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find Author "陈叶红" 6 results
  • The clinical features and Video-EEG of Eyelid myoclonia-nonconvulsive status epilepticus in children

    ObjectiveTo study the clinical and EEG features, therapeutic response and prognosis of eyelid myoclonia-nonconvulsive status epilepticus (EM-NCSE) in children.MethodsCollected the clinical and EEG data of 3 children with EM-NCSE that were diagnosed in department of neurology in Qilu Children Hospital of Shandong university during the January in 2015 to August in 2016.Analysed the therapeutic response to antiepletic drugs(AEDs).ResultsAmong the three children, there were 2 girls and 1 boy.The age at the onset of the disease was from 6 to 10 years old.The average age of them is 8.67 years old.The clinical manifestations include mental confusion, dysphoria, winking and scrolling up the eyes.The typical vedio electroencephalography (VEEG) in the patients showed 3~6 Hz generalized spike and waves and polyspikes burst, especially in the frontal and the anterior temporal region.In addition, the eye closure and intermittent photic stimulation helped to induce discharges and clinical events as eyelid myoclonia (EM).ConclusionsEM-NCSE is one of the idiopathic and generalized epileptic disease and characterized by EM.Video EEG monitoring plays an important role in the diagnosis of this disease.The drugs of choice for treatment was diazepam.When the event was controlled, AEDs were effective for the following therapy.

    Release date:2017-05-24 05:46 Export PDF Favorites Scan
  • 儿童癫痫综合征遗传研究进展

    癫痫是一种多基因遗传的复杂疾病,其表型特征涉及多个基因序列和表达的改变,目前已明确与人类癫痫相关的基因有500多个,所涉及的癫痫种类众多,表型各异。新一代测序技术极大地增加了新的癫痫致病基因的发现速度,使临床能够确定越来越多患者的癫痫遗传病因,并更好地理解该疾病潜在的病理生理机制。儿童癫痫综合征具有特殊的临床及电生理特征,常具有明显的遗传背景,特定年龄段起病,因此在癫痫相关遗传研究中也有着最为丰硕的收获。文章就遗传性全面强直-阵挛发作性癫痫、全面性癫痫伴热性惊厥附加症、儿童失神癫痫、青少年肌阵挛癫痫等儿童癫痫综合征相关的致病基因,特别是电压门控离子通道的亚基,以及配体门控离子通道的亚基等最新研究进展进行总结。

    Release date:2017-09-26 05:09 Export PDF Favorites Scan
  • A case of Aicardi-Goutières syndrome

    ObjectiveAicardi and Goutières syndrome was first reported as a rare hereditary encephalopathy with white matter involvement in 1984. Typical clinical manifestations include severe mental motor development retardation or regression, pyramidal and extrapyramidal symptoms and signs, epilepsy, microcephaly and frostbite.MethodsTo collect a case of patient who presented with convulsions 14 days after birth without obvious inducement. The child was diagnosed as epilepsy in the local hospital and the symptoms improved after treatment with antiepileptic drugs. At 4 months, the child presented nods and clenched fists, and was diagnosed as infantile spasm. After Adrenocorticotrophic hormone and drug treatment, the symptoms gradually improved. Due to upper respiratory track infection, the child was aggravated at the age of 1 year and 2 months, and then diagnosed as Aicardi-Goutières syndrome by video EEG, skull MRI, fundus and gene screening.ResultsSurgery and treatment with antiepileptic drugs significantly improved the symptoms of the child, and the pathological biopsy of the brain tissue supported the previous diagnosis.ConclusionsThe report of this case will help to improve the clinician's diagnosis and treatment of Aicardi-Goutières syndrome.

    Release date:2019-03-21 11:04 Export PDF Favorites Scan
  • A case report and literature review on the combination of catarrh with infantile spasm

    ObjectiveTo explore the clinical manifestation, diagnosis, treatment and prognosis of infantile spasm complicated with craniostenosis.MethodsA case of infantile spasm complicated with craniostenosis in the Department of Neurology of Qilu Children's Hospital in December 2017 was reviewed with the literature. The clinical manifestations, diagnosis, treatment and prognosis of infantile spasm with craniostenosis were analyzed.ResultsThe proband infantile spasms and craniostenosis was diagnosed by clinical, imaging examination and VEEG. Epileptic attack was prevented and craniostenosis was corrected by hormone shock therapy (corticotrophin was administered for 14 days, followed by topiramate)and surgical treatment (cranial cap reconstruction was performed), and good clinical prognosis was obtained.ConclusionThis case was the first reported case of craniostenosis with infantile spasm in China, and compared with the foreign treatment method, better treatment method and the operation opportunity were obtained. Which has a significant effect on the clinical treatment of infantile spasm complicated with transcranial disease.

    Release date:2020-07-20 08:13 Export PDF Favorites Scan
  • 互联网医疗在癫痫患儿中的临床价值探讨

    通过对山东大学附属儿童医院癫痫中心远程会诊中心三级诊疗服务体系的应用情况进行总结、分析,探讨互联网医疗在癫痫患儿诊治及管理中的应用价值。利用癫痫与脑电远程会诊云平台为核心,上联三级癫痫中心,下联基层医疗机构,促进对各级癫痫中心脑电图检查项目技术操作及报告的同质化管理,实现跨区域脑电诊断中心专家资源的共享,促进优质医疗资源的输出,有助于患者得到更快速、准确的诊疗,通过互动交流帮助基层医疗机构全面性提高癫痫诊治能力。

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  • 基于山东省脑电图医疗质量控制体系的初步建设与实践

    近年来,随着神经电生理专业的飞速发展,脑电图监测技术在国内医疗机构的应用越来越普遍,但在脑电图专业突飞猛进的同时也暴露了部分脑电图监测单元脑电图像记录质量欠佳、诱发实验不规范、诊断术语不统一的现象时有发生,因此脑电图技术医疗质量控制体系的建设迫在眉睫。本文以山东大学附属儿童医院癫痫中心的质控管理工作为例,初步探讨山东省脑电图技术的质控体系建设与实践效果分析。

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