【Abstract】ObjectiveTo evaluate the localized biopsy of nonpalpable breast lesions (NPBLs) and its role in the early diagnosis and treatment of breast cancer. MethodsOne hundred and fifty-eight NPBLs from a series of 141 women detected by mammography were resected with wire localization technique. ResultsForty-two lesions (26.6%, 42/158) in 42 patients were diagnosed with malignant result, including 12(28.6%) patients with stage 0 breast cancer, 24(57.1%) with stageⅠ, 2(4.8%) with stage Ⅱ and 4(9.5%) with stage Ⅲ disease according to American Joint Committee on Cancer (AJCC) staging system（the 6th edition）. The contralateral axillary lymph nodes metastasis were found in only one (2.4%) patient with stage Ⅲ disease and the other fortyone patients remained free of recurrent disease at a median follow-up of 31 months.ConclusionThe results showed that the most nonpalpable breast cancers detected by mammography were earlystage breast cancers and had good prognosis. The NPBLs should get a localized biopsy in order to facilitate the early diagnosis and treatment of nonpalpable breast cancers.
目的探讨钼靶X线导丝定位切除触诊阴性乳腺病灶手术的临床应用价值。 方法对291例299个触诊阴性乳腺病灶在钼靶X线指引下经导丝定位并切除活检，确定病理类型。 结果299个触诊阴性乳腺病灶中乳腺癌病灶42个（14.05%），癌前病变40个（13.38%），良性病变257个（85.95%），其中乳腺癌灶多表现为簇状或弥漫细点状钙化，乳腺癌病灶中原位癌22个（52.38%，22/42），浸润癌Ⅰ期13个（30.95%，13/42），Ⅱ期4个（9.52%，4/42），Ⅲ期3个（7.15%，3/42）。40例乳腺癌患者（2例为双侧癌）均长期随访，最长随访时间为10年，复发转移2例。应用钼靶X线诊断乳腺癌的灵敏度为92.86%（39/42）；特异度为95.33%（245/257），诊断比值比（DOR）为265.42。 结论钼靶X线导丝定位病灶切除技术可提高触诊阴性乳腺病灶的早期诊断率，指导手术切除病灶，其组织损伤小，可靠性高，促进了乳腺癌二级预防，适合二级医院广泛应用。