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find Author "陈邓" 2 results
  • Investigation and analysis of status and risk factors of comorbid anxiety and depression in patients with epilepsy in West China

    Objective To investigate the prevalence of anxiety and depression in patients with epilepsy (PWE) in West China, and to explore the related risk factors. Methods The Chinese version of Generalized Anxiety Disorder (GAD)-7 and Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) scales were used to evaluate the anxiety and depression in 176 PWE patients between December 2016 and February 2017. Univariate analysis was used to screen the factors that may cause anxiety and depression in PWE, and then logistic regression analysis was performed on the possible risk factors. Results In the 176 PWE, about 27.3% had anxiety, and about 28.4% had depression. Multivariate logistic regression analysis showed that seizure occurrence in the recent six months [odds ratio (OR)=3.481, 95% confidence interval (CI) (1.292, 9.380),P=0.014], seizure occurring more than once in a month [OR=3.231, 95%CI (1.468, 7.111),P=0.004], and focal seizures with conscious disorders [OR=2.416, 95%CI (1.082, 5.397),P=0.031] were risk factors for anxiety in PWE. Unmarried status [OR=0.428, 95%CI (0.195, 0.940),P=0.035], seizure occurring more than once in a month [OR=2.685, 95%CI (1.206, 5.979),P=0.016], focal seizures with conscious disorders [OR=2.541, 95%CI (1.112, 5.808),P=0.027] and seizure occurrence in the last six months [OR=7.582, 95%CI (2.416, 23.794),P=0.001] were risk factors for depression in PWE. Conclusions Anxiety and depression are common comorbidities in PWE. For patients with risk factors, early identification and intervention should be performed.

    Release date:2017-05-18 01:09 Export PDF Favorites Scan
  • 抗体介导的自身免疫性脑炎患者的癫痫特点

    越来越多的自身免疫性脑炎(Autoimmune encephalitis,AE)患者的资料显示,其临床表现和结局的特异性依赖于患者脑脊液、血清中特定抗原的抗体。这些特异性包括了癫痫相关的临床表现及对抗癫痫药物的反应。虽然学者们对这一类疾病的研究热情不断增加,且发现了新的抗体和相关的临床综合征,但仍有一些问题需要进一步解答。首先,鉴于每一种自身免疫性抗体介导的综合征的严重程度、患者特点、治疗时间不尽相同,治疗需要个体化;其次,缺乏随机对照试验是形成适当的免疫治疗策略的重大障碍。文章就一些已阐明的 AE 患者的癫痫诊断和治疗方面的新进展和挑战作一综述,并阐述在这一新兴领域中合理应用精确药物的原则。

    Release date:2020-07-20 08:13 Export PDF Favorites Scan
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