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find Author "赵茹" 3 results
  • Research progress of β-adrenergic receptor antagonists in the treatment of ocular neovascular diseases

    Ocular neovascularization is a pathological change in various ocular diseases such as diabetic retinopathy, retinopathy of prematurity, central retinal vein occlusion and age-related macular degeneration, which seriously affects patient's vision. β receptors are expressed in conjunctiva, corneal epithelial cells, corneal endothelial cells, extraocular muscles, trabecular meshwork, ciliary muscle, lens and retina. β adrenergic receptor antagonists bind to β receptors to exert anti-angiogenic effects by inhibiting the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1, interleukin-6 and other angiogenic cytokines; reducing macrophage-related inflammatory response; increasing the expression of anti-angiogenic factors. In the treatment of corneal neovascularization, choroidal neovascularization, and retinopathy of prematurity, it can significantly reduce the area of neovascularization and delay disease progression. Co-administration of anti-VEGF drugs can reduce the frequency of administration of anti-VEGF drugs. At effective therapeutic concentrations, β-adrenergic receptor antagonists are well tolerated; they have broader targets than anti-VEGF drugs, which offers new treatment strategies for ocular neovascularization such as corneal, choroidal and retinal neovascularization.

    Release date:2022-05-18 04:03 Export PDF Favorites Scan
  • 纵形腹壁下动脉穿支皮瓣修复外阴肿瘤术后缺损创面

    目的 总结纵形腹壁下动脉穿支(deep inferior epigastric perforator,DIEP)皮瓣移位修复外阴肿瘤根治术后缺损创面的方法及疗效。 方法 2007 年8 月- 2009 年8 月,收治5 例57 ~ 68 岁女性外阴肿瘤患者。其中外阴鳞状细胞癌4 例,外阴黑色素瘤1 例。病程3 ~ 5 年。患者均行外阴广泛局部扩大切除术加腹股沟及盆腔淋巴结清扫,肿瘤切除后创面缺损范围为12 cm × 7 cm ~ 15 cm × 6 cm。采用大小为14 cm × 8 cm ~ 16 cm × 9 cm 的纵形DIEP 皮瓣移位修复创面。供区直接缝合。 结果 术后1 例皮瓣远端出现部分坏死,经换药后成活;其余4 例均顺利成活。创面Ⅰ期愈合4 例,Ⅱ期愈合1 例。供区切口均Ⅰ期愈合。术后4 例患者获随访,随访时间8 个月~ 2 年。1 例因外阴鳞状细胞癌复发后不能耐受再次手术而死亡;1 例外阴臃肿影响排尿,予皮瓣修整术后排尿恢复正常;余2 例外阴无臃肿,皮瓣色泽与下腹壁皮肤相似,质地柔软,无尿道口狭窄。供区腹壁无并发症发生。 结论 纵形DIEP 皮瓣移位是修复外阴肿瘤术后缺损创面的有效方法之一。

    Release date:2016-08-31 05:48 Export PDF Favorites Scan
  • Analysis of characteristics of bile cultures and types of bililary infections

    Objective To explore the pathogen distribution and the characteristics of antibiotics use of patients with positive bile culture in order to provide evidence for appropriate antibiotic use. Methods Using a patient-based approach, the clinical and laboratory data of patients with positive bile culture between December 1st 2016 and November 30th 2017 were retrospectively analyzed. The pathogen distribution and antibiotics use of patients with bililary duct infections and colonizations were analyzed. Multidrug-resistant organism infections of patients with bililary duct infections were studied. Results There were 299 submitted bililary samples and in which 158 were culture-positive (52.8%). One hundred and ten strains of pathogens were found in 79 patients with positive bile culture, including 66 strains of Gram-negative (G–) organisms (60.0%), 37 strains of Gram-positive (G+) organisms (33.6%), and 7 strains of fungi (6.4%). The top three G– organisms were Escherichia coli (25 strains, 22.7%), Klebsiella pneumoniae (9 strains, 8.2%), and Acinetobacter baumanii (7 strains, 6.4%). The top three G+ organisms were Enterococcus faecium (10 strains, 9.1%), Enterococcus faecalis (6 strains, 5.5%), and coagulase negativeStaphylococcus (6 strains, 5.5%). The number of patients with bililary duct infections and colonizations were 42 and 37, respectively, with pathogens occupied mainly by G– bacteria. Ten strains of multidrug-resistant organisms were isolated from patients with bililary duct infections. Compared to patients with non-multidrug-resistant organism infections, the length of antibiotics use was longer in patients with multidrug- resistant organism infections (t=2.129, P=0.039). The rate of target therapy for antibiotics in patients with bililary duct infections was 76.2%. The rate of proper antibiotics use was 16.2% before positive bile culture and 78.4% after positive bile culture in patients with bililary duct colonizations. Conclusions Pathogens isolated from bile culture of infection and colonization are predominantly G– organisms. The bile culture and blood culture should be done for patients with suspected bililary duct infection. Infection and colonization should be distinguished for positive bile culture and antibiotic should be chosen according to drug susceptibility test results.

    Release date:2018-03-26 03:32 Export PDF Favorites Scan
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