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find Author "邱有波" 3 results
  • Integrated Treatment of Chinese Medicine plus Western Medicine for Dysfunctional Uterine Bleeding: A Meta-Analysis

    Objective To conduct Meta-analyses on published literatures about the Jianpi Bushen Decoction combined with western medicine for dysfunctional uterine bleeding (DUB), so as to evaluate its efficacy and safety compared with the western medicine treatment. Methods The following databases such as PubMed (1995 to 2011), EMCC (1995 to 2011), CBM (1995 to 2011), CNKI (1995 to 2011), Wanfang (1989 to 2011) and VIP (1989 to 2011) were searched to collect the randomized controlled trials (RCTs) on Jianpi Bushen Decoction combined with western medicine for DUB. The selection of studies, assessment of methodological quality and data extraction were performed independently by two reviewers according to the Cochrane systematic review methods, and Meta-analyses were performed by using RevMan5.0 software. Results A total of 12 RCTs involving 925 cases were included, of which 471 ones were in the experimental group while the other 454 ones were in the control group. Each study was comparable in baseline data, all with reporting of using random methods, but no mention of detailed random methods, blind methods and allocation concealment. The results of Meta-analyses indicated that compared with single therapy of western medicine, Jianpi Bushen Decoction combined with western medicine for DUB was superior in the total effective rate (OR=5.60, 95%CI 3.25 to 9.67, Plt;0.000 01), bleeding recovery rate (OR=3.79, 95%CI 2.70 to 5.32, Plt;0.000 01), and bleeding recurrence rate (OR=0.14, 95%CI 0.05 to 0.42, P=0.000 5), with significant differences. Conclusions The integrated treatment of Jianpi Bushen Decoction and western medicine has certain effects on dysfunctional uterine bleeding, and it may be a promising treatment option. Due to the poor quality and high possibility of bias of the included studies, more well-designed multi-centered RCTs should be performed.

    Release date:2016-08-25 02:39 Export PDF Favorites Scan
  • Sodium Ozagrel Combined with Edaravone for Cerebral Infarction: A Systematic Review

    Objective To assess the effectiveness and safety of sodium ozagrel combined with edaravone for cerebral infarction. Methods Such databases as PubMed (1995 to 2010), EMCC (1995 to 2010), CBM (1995 to 2010), CNKI (1995 to 2010), and VIP (1989 to 2010) were searched to collect randomized controlled trials (RCTs) of odium ozagrel combined with edaravone for cerebral infarction. Then the retrieved studies were screened according to the predefined inclusion and exclusion criteria, the data were extracted, the quality of the included studies was evaluated, and meta-analyses were performed by using the Cochrane Collaboration’s RevMan 5.0 software. Results A total of 32 RCTs involving 3 059 cases were involved, among which 1 559 cases were in the treatment group and the other 1500 were in the control group. All studies with comparable baseline data reported the application of random methods without explaining the detailed methods, the blinding method and the allocation concealment. The results of meta-analyses indicated that sodium ozagrel combined with edaravone had significant differences in the effective rate for cerebral infarction compared with both single sodium ozagrel (OR=3.51, 95%CI 2.70 to 4.57) and routine treatment (OR=3.77, 95%CI 2.58 to 5.52), and it had significant differences in treating the defect of neurological function compared with both sodium ozagrel (WMD= –4.26, 95%CI –4.97 to –3.55) and routine treatment (WMD= –3.89, 95%CI –4.96 to –2.82). In addition, Sodium ozagrel combined with edaravone was superior to sodium ozagrel (WMD=13.57, 95%CI 9.84 to 17.30) in improving the ability of daily living. Conclusion This systematic review shows that sodium ozagrel combined with edaravone is quite effective in treating cerebral infarction, and it can improve the nerve dysfunction. This conclusion should be treated cautiously for the poor quality and higher possibility of bias in the included studies which may impact on the power of proof, so more double-blind RCTs with high quality are expected to provide high-quality evidence.

    Release date:2016-09-07 11:06 Export PDF Favorites Scan
  • 双歧杆菌乳杆菌三联活菌片对小儿化脓性扁桃体炎抗生素相关性腹泻的预防效果观察

    目的探讨双歧杆菌乳杆菌三联活菌片预防小儿化脓性扁桃体炎抗生素相关性腹泻(ADD)的临床疗效。 方法选取2013年1月-2014年7月儿科住院诊断为化脓性扁桃体炎患儿300例,按入院先后顺序,采用随机数字表法分为对照组和干预组各150例,对照组常规给予抗生素和对症治疗;干预组在对照组常规治疗的基础上,给予双歧杆菌乳杆菌三联活菌片口服预防治疗,比较两组患儿住院期间ADD发生率。 结果干预组13例患儿发生ADD,发生率为8.67%;对照组29例患儿发生ADD,发生率为19.33%。干预组ADD发生率低于对照组,差异有统计学意义(χ2=7.087,P=0.008)。 结论双歧杆菌乳杆菌三联活菌片辅助治疗小儿化脓性扁桃体炎可预防抗生素治疗后引起的不良作用,提高患儿机体的免疫力,降低ADD的发生率。

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