ObjectiveTo investigate the relationship between the polymorphisms of estrogen receptor α (ERα) gene PvuⅡ, XbaⅠ and breast hyperplasia. MethodsPolymerase chain reaction-restriction fragment length polymorphism was used to detect the polymorphisms of ERα gene PvuⅡ, XbaⅠ in breast hyperplasia patients (study group, n=89) and healthy controls (control group, n=35). ResultsThe differences of the genotypic frequency and allele frequency of the ERα gene Xba Ⅰ were significant between the study group and the control group (Plt;0.05). According to analysis of the odds ratio (OR), the risk of developing breast hyperplasia for X allele carriers was 0.551 as compared with x allele carriers. But there was no significant difference for the gene polymorphism of PvuⅡ between the study group and the control group (Pgt;0.05). ConclusionThe polymorphisms of XbaⅠof ERα gene is associated with breast hyperplasia and the mutant gene increases breast hyperplasia risk.
目的 探讨男性乳腺癌的临床特点，治疗方式以及影响预后的因素。方法 对我院1987年至1998年间收治的13例男性乳腺癌的临床资料进行回顾性分析。结果 13例患者中腋窝淋巴结转移率61.5%，5年生存率为38.5%，Ⅳ期1例在1年内死亡，接受根治手术和改良根治手术的患者5年生存率分别为42.9%和40.0%。结论 男性乳腺癌预后较差，其治疗方式应根据患者的不同情况采用手术、放疗、化疗或内分泌治疗等综合治疗方法。