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find Keyword "雌激素受体" 42 results
  • Correlation between Polymorphism in Estrogen Receptor α Gene and Endometriosis in Chinese Women: A Meta-Analysis

    Objective To systematically evaluate the correlation between endometriosis (EM) in Chinese women and Xba I polymorphism in intron-1 of estrogen receptor α (ER-α) gene. Methods Such databases as PubMed, MEDLINE, The Cochrane Library (Issue 3, 2012), VIP, CBM, WanFang Data and CNKI were searched to collect case-control studies about the correlation between EM and Xba I polymorphism in intron-1 of ER-α gene. The retrieval time was from 1980 to 2012. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality, and then the meta-analysis was conducted by using RevMan 5.0 and Stata 12.0 software. Results A total of 7 studies involving 676 EM patients and 688 healthy volunteers were included. The results of meta-analyses showed that Chinese women with X/X genotype had similar risk of EM compared to those with x/x genotype (OR=0.95, 95%CI 0.58 to 1.54, P=0.82) or X/x genotype (OR=0.73, 95%CI 0.44 to 1.20, P=0.22). The allele X also showed similar risk of EM compared to the allele x (OR=1.11, 95%CI 0.93 to 1.33, P=0.25). Conclusion At present, it has not yet been found that the incidence of EM in Chinese women is related to the Xba I polymorphism in intron-1 of ER-α gene as well as the allele X. For the quantity and quality limitation of the included studies, this conclusion has to be proved by more studies.

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  • Study on the Relationship between PvuⅡ,XbaⅠ and STR Polymorphism of the Estrogen Receptor α Gene and Primary Liver Cancer

    目的:探讨西南地区雌激素受体α(estrogen receptor α,ERα)基因多态性与原性肝癌关系。方法:选择西南地区100名原发性肝癌患者为实验组,100名非肝病人群作为对照组。应用分子生物学的方法分析PvuⅡ,XbaⅠ限制性片段长度多态性(restriction fragment length polymorphism,RFLP)。同时对人雌激素受体基因上游的短串联重复序列(short tandem repeat,STR)进行纯化、克隆和序列分析,观察ERα基因多态性基因型在实验组与对照组中的基因型分布。结果:PvuⅡ和XbaⅠ限制性片段长度多态性在两组中均呈多态性分布。病例组TA13等位基因频率高于对照组,差异有显著性,TA15等位基因频率低于对照组,差异有显著性。结论:ERα基因多态性与原性肝癌有关,X等位基因可能是其危险因素,P等位基因可能是其保护因素,TA13等位基因可能是其危险因素,TA15等位基因可能是其保护因素。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • 雌激素受体阴性乳癌细胞株中Cyclin D1和Ki-67表达与细胞凋亡的关系

    本研究应用雌激素受体(ER)阴性乳癌细胞株MDAMB435s探讨在ER阴性乳癌细胞中Cyclin D1及Ki-67表达与细胞凋亡的关系。

    Release date:2016-08-28 04:47 Export PDF Favorites Scan
  • The Expression of ApoptosisRelated Gene bclx, bax and Estrogen Receptor in Primary Gallbladder Carcinoma and Its Clinical Significance

    Objective To study the relationship between the expression of apoptosisrelated gene bclx,bax and estrogen receptor (ER) in primary gallbladder carcinoma (PGC) and its clinical significance. MethodsImmunohistochemistry of labeled dextran polymer (LDP) with EnvisionTM system was used to detect ER and gene bclx and bax. ResultsThe positive rate of bclx,bax and ER were 72.3%,66.0% and 59.6% in 47 cases with primary gallbladder carcinoma and 40.0%,93.3% and 93.3% in 6 cases with gallbladder adenomahyperplastic. The expression of bax and ER in PGC was significantly lower than that in gallbladder adenomahyperplastic (P<0.05),the expression of bclx was significantly higher in PGC than that in the latter (P<0.05).The expression of bclx and ER in well differentiated PGC was significantly higher than that in moderately, poorly differentiated PGC (P<0.05); bax expression in well differentiated PGC was lower. ER and bax expression in male PGC was significantly lower than that in female PGC (P<0.01), the expression of bclx in male PGC was higher (P<0.05).ER was more highly expressed in smaller PGC than in larger one (P<0.05). ER and bax, bclx were not different between various clinical stages and ages (P>0.05,respectively). Conclusion The expression ER, apoptosisrelated gene bclx and bax have correlation with differentiation and sex in PGC, their levels shows significance in the prognosis of PGC.

