Objective Peri pheral nerve injury is a common cl inical disease, to study the effects of the physical therapy on the regeneration of the injured sciatic nerve, and provide a reference for cl inical treatment. Methods Sixty-four female adult Wistar rats (weighing 252-365 g) were chosen and randomly divided into 4 groups (n=16): group A, group B, groupC, and group D. The experimental model of sciatic nerve defect was establ ished by crushing the right sciatic nerve in groups B, C, and D; group A served as the control group without crushing. At 2 days after injury, no treatment was given in group B, electrical stimulation in group C, and combined physical therapies (decimeter and infrared ray) in group D. At 0, 7, 14, and 30 days after treatment, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MNCV) were measured, and morphological and transmission electron microscopy (TEM) examinations were done; at 30 days after treatment, the morphological evaluation analysis of axons was performed. Results At 0 and 7 days after treatment, the SFI values of groups B, C, and D were significantly higher than that of group A (P lt; 0.05); at 14 and 30 days after treatment, the SFI value of group D decreased significantly, no significant difference was observed between group D and group A (P gt; 0.05) at 30 days; whereas the SFI values of groups B and C decreased, showing significant difference when compared with the value of group A (P lt; 0.05). At 0, 7, and 14 days after treatment, the MNCV values of groups B, C, and D were significantly lower than that of group A (P lt; 0.05), and there were significantly differences between group B and groups C, D (P lt; 0.05); at 14 days, the MNCV value of group D was significantly higher than that of group C (P lt; 0.05); and at 30 days, the MNCV values of groups B and C were significantly lower than that of group A (P lt; 0.05), but there was no significant difference between group D and group A (P gt; 0.05). At 0 and 7 days, only collagen and l i pid were observed by TEM; at 14 and 30 days, many Schwann cells and perineurial cells in regeneration axon were observed in groups B, C, and D, especially in group D. Automated image analysis of axons showed that there was no significant difference in the number of myelinated nerve fibers, axon diameter, and myelin sheath thickness between group D and group A (P gt; 0.05), and the number of myelinated nerve fibers and axon diameter of group D were significantly higher than those of groups B and C (P lt; 0.05). Conclusion Physical therapy can improve the regeneration of the injured sciatic nerve of rats.
ObjectiveTo explore the risk factors of stroke-associated pneumonia in stroke inpatients at rehabilitation stage.MethodsA retrospective survey was conducted to collect the general clinical data of 271 patients with stroke who were hospitalized for the first time between January 2017 and December 2018. They were divided into two groups according to the presence or absence of pneumonia. The general clinical data of the two groups were observed and analyzed, including sex, age, length of stay, course of disease, Brunnstrom Stage, Barthel Index, scores of Kubota’s Water Drinking Test, indwelling gastric tube, cognitive impairment, aphasia, hypertension history, diabetes history, history of smoking and drinking, albumin content, and hemoglobin content. Statistically significant factors were screened out from single factor analysis, and then multivariate logistic regression analysis was conducted.ResultsThere were significant differences in age, length of stay, Barthel Index, Brunnstrom Stage (upper limb, hand and lower limb), scores of Kubota’s Water Drinking Test, indwelling gastric tube, albumin content, hemoglobin content, cognitive impairment, and aphasia between the two groups (P<0.05). Multivariate logistic regression analysis showed that indwelling gastric tube [odds ratio=52.463, 95% confidence interval (4.154, 662.658), P=0.002] was an independent risk factor for pneumonia.ConclusionsIndwelling gastric tube is an independent risk factor for pneumonia. In view of the risk factor, taking active and effective preventive measures can help prevent pneumonia.
Objective To investigate the etiological and clinical characteristics of the outbreak of hand-foot-mouth disease (HFMD) in Chengdu in 2008. Methods A retrospective analysis was conducted to investigate 482 children with hand-foot-mouth disease in Chengdu from January to December 2008 in terms of epidemiology and clinical characteristics. Results Among the 482 children, 76.14% of the cases were infants, and male children numbered more than female ones. The proportion in the urban area was higher than that in the rural area. May to July was the peak epidemic period. Skin rash and fever were major clinical manifestations. Three cases were diagnosed as viral encephalitis. Conclusion The incidence of hand-foot-mouth disease is related to age and season. Effective prevention measures and isolated treatment are critical for prevention and therapy.