Congestive pulmonary arterial hypertension (PAH) is one of the most common complications of left to right shunt congenital heart disease. With the pulmonary artery pressure increasing, the shunt direction will reverse, eventually develop into Eisenmenger syndrome, and affect the patients' life. Studies in recent years have found that angiotensin -(1-7) and brain natriuretic peptide can adversely affect renin-angiotensin aldosterone system (RAAS), stromal cell derived factor can delay the pulmonary vascular remodeling, von Willebrand factor marks the pulmonary vascular endothelial function impaired, microRNA causes damage and homocysteine play a protective role in pulmonary vascular endothelial function. The RAAS activation, pulmonary vascular remodeling and endothelial dysfunction are related to the formation and development of PAH. We produced a comprehensive literature review about serological indexes in congestive PAH in this review.
目的探索食管癌、贲门癌、贲门失弛缓症术后胸腔感染的有效处理方法。 方法选取我院胸外科2012年1月至2014年6月间因食管癌、贲门癌、贲门失弛缓症手术并发食管胸腔瘘的患者42例，分为常规+臭氧治疗组和常规治疗组。常规治疗组28例，男22例、女6例，年龄54～78（63.5±6.8）岁，行胸腔闭式引流、抗感染、营养支持治疗；常规+臭氧治疗组14例，男11例、女3例，年龄39～74（64.7±9.1）岁，行常规治疗+臭氧胸腔保留灌注治疗。 结果两组年龄、性别、体重差异均无统计学意义（P＞0.05），常规+臭氧治疗组疗效明显优于常规治疗组：住院时间更短（P=0.017），住院费用更低（P=0.016），死亡率[0.00%（0/14）vs. 10.71%（3/28）]更低。 结论臭氧具有便捷、杀菌、消毒、不良反应以及促进脓腔吸收的作用，可以提高治疗效果，缩短住院时间，减少住院费用，值得临床推广和运用。