目的 探讨腹腔镜术中联合结肠镜治疗结直肠小占位病变的可行性和临床应用价值。方法对我院2006年12月至2009年5月期间23例行腹腔镜联合结肠镜手术的结直肠小占位病变患者的临床资料进行回顾性分析。结果 所有患者均在腹腔镜下完成手术，无中转开腹。 手术时间80～200 min，平均140 min; 出血80~120 ml，平均100 ml。 9例息肉病变行局灶切除，术中经快速冰冻切片病理证实4例早期癌及10例不典型增生均行相应肠段切除。 术后1例出现轻度肺炎，经积极抗炎对症治疗后痊愈，其余患者恢复良好。 所有患者术后第1天即离床活动，住院时间5～10 d，平均7 d。结论 腹腔镜术中联合结肠镜治疗结直肠占位是安全可行的，有助于结直肠病灶及切缘的准确定位，可缩短手术时间，值得临床进一步推广应用。
Objective To investigate the possibility of laparoscopic cholecystectomy （LC） on porcelain gallbladder. Methods Twenty-four cases of porcelain gallbladder， who were operated in China Medical University， including 13 LC cases， from 2006 to 2008 were retrospectively reviewed. Results Of 24 porcelain gallbladder cases (0.48%) in 4964 cholecystectomy patients， calcification of gallbladder in 87.50%(21/24) patients was diagnosed by ultrasonography. Of 13 patients who were cured by LC, one suffered from postoperative leak bile, no metastasis were found by following up 12 or 14 months in two gallbladder carcinoma cases. Conclusion There’s specificity of ultrasonographic image in porcelain gallbladder, in which LC is safe to be performed and routine frozen pathology during operation is necessary.
ObjectiveTo explore the influence factors of gallstone. MethodsClinical data of 511 patients who were admitted to our hospital from Apr. 2015 to Apr. 2016 were retrospectively analyzed. ResultsOf 511 patients, there were 274 patients with gallstone (gallstone group) and 237 patients without gallstone (control group). Univariate analysis results showed that, no significant difference of age, gender, and diabetes was found between gallstone group and control group (P > 0.050), but the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), and fasting blood glucose (FBG) were significantly higher in patients of gallstone group (P < 0.050), but the level of serum high density lipoprotein (HDL-C) was significantly lower in patients of gallstone group (P=0.001). Logistic regression results showed that four factors including diabetes〔OR=4.491; 95% CI is (2.021, 9.976); P < 0.001〕, the serum TC〔OR=2.548; 95% CI is (1.944, 3.338); P < 0.001〕, HDL-C〔OR=0.115; 95% CI is (0.056, 0.237); P < 0.001〕, and FBG〔OR=1.277; 95% CI is (1.086, 1.502); P=0.003〕 entered the final regression model after controlling confounding factors. The results showed that patients who combined with diabetes, high levels of serum TC and FBG, and low level of serum HDL-C, had higher ratio of galls-tone. ConclusionDiabetes, high-level of serum TC and FBG, low-level of serum HDL-C were risk factors of gallstone.
Objective To investigate the effects of hand assistant laporoscopic splenectomy plus pericardial devascularization on systemic stress responses. Methods Forty patients with cirrhotic portal hypertension were selected， 20 cases of which were underwent hand assistant laparoscopic splenectomy plus pericardial devascularization (LAP group)， and the other 20 were underwent open splenectomy plus pericardial devascularization (OP group). The levels of blood glucose （BG）, insulin (Ins), triiodothyronine （T3）, tetraiodothyronine （T4）, corticosteroid （CS） and other related clinical data were measured before operation and on day 1-3 after operation, which were compared between two groups. Results There was no statistical significance between two groups on those levels before operation. On day 1 after operation， BG and CS level in both two groups were higher than those before operation (P＜0.05), but they were recovered on day 2 after operation in LAP group (Pgt;0.05), and on day 3 after operation in OP group (Pgt;0.05). BG and CS level in OP group were markedly higher than those in LAP group on day 2 after operation (P＜0.05). On day 1 after operation， Ins, T3 and T4 level of two groups were lower than those before operation (P＜0.05), but they were recovered on day 2 after operation in LAP group (Pgt;0.05) and on day 3 after operation in OP group (Pgt;0.05). Ins, T3 and T4 level in OP group were lower than those in LAP group on day 2 after operation (P＜0.05). There was no significant difference in operation time between two groups (Pgt;0.05). But laparoscopic surgery had more advantages than conventional open surgery such as reducing bleeding quantity in operation, shortening recovery time of bowel and urinary bladder function and the length of stay. Conclusion Compared with laparotomy, the laparoscope not only imposes less impact on physical stress system, but also makes recovery after operation more quickly.
