ObjectiveTo study the effectiveness and safety of glucosamine for osteoarthritis (OA) in Asian population. MethodDatabases of PubMed, Embase, CNKI, VIP and Wanfang were searched from the time of establishment till May 2014 and controlled trials of glucosamine compared with placebo or nonsteroidal anti-inflammatory drugs (NSAIDs) were included. Quality evaluation and Meta-analysis by using RevMan 5.1 were performed. ResultsA total of 17 studies including 2 251 cases were included. The efficiency rate in the glucosamine group was higher than that in the NSAIDs group[OR=3.03, 95% CI (1.78, 5.18), P<0.000 1]. The efficiency rate in the glucosamine combined NSAIDs group was higher than that in the NSAIDs group[OR=4.30,95%CI (1.84,10.06),P=0.000 8]. The safety analysis showed that the adverse event rate in the glucosamine group was lower than that in the NSAIDs group[OR=0.23,95%CI (0.14,0.37),P<0.000 01], while the difference between the glucosamine combined NSAIDs group and the NSAIDs group was not statistically significant[OR=0.84, 95%CI (0.50, 1.41), P=0.50]. ConclusionsCompared with NSAIDs, glucosamine is better and safer for OA treatment in Asian population.
目的 探讨绝经后健康女性的稳定极限范围（LOS）与育龄期健康成年女性相比有无下降，了解绝经后女性是否开始出现LOS的下降。 方法 选取2012年1月－10月期间于四川大学华西医院健康体检的女性共40例，绝经组：20例绝经后健康女性，年龄（56.2 ± 3.3）岁；对照组：20名育龄期健康女性，年龄（24.3 ± 3.5）岁。对所有受试者分别使用压力平板仪测定前后左右4个方向LOS，使用SPSS 17.0统计学软件比较两组LOS的差异性。 结果 前、后、左、右4个方向的LOS在绝经组与对照组之间差异无统计学意义（P＞0.05）。绝经组及对照组的左右侧LOS大于前后侧、前侧LOS大于后侧，差异具有统计学意义（P＜0.05）；左右侧LOS差异无统计学意义（P＞0.05）。 结论 绝经后女性仍保持较好的LOS，提示其仍具备良好的主动姿势控制能力。