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find Author "陈敏" 55 results
  • Testing Treatments—Better Research for Better Healthcare

    Release date:2016-08-25 03:35 Export PDF Favorites Scan
  • Testing Treatments –– Better Research for Better Healthcare

    Release date:2016-08-25 03:36 Export PDF Favorites Scan
  • Levels of 8-Isoprostane in Serum of Patients with Bronchial Asthma

    Objective To investigate levels of 8-isoprostane in serum of patients with bronchial asthma. Methods Eighteen patients diagnosed with acute exacerbation of asthma were enrolled as the experimental group from Department of Respiratory Medicine from February 2009 to August 2009. After treatment all the patients reached remission. Twenty healthy workers from Department of Respiratory Medicine were enrolled as the control group in August 2009. The levels of 8-isoprostane in serum of all subjects were measured, and their FEV1% pred was also evaluated. Results The levels of 8-isoprostane in serum were significantly higher in patients with acute exacerbation of asthma compared with those in remission stage and the healthy control group [ ( 157. 46 ±46. 99) pg/mL vs. ( 43. 52 ±13. 62) pg/mL and( 15. 23 ±1. 96) pg/mL, P lt;0. 01] . Meanwhile the levels of 8-isoprostane in serum of patients with asthma in remission stage were significantly higher compared with the healthy control group ( P lt;0. 05) . The levels of 8-isoprostane in serum were negatively correlated with FEV1% pred in the asthma group( r = - 0. 533,P lt;0. 05) . Conclusions 8-isoprostane as amarker of oxidative stress response involves in the pathogenesis of asthma. Monitoring 8-isoprostane levels in serum may reflect the state of oxidative stress, and may be useful for severity judgment and follow-up of treatment effectiveness in patients with asthma.

    Release date:2016-08-30 11:54 Export PDF Favorites Scan
  • Clinical Analysis Of 27 Cases with Dermatomyositis and Polymyositiswith PulmonaryInvolvement

    Objective To analyze the clinical characteristics of dermatomyositis ( DM) and polymyositis ( PM) with pulmonary involvement. Methods A retrospective study was performed in 27 DM/PM patients with pulmonary involvement, who were admitted to the First People’s Hospital of Kunming fromJanuary2001 to December 2009. The clinical manifestation, laboratory examination, chest high resolution CT ( HRCT) , pulmonary function test, treatment efficacy and prognosis were analyzed. Results In 27 DM/PM patients with pulmonary involvement, pulmonary manifestations occurred in 23 cases, such as cough ( 44% ) , expectoration ( 30% ) , and dyspnea ( 11% ) . Erythrocyte sedimentation rate, creatine kinase, C-reactive protein, and lactic dehydrogenase were significantly increased in 63% , 67% , 56% , and 44% of patients. Anti-Jo-1 antibody was positive in eight cases ( 29% ) . The electromyogram ( EMG) revealed myogenic changes in all patients. Pulmonary interstitial changes were the predominant HRCT manifestations. Pulmonary function test revealed mainly restrictive ventilation dysfunction and decreased diffusion capacity. Most patients had a good prognosis by glucocorticoid treatment. Conclusions For patients with DM/PM, especially who present nonspecific pulmonary symptoms, chest HRCT and pulmonary function test should be recommended as early screening tools.

    Release date:2016-08-30 11:56 Export PDF Favorites Scan
  • 水胶体敷料预防大量输液所致静脉炎的效果研究

    目的:观察水胶体敷料外敷对预防大量静脉输液(其中含刺激性的药物)引起静脉炎的效果。方法:将80 例女性胰腺炎患者随机分为对照组(40 例)和试验组(40 例),两组均采用常规留置针穿刺,试验组在穿刺成功固定后,在距静脉穿刺点2 cm处沿血管走向用4 cm× 6 cm水胶体敷料贴于皮肤表面。对照组未用水胶体敷料,两组留置针保留时间均为3 天。结果:对照组与试验组Ⅰ级静脉炎发病率分别为72.5% 和22.5%,差异有统计学意义(P lt; 0.05)。结论:水胶体敷料外敷,能有效预防大量输液所致静脉炎的发生,减轻患者痛苦。

