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find Author "陈瑞英" 3 results
  • Invasive aspergillosis in nonneutropenic patients:risk factors,clinical features and outcome

    Objective To investigate the risk factors,clinical features and outcome of invasive aspergillosis(IA) in nonneutropenic patients.Methods Fifty-four patients with IA at the First Affiliated Hospital of Zhengzhou University from Jan 2001 to Dec 2006 were analyzed retrospectively.According to the definitions of EORTC/MSG,proven diagnosis was made in 9 cases,probable diagnosis in 30 cases and possible diagnosis in 15 cases.Results In the neutropenic group(n=24),hematological malignancies were the major underlying conditions(n=20).In nonneutropenic group(n=30),the main underlying condition was steroid-treated COPD(n=11).Fever,dyspnea,cough,chest pain and haemoptysis were commonly symptoms.Thoracic computed tomography showed that segmental consolidation occurred more frequently in neutropenic patients,whereas diffuse nodules more frequently in nonneutropenic patients.Nodules or consolidation with evidence of cavity lesion had a higher sensitivity than the halo sign or air crescent sign in both groups.The total mortality of IA was 72.2%.The mortality of nonneutropenic group was higher than that of neutropenic group(83.3% vs 58.3%,P=0.042).Multivariate analysis showed that secondary central nerves system IA and delayed diagnosis were associated with poor outcome of IA.Conclusion There were high incidence and mortality of IA among nonneutropenic patients,especially those with COPD treated with long-term corticosteroids.

    Release date:2016-09-14 11:56 Export PDF Favorites Scan
  • Missed Diagnosis of Sleep Apnea Hypopnea Syndrome: Analysis of 42 Cases and Literature Review

    Objective To analyze the causes of missed diagnosis of sleep apnea hypopnea syndrome ( SAHS) . Methods 42 missed diagnosed cases with SAHS from May 2009 to May 2011 were retrospectively analyzed and related literatures were reviewed. Results The SAHS patients often visited the doctors for complications of SAHS such as hypertension, diabetes mellitus, metabolic syndrome, etc. Clinical misdiagnosis rate was very high. Lack of specific symptoms during the day, complicated morbidities, and insufficient knowledge of SAHS led to the high misdiagnosis rate and the poor treatment effect of patients with SAHS. Conclusion Strengthening the educational propaganda of SAHS, detail medical history collection, and polysomnography monitoring ( PSG) as early as possible can help diagnose SAHS more accurately and reduce missed diagnosis.

    Release date:2016-09-13 04:00 Export PDF Favorites Scan
  • 坏死性肉芽肿性血管炎一例误诊分析并文献复习

    坏死性肉芽肿性血管炎( necrotizing granulomatous vasculitis, NGV) 是一种病因未明的系统性血管炎[ 1] , 临床上分全身型和局限型[ 2 ] 。全身型以上、下呼吸道和肾脏为常见受累器官, 无肾脏受累者则为局限型。该病男性略多于女性, 40 ~50 岁为高发年龄段。因其临床表现多样, 且无特异性, 常误诊为各亚专科疾病[ 3 ] 。2012 年11 月6 日, 郑州大学第一附属医院呼吸及睡眠科收治1 例青年女性NGV患者, 现结合文献复习如下。

    Release date:2016-09-13 03:54 Export PDF Favorites Scan
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