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find Author "钟琳" 2 results
  • 重症肌无力患儿呼吸道感染临床分析

    目的探讨重症肌无力(MG)患儿合并的呼吸道感染的临床特征及防治对策。 方法分析2005年4月-2015年11月合并呼吸道感染的22例住院MG患儿的临床资料,总结其呼吸道感染的类型、病原菌及治疗情况,分析影响呼吸道感染的因素。 结果MG患儿以下呼吸道感染为主,占68.2%(15/22);病原菌检出率为36.4%(4/11),86.4%(19/22)的患儿接受了抗生素治疗,其中14例为一联抗生素治疗;下呼吸道感染的MG患儿较上呼吸道感染者有咳嗽无力表现的比例更高,差异有统计学意义(P<0.05);有吞咽困难表现及使用激素对MG患儿上下呼吸道感染的发生无显著影响。 结论MG患儿合并呼吸道感染时多累及下呼吸道,尤其是有咳嗽无力表现者,大部分需要抗生素治疗;应早期识别该类患儿的临床特征,及时给予正确处理。

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  • PERCUTANEOUS PENETRATION ABILITY OF DEXAMETHASONE-AMLODIPINE BESYLATE COMPOUND GEL AND ITS EFFECT ON SURVIVAL OF ISCHEMIC RANDOM SKIN FLAP

    Objective Dexamethasone (DXM) can regulate the balance of neutrophil and cytokine and enhance the ischemia-reperfusion tolerance of the skin flap; amlodipine besylate (AB) can selectively expand the peripheral blood vesselsand rel ieve the vascular smooth muscle spasm. To investigate the percutaneous penetration abil ity of DXM/AB compound gel and evaluate its effect on survival of ischemic skin flap. Methods Sodium carboxymethylcellulose was used to make blank gel, which was mixed in DXM, AB, azone (AZ), and progylene glycol (PG) respectively to make the compound gel containing 0.3%DXM/0.5%AB only (group D), the compound gel containing 3%AZ/2%PG, 3%AZ, and 2%PG (groups A, B, and C), the 0.3%DXM gel containing 3%AZ/2%PG (group E), the 0.5%AB gel containing 3%AZ/2%PG (group F). The accumulative penetration of DXM and AB in compound gel, 0.3%DXM gel, 0.5%AB gel through excised rat skin and its penetration within flap tissue were investigated by ultraviolet spectrophotometry. Fifty SD rats were selected to make 100 mm × 10 mm random flap at the back, and were randomly divided into 5 groups according to different gels which were used to treat flaps (n=10): compound gel group (group A1), 0.3%DXM gel group (group B1), 0.5%AB gel group (group C1), blank gel group (group D1), and peritoneal injection of DXM (5 mg/kg) and AB (2 mg/kg) (group E1). The survival area of ischemic random skin flap was measured on the 7th day by planimetry. Twenty-four SD rats were selected to make 100 mm × 10 mm random flap at the back, and were randomly divided into 2 groups (n=12). The accumulative penetration of DXM and AB within skin flap were also detected at 2 and 6 hours after appl ication of 2 g of compound gel containing 3%AZ/2%PG (group A2) and peritoneal injection AB (2 mg/kg) / DXM (5 mg/kg) (group B2). Results The accumulative penetration of DXM and AB in compound gel were increased in time-dependent manner (P lt; 0.05), and it was the highest in group A, and was significantly higher than that in group B and group C (P lt; 0.01), but there was no significant difference when compared with group E or group F (P gt; 0.05). The accumulative penetration of DXM and AB in groups A, B, and C were significant higher than that in group D (P lt; 0.05). After 7 days, the survival area of flaps in groups A1, B1, C1, D1, and E1 were (695.0 ± 4.6), (439.3 ± 7.1), (477.5 ± 14.5), (215.2 ± 3.8), and (569.4 ± 9.7) mm2, respectively; group A1 was significantly higher than other groups (P lt; 0.05). After 2 and 6 hours, the quantities of DXM and AB in skin flap of group A2 were significantly higher than that of group B2 (P lt; 0.05). Conclusion In 0.3%DXM/0.5%AB compound gel, DXM and AB might penetrate into skin tissue, which could significantly increase the survivalarea of ischemic skin flap.

    Release date:2016-08-31 05:48 Export PDF Favorites Scan
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