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find Author "陈秀兰" 2 results
  • 慢性重型肝炎相关检测指标改变与预后的分析

    【摘要】 目的 总结凝血酶原活动度(PTA)、凝血酶原时间的国际标准化比值(INR)、白蛋白(ALB)、总胆红素(TB)、丙氨酸氨基转移酶(ALT)、胆碱酯酶(CHE)、总胆固醇(TC)、总胆汁酸(TBA)、血清谷草转氨酶与血清谷丙转氨酶的比值(AST/ALT)与慢性重型肝炎(CSH)预后的关系。 方法 选择2007年1月-2010年3月收治的56例CSH患者,依据病情转归,分为存活组(35例)和死亡组(21例)。比较两组PTA、INR、ALB、Tb、ALT、CHE、TCH、TBA、AST/ALT。 结果 死亡组PTA、INR、CHE、TC较存活组降低(P值均lt;0.05), TB、TBA、AST/ALT较存活组升高(P值均lt;0.05),ALT、ALB较存活组差异无统计学意义(Pgt;0.05)。 结论 PTA、INR、CHE、TC、TB、TBA、AST/ALT水平可作为CSH预后的判定指标,ALT、ALB与CSH预后无明显关联。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • Clininal analysis of immune checkpoint inhibitor-related pneumonia in patients with lung cancer

    Objective To analyze the clinical features of immune checkpoint inhibitor-related pneumonia (CIP) in patients with lung cancer. Methods The case data of patients with CIP admitted to Zhongshan Hospital of Fudan University from January 2017 to December 2020 were retrospectively collected, and the basic data, clinical manifestations, imaging data, laboratory examination results, treatment and prognosis of the patients were analyzed. Results The ratio of male to female was 18:1, and the median age was 65 years (from 41 to 74 years). Fourteen patients received a programmed death protein-1 (PD-1) inhibitor and five patients received a programmed death protein-ligand-1 (PD-L1) inhibitor. The median time to CIP was 3.5 months. The respiratory symptoms of 15 patients were dyspnea in 11 cases, cough in 9 cases, chest tightness in 8 cases, fever in 4 cases, expectoration in 4 cases and hemoptysis in 2 cases. Chest CT findings mainly showed interstitial pneumonia, including 8 cases of implicit organizational pneumonia (COP), 7 cases of non-specific interstitial pneumonia (NSIP), 2 cases of acute interstitial pneumonia, and 2 cases of allergic pneumonia. C-reactive protein, erythrocyte sedimentation rate and lactate dehydrogenase were higher in CIP than before, and the difference was statistically significant. Follow-up observation was performed in 3 patients alone, 14 patients were treated with glucocorticoid alone, 2 patients were treated with immunosuppressant therapy, 19 patients had stable or more absorption of pneumonia lesions, and 5 patients had restarted immunotherapy. There were no deaths from CIP. Conclusions CIP mainly occurs in men, with slow onset, lack of specificity in clinical manifestations, and increased inflammatory indicators. Imaging findings are mainly NSIP and COP changes. Early identification, diagnosis and rational application of glucocorticoid therapy have good effects.

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