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find Author "邬云红" 3 results
  • A Study on the Levels of Glucagon-like Peptide-1 and Glucose-dependent Insulinotropic Polypeptide in People with Different Glucose Tolerance Degrees

    【摘要】 目的 了解不同糖代谢状态的人群空腹及口服葡萄糖耐量实验(oral glucose tolerance test,OGTT)餐后胰高血糖素样态-1(GLP-1)和葡萄糖依赖的促胰岛素多态(GIP)水平。 方法 将受试者根据OGTT结果分为3组:正常糖耐量组(NGT,n=61例),糖耐量受损组(IGT,n=53)和2型糖尿病组(T2DM, n=66)。采空腹及糖餐后2 h静脉血检测GLP-1和GIP水平。 结果 T2DM组空腹GLP-1水平低于NGT和IGT组(Plt;0.05)。NGT和IGT的空腹GLP-1水平差异无统计学意义(Pgt;0.05)。餐后GLP-1水平三组差异无统计学意义(Pgt;0.05)。空腹及餐后GIP水平在NGT、IGT和T2DM均呈逐渐增加的趋势,而且同OGTT-0 h和OGTT-2 h血糖水平呈正相关(r=0.384,0.426;Plt;0.05)。 结论 不同的GLP-1和GIP水平也许是IGT和T2DM胰岛素分泌能力不同的原因之一。【Abstract】 Objective To investigate the fasting, and after oral glucose tolerance test (OGTT), the postprandial levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in Chinese people with different degrees of glucose tolerance. Methods Based on the results of OGTT, 180 subjects were divided into three groups: normal glucose tolerance group (NGT group, n=61), impaired glucose tolerance group (IGT group, n=53) and type-2 diabetes mellitus group (T2DM group, n=66). Fasting venous blood and the venous blood 2 hours after OGTT was sampled to detect GLP-1 and GIP levels. Results The fasting GLP-1 level in the T2DM group was significantly lower than that in the NGT and IGT groups (Plt;0.05). There was no significant difference in fasting GLP-1 level between NGT and IGT groups (Pgt;0.05). There was no significant difference in GLP-1 level 2 hours after OGTT among all the three groups (Pgt;0.05). GIP level gradually increased in the order of NGT, IGT and T2DM both before and after glucose load, and it was positively correlated with glucose levels just after OGTT and 2 hours after OGTT (r=0.384,0.426;Plt;0.05). Conclusion Different GLP-1 and GIP levels may be one of the reasons for different insulin secretion ability between IGT and T2DM

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 高原人群糖化血红蛋白的研究进展

    在多项血糖监测的指标中,糖化血红蛋白(hemoglobin A1c,HbA1c)目前是在评价血糖管理、治疗方案有效性及防控糖尿病并发症中运用最广泛且最重要的指标。然而高原低氧、低气压及民族等因素对 HbA1c 水平影响的结论仍存在争议,该文就高原环境及民族差异对 HbA1c 的具体影响及可能的机制进行了综述。

    Release date:2017-12-25 06:02 Export PDF Favorites Scan
  • Relationship of the blood pressure, glucose, and lipid with obesity in adult Tibetans in urban area of Xigaze in Tibet

    Objective To explore the relationship between obesity and the three targets including blood pressure, glucose, and lipid. Methods A total of 181 adult Tibetans who underwent physical examination between March and September 2015 at Xigaze People's Hospital were enrolled in this study. Their obesity degrees were assessed with body mass index (BMI) and waist circumference (WC) respectively. The levels of blood pressure, glucose, and lipid were compared at the different levels of BMI or WC. Results The incidence of systematic obesity and central obesity in these adults were 57.5% and 79.0%, respectively. Compared the overweight group with the normal BMI group, the systolic pressure and diastolic pressure of the former were 9.26 mm Hg (1 mm Hg=0.133 kPa) [95% confidence interval (CI) (3.46, 15.07) mm Hg, P=0.002] and 7.76 mm Hg [95%CI (3.96, 11.57) mm Hg, P<0.001] higher, respectively. Similarly, the systolic pressure and diastolic pressure of the central obesity group were 8.24 mm Hg [95%CI (1.03, 15.46) mm Hg,P=0.026] and 6.79 mm Hg [95%CI (2.03, 11.55) mm Hg, P=0.006] higher than those in the normal WC group, respectively. For the normal WC or normal BMI subjects, the detection rate of dyslipidemia reached up to 50.0% and 52.6%. Conclusions With the increase of BMI/WC values, the level of blood pressure rises. Even though WC or BMI is normal, the detection rate of dyslipidemia is high.

    Release date:2018-05-24 02:12 Export PDF Favorites Scan
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