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find Keyword "视网膜病变/病因学" 42 results
  • Relationship between diabetic retinopathy and coronary atherosclerosis in type 2 diabetes patients

    Objective To investigate the relationship between diabetic retinopathy (DR) and coronary atherosclerosis (CAS) in type 2 diabetes patients and other risk factors of DR. Methods A total of 118 patients of type 2 diabetes with DR (DR group), 120 patients of type 2 diabetes without DR matched in age and sex (non-DR group), and 86 normal controls (control group) were enrolled in this study. The body mass index (BMI), blood pressure (BP), fasting blood-glucose (FPG), glycosylated haemoglobin (HbA1C), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterin (LDL-C), creatinine, estimate glomerular filtration rate (eGFR) and urinary albumin excretion rate(UAER) in all the subjects were measured. Meanwhile, the incidence of CAS in the three groups was detected by 64slice multidetector computed tomography angiography (MDCTA). Assume concurrent DR as dependent variable, clinical indicators and laboratory parameters as independent variable, the risk factors were determined by Logistic regression analysis. In addition, CAS as dependent variable, DR as fixed factor, analysis of covariance was used to investigate the relationship between CAS and DR. Results The incidence of CAS in DR group was higher than that in nonDR group and control group, the differences were statistically significant (chi;2=26.9,35.5;P<0.05). The results of Logistic regression analysis showed that systolic BP, BMI, CAS, myocardial infarction and UAER were key risk factors for DR [odds ratio (OR)=1.02, 0.89, 4.50, 3.89, 1.34;P<0.05]. There was a negative relationship between BMI and DR. The results of analysis of covariance showed that there was significant correlation between CAS and DR (OR=5.31, 95% confidence interval=2.62-10.60; P<0.05). Conclusion CAS is independently associated with DR in type 2 diabetes patients. In addition, the other risk factors for DR include systolic BP, BMI, myocardial infarction and UAER.

    Release date:2016-09-02 05:18 Export PDF Favorites Scan
  • 糖尿病视网膜病变患者血清中血管内皮生长因子和色素上皮衍生因子水平的变化

    Release date:2016-09-02 05:18 Export PDF Favorites Scan
  • 不同分级的糖尿病视网膜病变患者血清血管生成素1和2比值变化

    Release date:2016-09-02 05:18 Export PDF Favorites Scan
  • Insulin has no effect on vascular endothelial growth factor expression in the retina of streptozotocin-induced diabetic rats

    Objective To investigate if insulin can affect the expression of vascular endothelial growth factor (VEGF) in the retina of streptozotocin-induced diabetic rats. Methods A total of 60 male SpragueDawley rats were randomly divided into sodium citrate buffer control group (CIT-CON, n=30) and STZ-induced diabetic group (STZ-DM, n=30). At the 16th week, 24 rats from CIT-CON group at random were randomly divided to group A (sodium citrate buffer control group, n=12) and group B (sodium citrate buffer plus insulin group, n=12). The remaining 6 rats from as CIT-CON group served as negative control. At the same time, 24 rats from STZDM group at random were randomly divided to group C (STZinduced diabetic group, n=12) and group D (STZ-induced diabetic plus insulin group, n=12). The remaining 6 rats from STZ-DM group also served as negative control. 4 IU of insulin was injected subcutaneously to rats of group B and D. Immunohistochemistry, Western blot and Real-time polymerase chain reaction (RT-PCR) were used to measure the expression level of VEGF protein and mRNA respectively. RESULTS Insulin significantly increased the VEGF mRNA (7.71plusmn;0.25 vs 5.36plusmn;0.37, t test Plt;0.05) and protein expression (0.4925plusmn;0.0122 vs 0.4272plusmn;0.0110, t test Plt;0.05) in the retina of CITCON rats. However, in retina of STZDM rats, insulin had no effect on VEGF mRNA (8.92plusmn;0.27 vs 9.05plusmn;0.28, t test, Pgt;0.05) and protein expression (0.5152plusmn;0.0109 vs 0.5099plusmn;0.0100, t test Pgt;0.05). Conclusions Insulin had no effect on VEGF expression in the retina of STZ-DM rats.

