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find Author "陈铌" 5 results
  • Clinical features and treatment of central nervous system embryonal tumor, not otherwise specified

    ObjectiveTo review the clinical records of patients with central nervous system (CNS) embryonal tumors, not otherwise specified (NOS); and summarize their clinical features, diagnosis, and treatment.MethodWe reviewed the data of patients with intracranial tumors admitted to Department of Neurosurgery of West China Hospital, Sichuan University from January 2014 to December 2016, and retrospectively analyzed the clinical features, diagnosis, and treatment of seven patients with CNS embryonal tumors, NOS.ResultsThere were 4 males and 3 females, and the mean age was 25.4 years old. The tumor was located in cerebral hemisphere in 5 patients, and in third ventricle in 2. Clinical presentation included headache, nausea, and vomiting due to intracranial hypertension, and focal neurological signs. All patients underwent craniotomy for tumor resection and postoperative pathology confirmed CNS embryonal tumor, NOS. The patients were followed up for 6 months to 3 years, and 2 patients died during follow-up.ConclusionsCNS embryonal tumor, NOS is malignant intracranial lesion, and has been enlisted as a separate entity under classification of CNS embryonal tumors. It has its unique radiological features, including rare occurrence of perilesional edema, cystic changes, and clear demarcation. Through comprehensive treatment including surgical resection, chemotherapy, and radiation therapy, patients can enjoy prolonged survival and improved quality of life.

    Release date:2018-06-26 08:57 Export PDF Favorites Scan
  • 小关节焦磷酸钙沉积症的临床病理分析

    目的探讨小关节焦磷酸钙沉积症(CPPD)的临床特点、病理特征、诊断及鉴别诊断要点。 方法对2013年3月-9月收治的4例CPPD患者的临床特点及病理学特征进行总结分析。 结果光学显微镜下病灶出现明显钙化伴不定形及晶体物质沉积,初诊均考虑非特异性钙化病变,经偏振光显微镜检查可见有特征性的双折光性菱形晶体确诊CPPD;其中1例合并有针状结晶,提示合并痛风。 结论CPPD较少见,普通组织形态无特异性,医生需结合病理检查(包括偏振光显微镜检查)及临床表现综合判断,以防漏诊或误诊。

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  • 前列腺软斑症病例报道和文献复习

    目的探讨前列腺软斑症的临床病理特征、诊断与鉴别诊断。 方法分析2012年7月17日就诊的1例前列腺软斑症的临床表现及病理学特征,并复习相关文献。 结果患者为老年男性,血清前列腺特异抗原升高,临床与影像检查疑为前列腺癌。穿刺活体组织检查见大片组织细胞样细胞,细胞质丰富、浅染;细胞内、外可见特征性的Michaelis-Gutmann小体,von Kossa钙染色、普鲁士蓝铁染色和高碘酸希夫染色阳性。 结论前列腺软斑症较少见,临床、影像与病理学上均要与前列腺癌鉴别,知晓该病并熟悉其病理特征是正确诊断的关键。

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  • 肾球旁细胞瘤的临床病理观察

    目的探讨肾球旁细胞瘤的临床病理特征、诊断与鉴别诊断。 方法对于2012年11月21日就诊的1例肾球旁细胞瘤的临床表现、病理改变和超微结构改变进行观察分析并作文献复习。 结果患者临床表现为高血压、高肾素血症、高醛固酮血症和低血钾。左肾实质内见一巨大肿瘤,行左肾切除术。光学显微镜下见形态一致的多边形或圆形肿瘤细胞呈片状、巢团状或围血管生长,可见血管外皮瘤样构像;免疫组织化学呈CD34弥漫阳性,平滑肌肌动蛋白局灶阳性,广谱细胞角蛋白、上皮细胞膜抗原、S-100、人黑色素瘤特异性抗体、嗜铬素A、突触素均阴性;透射电子显微镜下可见特征性菱形晶体(前肾素颗粒), 确诊为肾球旁细胞瘤。 结论肾球旁细胞瘤是少见的肾脏肿瘤,易误诊为其他肿瘤,知晓该病并熟悉其组织病理学和超微结构特征是正确诊断的关键。

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  • Expression of fumarate hydratase in multiple leiomyoma of the uterus

    Objective To investigate the expression and clinicopathological features of fumarate hydratase (FH) in multiple leiomyoma of the uterus. Methods Relevant clinicopathological data of patients with multiple leiomyoma of the uterus diagnosed pathologically between September 1, 2018 and August 31, 2019 were collected from the Department of Pathology of West China Second University Hospital. The morphology, FH protein expression and prognosis of FH negative patients were observed. Results A total of 900 patients were included. Among them, there were 825 cases of nonatypical leiomyomas, 36 cases of leiomyoma with bizarre nuclei, 34 cases of cellular leiomyoma and 5 cases of mitotically active leiomyoma. A total of 69 patients with negative FH expression were included, with an average age of (37.28±8.22) years. Among them, there were 43 cases of nonatypical leiomyomas, 19 cases of leiomyoma with bizarre nuclei, 6 cases of cellular leiomyoma, and 1 cases of mitotically active leiomyoma. At low magnification, staghorn shaped blood vessels, alveolar pattern edema, palisade distribution of smooth muscle cells and bizarre nuclei smooth muscle cells could be seen in patients with negative FH expression. At high magnification, cytoplasmic eosinophilicglobules andeosinophilic nucleolus surrounded by a halo could be seen in patients with negative FH expression. Among the 69 cases with negative FH expression, 60 cases (86.96%, 60/69) were followed up. All patients survived, of which 24 cases (40%, 24/60) recurred. Conclusion Immunohistochemically, the marker FH for multiple leiomyoma of the uterus is helpful to improve the identification of FH deficient leiomyoma in clinical work as well as early diagnosis in hereditary leiomyomatosis renal cell cancer syndrome.

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