    Release date:2016-09-08 10:00 Export PDF Favorites Scan
  • 循证医学与知识转化

    循证医学研究的结论日益增多,如何对其结论进行综合利用是研究者面临的问题。知识转化是指知识在研究者和用户构成的一个相互作用的复杂系统内,进行交换、合成和合乎伦理的应用,通过改善健康、改进服务、提高产品质量以及加强卫生保健系统来加速各方从研究中获益的过程。循证医学与知识转化关系紧密,现对其进行简要阐述。

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  • 纳吸棉在慢性中耳炎术后填塞中的临床观察

    目的探讨纳吸棉在慢性中耳炎术后填塞中的效果,为临床耳科手术填塞物的选择提供依据。 方法将 2012年 4月-2013年 1月住院接受同一医疗组医生手术治疗的 200 例慢性中耳炎患者,根据入院时间分为对照组和试验组,对照组采用碘仿纱条材料填塞术耳腔,试验组采用纳吸棉材料填塞术耳腔,观察两组患者术后 48 h内术耳疼痛、渗血量,首次抽取填塞物时术腔出血及疼痛情况。 结果试验组患者术后 48 h 内术耳疼痛、首次抽取填塞物时的疼痛及出血情况均低于对照组,两组比较差异均有统计学意义(P<0.05);两组患者术后 48 h内术耳渗血情况差异无统计学意义(P>0.05)。 结论慢性中耳炎术后应用纳吸棉填塞术腔能提高患者舒适度,减少抽取填塞物时对术耳的损伤,促进术耳康复。

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  • 腮腺肿瘤术中保留耳大神经分支的临床分析

    目的分析腮腺肿瘤手术中保留耳大神经分支的临床效果。 方法回顾2011年7月-2013年6月63例腮腺肿瘤手术中耳大神经保留及术后术区皮肤感觉随访情况。63例患者中行耳大神经分支保留手术55例,其中保留耳大神经耳后支7例,保留耳后及耳垂支41例,保留耳前、耳垂及耳后三大主要分支7例;8例未保留耳大神经。 结果未保留耳大神经患者术后耳垂及耳垂周围皮肤长期麻木。保留耳大神经分支的55例患者中49例出现暂时性术区皮肤感觉减退,1~3个月恢复正常,6例术后耳后乳突区、耳垂几乎无明显麻木。 结论腮腺肿瘤术中保留耳大神经分支,可避免或减轻患者术区麻木、提高患者术后生活质量。保留耳垂及耳后分支具有手术操作可行性,疗效确切。

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  • 清热化痰法治疗慢性阻塞性肺疾病急性加重期的研究进展

    慢性阻塞性肺疾病(COPD)是临床多发病,急性加重期的有效防控是疾病预后的关键所在。中医对COPD有较好的治疗效果,其中清热化痰法是主要的治疗方法,现就清热化痰法近年在COPD的治疗研究作一综述。

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  • An Evidence-based Evaluation on Orphan Drug Policies

    ObjectiveTo learn the development and implementation of orphan drug policies, in order to provide decision-making references for the establishment of orphan drug policy according with China's national conditions. MethodsWe electronically searched databases including CBM, CNKI, VIP, EMbase, PubMed, Web of Knowledge, National Library of Medicine, CRD database, The Campbell Library, The Cochrane Library and the drug administration websites of USA, Canada, UK, Ireland, the Netherlands, Germany, Spain, France, Australia, New Zealand, China, India, South Korea, Japan, and South Africa to collect studies about orphan drug policy. The search date was up to February 2014. Two reviewers independently screened literature, and extracted data. Then, all included orphan drug policies were summarized and a comparative analysis was performed. ResultsA total of 110 studies were included. USA, Singapore, Japan, Australia, European Union, Chinese Taiwan and South Korea had introduced orphan drugs incentive policies. South Africa, India, Canada, New Zealand and Chinese Hongkong were producing orphan drugs policy frameworks. The main items of orphan drug policy included marketing exclusivity, tax incentives, technical assistance, grant funding, expedite approval process and prolong re-evaluated time. ConclusionIn mainland China, there is no orphan disease management policy. China should establish specific organization and working procedures, promote orphan drug policy related legislative work, clarify the definition and prevalence of orphan diseases, provide incentive mechanism to promote the research and development of orphan drugs, provide enterprises to develop compensation mechanism to safeguard the rights and interests of patients, as well as establish patients register network platform to track the processes of the diseases.

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