    Release date:2016-09-02 05:42 Export PDF Favorites Scan
  • 炎症、抗炎药物与早期糖尿病视网膜病变的关系

    糖尿病视网膜病变(DR)是糖尿病严重的微血管并发症,已成为致盲的主要因素之一。目前DR发生机制尚未明确,高血糖诱发一系列相关的功能和生化代谢异常,如血流改变、血液流变学异常、多元醇通路活化、氧化应激增多、晚期糖基化终产物积聚及细胞因子活化等受到广泛关注。近年的研究发现许多炎症因素如白细胞浸润、黏附分子及许多炎症因子的表达与早期DR的发生、发展密切相关;许多抗炎药物可通过抑制白细胞积聚、降低炎症因子表达等过程,阻止或减缓DR的发生与发展。 (中华眼底病杂志,2008,24:312-315)

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • Expressions of apoptosis-related genes of retinal blood vessel in early diabetic rats

    Objective To analyze the expression of apoptosis-related genes of retinal blood vessel in early diabetic rats by gene chip technology. Methods To make diabetic rat model by intraperitoneal injection of streptozotocin (STZ). On the 6th week after blood pressure increased, 10 rats were executed in Diabetic group and normal control group respectively. 20 retinal blood vessels were extracted and the RNA was isolated. The probe was made of alpha;-32 P-deoxyadenosine triphosphate (dATP)-labeled sample which hybridized 1176 nylon chips, and then analyzed by software. Three different expression genes were selected to verify by reverse transcription polymerase chain reaction (RT-PCR). Results On the 6th week, 136 (11.5%) genes were differentially expressed [up-regulated genes were 90(7.6%), down-regulated genes were 46(3.9%)]in diabetic group. These genes involved into different groups according to their function. Especially in 72 apoptosis-related genes, 15 genes were differentially expressed. The up-regulated genes were some TNF receptor family members such as TNFRSF12, TRAIL, TNFRSF9, FADD;Bcl-2 family members such as bcl-w, bax, bak1 and AKT. The down-regulated genes were FAF1 which related to fas. Conclusions The expression of retinal vascular gene in early diabetic rats has been changed complicatedly. In particular, the multiple apoptosis-related genes have been changed in early diabetic, and most of them are at the upstream of apoptosis pathway. These findings indicate that the development of diabetic retinopathy is associated with multiple signaling pathways leading to apoptosis, while the alterations on the level of molecular biochemistry are still limited in apoptosis induction period. (Chin J Ocul Fundus Dis,2008,24:244-248)

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • Unifying mechanism theory and choronic inflammation theory: the trend of basic researches related to diabetic retinopathy

    The pathogenesis of diabetic retinopathy (DR) is more complex. For the upstream of traditional pathogenesis, to looking for unifying mechanism theory which proposed in foundation of common promoters and the latest view of DR may be the result of chronic inflammation. Both of them provide the basic and clinical theraby of DR with new direction. Therefore, there are many related issues still needs to intensive study. (Chin J Ocul Fundus Dis,2008,24:237-239)

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • 增生性糖尿病视网膜病变玻璃体中VEGF及PEDF水平

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 增生型糖尿病视网膜病变肾上腺髓质素的表达和变化

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 氧化应激在糖尿病视网膜病变中的作用研究进展

    糖尿病性视网膜的氧自由基来源于高血糖状态下线粒体呼吸链电子传递障碍和细胞还原型辅酶Ⅱ NADPH氧化酶的异常激活,氧自由基通过激活聚腺苷二磷酸核糖聚合酶(PARP)参与或者促发多元醇、蛋白激酶C、糖基化终末产物、氨基己糖等4条异常代谢通路,而这些异常途径反过来激发氧自由基生成增多,形成恶性循环,造成视网膜损害。对这个复杂的网络中线粒体超氧化作用和PARP异常激活等2个中心环节进行恰当的干预,可能是突破糖尿病视网膜病变治疗瓶颈最有前景的方法之一。

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
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