoxemia, laryngeal edema and reintubation in the noninvasive positive pressure ventilation group was significantly lower than that in the mask group, which was statistically significant (P<0.05), and the blood gas analysis index was better than the mask group (P<0.05). The non-invasive positive pressure ventilation group was significantly shorter than the mask group in the length of hospital stay and intensive care unit (P<0.05). The hospital mortality rate in 28 days was lower than that in the mask group (P<0.05), but there was no difference in tracheotomy, pneumothorax and subcutaneous emphysema between the two groups (P>0.05).ConclusionsNoninvasive positive pressure ventilation can effectively prevent hypoxemia, laryngeal edema, and re-intubation in patients at high risk of withdrawal related pulmonary edema. It can also shorten the length of hospital stay, which is worth clinical attention and promotion.
ObjectiveTo evaluate the effect of airway pressure release ventilation (APRV) on the hospital mortality of patients with acute respiratory distress syndrome (ARDS) by using cumulative meta-analysis. MethodsThe PubMed, Web of Science, Cochrane Library, WanFang Data, CNKI, and VIP databases were electronically searched to collect randomized controlled trials (RCTs) related to the objective from inception to June 30, 2022. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. A cumulative meta-analysis was then performed by using StataSE 12.0 software. ResultsA total of 9 RCTs involving 533 patients were included. The results of meta-analysis showed that APRV could reduce the hospital mortality of patients with ARDS (RR=0.70, 95%CI 0.54 to 0.91, P<0.01) compared with traditional mechanical ventilation. ConclusionCurrent evidence shows that APRV can reduce the hospital mortality of patients with ARDS. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.