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find Author "贾维坤" 2 results
  • Expression Change and Its Implication of Cell Adhesion Molecules CD11b/CD18, sPselectin in Perioperative Period of Cardiopulmonary Bypass

    Abstract: Objective To observe the significance of the changes of cell adhesion molecules (CAM) CD11b/CD18 and sPselectin during the perioperative period of open heart surgery under cardiopulmonary bypass (CPB), and investigate the roles of CD11b/CD18 and sPselectin in systemic inflammatory response triggered by CPB. Methods Thirty patients including 18 males and 12 females, age ranged from 29 to 55 years (45.3±8.1 years) having undergone valvular replacement for rheumatic heart disease in our hospital were selected as the subjects of this research. After anesthesia induction, radial arterial blood sample was collected at six different time points including the time prior to skin incision, and 30 min, 1 h, 6 h, 12 h and 24 h following the start of CPB. The expression levels of CD11b/CD18 were tested by flow cytometry, and concentration of sP-selectin in the plasma was measured with enzymelinked immunosorbent assay(ELISA). Results The expression of CD11b/CD18 was elevated at 30min after CPB, and it reached the peak (581.44±215.26) at 6 h after CPB with significant differences (Plt;0.05). Its expression started to drop at 12 h after CPB, but it was still higher than the expression level before CPB. The expression returned under the level before CPB at 24 h after CPB with insignificance differences (Pgt;0.05). The expression of sPselectin in the peripheral blood started to rise evidently at 30 min after CPB, reaching the peak (51.44±10.06 ng/ml) with significant differences (Plt;0.05). Its expression level decreased at 12 h after CPB and fell back below the level before CPB with insignificant differences (Pgt;0.05). Conclusion CPB can cause the expression of CD11b/CD18 and sPselectin to rise in the peripheral blood, which may play an important role in the systemic inflammatory response triggered by CPB.

    Release date:2016-08-30 06:02 Export PDF Favorites Scan
  • 食管癌切除经食管床行弓上食管胃机械吻合术280例

    目的 总结使用弯管型吻合器经主动脉弓后食管床行食管胃吻合术的临床经验。方法 280例中、下段食管癌患者行食管癌切除、经弓后食管床行弓上食管胃机械吻合术,采用多次或一次性弯管型吻合器。结果 一次吻合成功278例,吻合失败2例,改为原位修补或弓旁手工吻合。全组患者均无吻合口出血。术后随访244例(87.1%),随访时间1~40个月。死亡3例,死亡原因:吻合口瘘、严重感染2例,心肌梗死1例。发生膈疝2例(合并胸胃穿孔1例),乳糜胸2例,经对症处理治愈;其余患者术后恢复良好。远期出现吻合口狭窄5例,均经沙氏扩张器扩张1~3次后缓解或治愈。结论 中、下段食管癌患者采用左胸后外侧肋间切口,使用弯管型吻合器经弓后食管床行食管胃弓上吻合,手术难度虽较大,对施术者的手术技术要求较高,但术后胃肠道重建符合正常消化道解剖结构,并发症较少,患者的生活质量得到提高。

    Release date:2016-08-30 06:26 Export PDF Favorites Scan
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