目的:观察苯那普利联合银杏达莫注射液对糖尿病肾病(DN)患者蛋白尿、肾功能以及血液流变学指标的影响。方法:75例2型糖尿病肾病患者随机分为对照组和治疗组,对照组给予饮食控制、降糖、降脂等常规治疗,对照组在常规治疗基础上给与苯那普利和银杏达莫注射液治疗,疗程共12周,分别观察治疗前后两组患者空腹血糖、血脂和肾功能以及UAER和血液流变学参数的变化。结果:治疗12周后,两组患者空腹血糖控制良好,治疗组患者UAER较对照组明显下降,分别为314.62±49.83 mL/min和282.97±36.62 mL/min,治疗组患者肾功能和血液流变学参数较治疗前明显改善(Plt;0.05)。结论:苯那普利联合银杏达莫注射液能明显改善糖尿病肾病患者血液流变学参数,提高肾脏功能,减少24 h尿蛋白。
ObjectiveTo evaluate the effects and safety of ginkgo leaf extract and dipyridamole combined with betahistine injection for the treatment of vertebrobasilar ischemia with vertigo. MethodsThe Cochrane Library, Medline, Embase, Web of Science, China National Knowledge Infrastructure, VIP Database, Wanfang Database and China Biology Medicine Databases were searched from their establishment to September 2015. We used the method recommended by the Cochrane collaboration to perform a meta-analysis on randomized controlled trails. ResultsSix studies were included. The results of meta-analysis demonstrated that ginkgo leaf extract and dipyridamole combined with betahistine injection for the treatment of vertebrobasilar ischemia with vertigo was superior to either ginkgo leaf extract and dipyridamole or betahistine injection in total effective rate[RR=1.21, 95%CI (1.08, 1.35), P=0.000 7; RR=1.17, 95%CI (1.05, 1.31), P=0.006]. ConclusionGinkgo leaf extract and dipyridamole combined with betahistine injection is effective for the treatment of vertebrobasilar ischemia with vertigo. However, due to the limited quantity and quality of the included studies, the results need to be further confirmed.