Objective To investigate the characteristics of cognitive function and its correlation to neuroendocrine status in patients with refractory depression. Methods A total of 41 patients diagnosed by ICD-10 as depression onset who have been treated with more than two antidepressants drugs, fulfilled the criteria of refractory depression. Another 40 patients diagnosed by ICD-10 as depression onset but who have not been treated, or have been treated with only one antidepressant drug were selected as controls. Patients in both groups were evaluated by WAIS-RC, STROOP, VF, TRAILS A, B, TOH and M-WCST, and the concentrations of CORT, ACTH, T3, FT3, T4, FT4, TSH were also determined. Results A significant difference was found in VF between the refractory depression group and the control group. This showed that the damage to short-term memory, attention and interference rejection capability was much more serious in the refractory depression group. The ACTH concentration in the refractory depression group was significantly different from that of the control group, which indicated that the damage to the Hypothalamic-pituitary-adrenal axis was more serious in the refractory depression group. In particular in relation to memory and attention defect. Conclusion Changes in the levels of CORT, ACTH, TSH, FT3 and T4 may be correlated to cognitive function damage in patients with refractory depression.
Objective To investigate the cognitive functions in people at high risk for schizophrenia.Methods Two hundred and twenty-two people at high risk for schizophrenia and 331 normal controls were assessed with 14 neuropsychological tests. Results The results of some neuropsychological tests in people at high risk for schizophrenia were worse than those in the normal controls. These tests included information, arithmetic, digital symbol, block design, logical memory, visual memory, Stroop test, verbal fluency, tower of Hanoi, WCST and CPT (Plt;0.01). The time for trail making test A in was longer in the group at high risk for schizophrenia than in the control group (Plt;0.05).Conclusion People at high risk for schizophrenia have general cognitive deficits. Attention and executive function may represent the genetic endophenotype for schizophrenia.
Based on literatures on Meta-analysis and randomized controlled trial, drug use and some geriatrics syndromes such as cognitive impairment and depression, in elderly diabetic patients were reviewed. Insulin plus oral hypoglycemic drugs was more rational therapy for insulin resistance and islet dysfunction in type 2 diabetes mellitus. We should pay more attention to cognitive impairment and depression in elderly type 2 diabetic patients.
目的 探讨强迫症患者失匹配负波（MMN）的特征以及强迫症可能存在的认知功能障碍。 方法 2010年9月－2012年3月将符合纳入标准的21例强迫症患者（OCD）进行耶鲁-布朗强迫症状量表（Y-BOCS）评分，使用日本Nihon Kohden脑诱发电位仪，记录21例OCD患者、21例性别相匹配的正常对照组进行Cz导联MMN潜伏期以及波幅的测定，并将数据进行t检验、相关性分析等处理。 结果 强迫症与正常人组间比较存在MMN潜伏期（t=2.834，P=0.007）延长，波幅增高，但较正常对照组比较无统计学意义，MMN潜伏期与病程以及Y-BOCS评分无相关性。 结论 强迫症患者在大脑处理信息的早期阶段存在认知的自动加工功能的损害，与病程长短以及病情的严重程度无明显相关性。MMN是检测认知功能比较敏感的指标。