目的探讨超声引导下经皮经肝胆囊穿刺引流术（PTGD）联合二期腹腔镜胆囊切除术（LC）治疗急性胆囊炎的安全性和可行性。 方法回顾性分析我院2008年7月至2013年7月期间对急性胆囊炎先行PTGD后二期LC的117例患者的临床资料。 结果本组117患者PTGD术后均成功实施二期LC，PTGD术顺利，无并发症发生，PTGD管平均留置时间27.4 d（21～31 d）。LC采用单孔法33例，三孔法84例，全部病例均治愈。手术平均时间为48.5 min（32～92 min），腹腔引流管拔除平均时间为2.3 d（2～4 d）。无中转开腹者，无胆管损伤、出血、胆汁漏等并发症发生。病理结果为急性胆囊炎。本组随访患者无术后并发症。 结论超声引导下PTGD联合二期LC治疗急性胆囊炎安全、有效。
目的 总结经脐单切口腹腔镜阑尾切除术的技术要点。方法 回顾性分析2012年1月至12月期间中国医科大学附属第四医院收治并行经脐单切口腹腔镜阑尾切除术的55例阑尾炎患者的临床资料。结果 54例患者手术均获成功，1例患者因腹膜后阑尾而中转为3孔法。手术时间为（40.6±12.3） min （35～90min），住院时间为（4.5±1.3） d （3～6d），住院费用为（1.2±0.3）万元（0.8～1.5万元），术后均无并发症发生。术后49例患者获访，随访时间为1～6个月，平均4.8个月。术后患者均恢复良好，脐部瘢痕不明显，美容效果较满意。结论 采用通用器械行经脐单切口腹腔镜阑尾切除术安全、可行，美容效果较佳。
目的 探讨自制双套管持续冲洗负压引流治疗胰腺术后胰瘘的效果。 方法 回顾性分析2008 年 8 月至2014 年3 月期间于笔者所在医院接受自制双套管持续冲洗负压引流治疗的12 例胰瘘患者的临床资料，总 结效果。 结果 12 例患者均接受双套管持续冲洗负压引流治疗，治疗期间引流管若有堵塞，可拔出体外清理。所 有患者均于拔管后治愈。更换双套管早期（1 ～ 3 d）患者发热等感染症状明显缓解，引流10 ～ 22 d 后引流量逐渐 减少。出院后所有患者均获访6 个月，患者恢复良好，胰瘘部位包裹吸收，无并发症发生。 结论 自制双套管持续 冲洗负压引流治疗胰腺术后胰瘘的效果满意，安全可行。
Objective The aim of this research was to explore the relationship between type D personality and symptom duration/emergency admissions/mental health status/quality of life (QOL) in Chinese rectal cancer patients. Methods Rectal cancer patients who were treated in our hospital form Oct. 2010 to Oct. 2012 were selected prospectively, and then their type D personality was measured with the 14-item Type D Personality Scale (DS14). Mental health status was measured with the Hospital Anxiety and Depression Scale (HADS). The QOL was assessed longitudinally by using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-CR38 questionnaires at the baseline and 6 months after diagnosis. Comparison between the type D personality group and non-type D personality group in social-demographic characteristics, clinicopathological features, mental health status, and QOL was performed. Results Of the 596 patients (92%) who responded, 131 patients (22%) had type D personality. ① Compared with non-type D personality group, the proportions of patients with duration of symptoms ≥1 month, without medical insurance, and emergency admissions in type D personality group were all higher, as well as the poor economic situation and more complication ( P<0.050). ② EORTC QLQ-C30. At the baseline, scores of role function, emotional function, cognitive function, social function, and overall health status in type D personality group were all lower than those of non-type D personality group ( P<0.050), but scores of fatigue, constipation, and financial difficulties in type D personality group were all higher than those of non-type D personality group ( P<0.050). In 6 months after diagnosis, scores of role function, emotional function, cognitive function, social function, and overall health status in type D personality group were all lower than those of non-type D personality group ( P<0.050), but scores of fatigue, insomnia, constipation, and financial difficulties in type D personality group were all higher than those of non-type D personality group ( P<0.050). ③ EORTC QLQ-CR38. At the baseline, score of expectation for the future in type D personality group was lower than that of non-type D personality group ( P<0.001), but score of urinary problems in type D personality group was higher in type D personality group than that of non-type D personality group ( P<0.001). In 6 months after diagnosis, scores of expectation for the future and sexual function in type D personality group were both lower than those of non-type D personality group ( P<0.050), but scores of urinary problems, gastrointestinal symptoms, male sexual dysfunction, and excretion difficulties in type D personality group were all higher than those of non-type D personality group ( P<0.050). ④ At the baseline and 6 months after diagnosis, the incidences of anxiety and depression in type D personality group were all higher than those of non-type D personality group at the same time point ( P<0.001). In type D personality group, the incidences of anxiety and depression in 6 months after diagnosis were both higher than baseline ( P<0.001). Conclusion Type D personality may be a general vulnerability factor to screen for subgroups at risk for longer SD and emergency admissions in clinical practice of rectal cancer patients, and it was associated with poor QOL and poor mental health status.
ObjectiveTo investigate the proportion of peripheral blood CD4+CD25+ regulatory T cells (Tregs) in patients with pancreatic head carcinoma, the dynamic changes of these cells before and after pancreatoduodenectomy were also analyzed. MethodsThe proportions of peripheral blood CD4+CD25+ Tregs in patients with pancreatic head carcinoma and normal individuals were examined by using flow cytometric analysis. The CD4+/CD8+ ratio was also studied before and after operation. ResultsThe patients with pancreatic head carcinoma showed higher ratio of CD4+CD25+ and CD4+CD25high Tregs compared with normal control before operation (Plt;0.05). However, the percentage of these T cells reduced significantly after pancreatoduodenectomy, which was most obviously on the 3rd day after operation (Plt;0.01, Plt;0.05). After operation, CA199 level began to decrease, which was obvious on the fourteen day after operation. This tendency of CD4+CD25high Tregs changes was similar to that of CA199. The patients showed an decreased ratios of CD4+/CD8+ compared with normal controls, which further declined after operation, and reached the lowest point on the seventh day after operation (Plt;0.05). ConclusionsPancreatoduodenectomy may be helpful for the recovery of antitumor immunity. The perioperative period of patients with pancreatic head carcinoma may be a beneficial windowphase for immune intervention and Tregs may be served as target cells.