    Release date:2016-08-28 05:10 Export PDF Favorites Scan
  • Estrogen Receptor Beta and Advances in Breast Cancer Research

    ObjectiveTo review recent studies on the roles of estrogen receptor β in breast cancer. MethodsThe literatures in recent years on the biological function, variant isoforms of estrogen receptor and its possible roles in breast cancer were reviewed. ResultsERβ was a new member of the superfamily of steroid receptors, it might play an important role in breast tumor genesis, tumor progression, prognosis and reaction to the endocrine therapy in breast cancer. ConclusionERβ is a new prognostic marker in breast cancer.

    Release date:2016-08-28 05:11 Export PDF Favorites Scan
  • RELATIONSHIP BETWEEN C-erb B-2 ONCOGENE OVEREXPRESSION AND ESTROGEN RECEPTOR, PROGESTIN RECEPTOR IN BREAST CANCER AND ITS PROGNOSTIC SIGNIFICATION

    The overexpression of C-erb B-2 oncogene in breast cancer was examined in 245 cases with immunohistochemical techniques.The results showed that:①Significant associations of C-erb B-2 overexpression with high histological grade (P<0.05), positive axillary node status (P<0.05), advanced clinical stage (P<0.05) and the absence of hormone receptor(P<0.05) were identified in breast cancer.②Overexpression of C-erb B-2 oncogene was related with 5-year and 10-year survival rate, and considered as a prognostic factor for breast cancer independent of axillary node status. Detection of C-erb B-2 oncogene overexpression could be arranged as a regular pathological examination in breast cancer.Combined with axillary node and estrogen receptor, progestin receptor status, the results can be used in determining the prognosis and planing the treatment programme in breast cancer.

    Release date:2016-08-29 09:16 Export PDF Favorites Scan
  • THE EXPRESSION AND CLINICAL SIGNIFICANCE OF SEX HORMONE RECEPTOR IN HEPATOCELLULAR CARCINOMA

    The level of androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) of carcinoma and pericarcinoma tissue were determined in 30 cases of male hepatocellular carcinoma (HCC) patients operated by streptavidin peroxdase conjugated method, meanwhile used 20 patients with benign liver disease as a contrast group. The results showed that the positive rate of AR in tumor tisse was 80.0%, significantly higher than that in peritumor tissue (46.7%) and liver tissue of benign diseases (40.0%), P<0.01, and there was no significantly difference between the latter two groups (P>0.05). The positive rate of ER in carcinoma tissue (43.3%) was notably lower than that in pericarcinoma tissue (80.0%), P<0.01. Statistically significantly difference wasn’t achieved in contrast with the benign diseases group (50.0%), P>0.05. The positive rate of PR had no significantly difference among the three groups (P>0.05). The authors suggest that sex hormone is related to initializing and developing of HCC by the action via its receptor, the level of AR and ER can be used as a prognosis determine index of HCC.

    Release date:2016-08-29 09:18 Export PDF Favorites Scan
  • DISTRIBUTION OF 125I-LABELED 17α-VINYLESTRADIOL-3-ACETATE IN NUDE MICE BEARING HUMAN BREAST CANCER

    Biodistribution of125I-labeled 17α-vinyestradiol-3-acetate (125I-VE2A)in nude mice bearing human breast cancer containing different estrogen receptor (ER) content was studied to understand the relation between this compound and ER and, consequently, to develop the ER imaging. Each mouse was injected with 92.5 kBq tracer from tail vein and then killed after two hours. The radioactivity uptake rate in one gram of tumor tissue and tissues from other vital organs were measured, and the radioactivity uptake ratio of tumor to nontumor tissue was also measured. Results: The radioactivity uptake rate and the radioactivity uptake ratio of tumor to nontumor tissue in ER positive tumor (MCF-7) were much higher than those in ER negative tumor (MDA-MB-231). Conclusions: This compound, IVE2A has affinity to ER positive target organ or tumor and promise the probability to define the content and site of ER in vivo or in tumor.

    Release date:2016-08-29 09:20 Export PDF Favorites Scan
  • RELATIONSHIPOFP62CmycPROTEINEXPRESSIONTOESTROGENPROGESTERONERECEPTORSINBREASTCANCERANDITSCLINICALSIGNIFICANCE

    InordertounderstandtherelationshipofP62CmycproteinexpressiontoERandPRinbreastcanceranditsclinicalsignificance,weexaminedexpressionofP62Cmycproteinin107breastcarcinomasbyusingimmunohistochemicaltechniques(LSAB).TheresultsshowedthatthepositiverateofP62Cmycproteinexpressionwas63.55%(68/107).TheoverexpressionofP62Cmycproteinrelatednegativelywithsurvival.94.00%ofthecaseswithoverexpressionofP62Cmycproteinsurvived≤5years,65.00%survivedgt;5yearslt;10yearsand21.62%survived≥10years.ThereweresignificantassociationsofP62Cmycproteinexpressionwithadvancedclinicalstage,highhistologicalgrade,andpositiveaxillarynodestatusinbreastcancer,butnorelationshipbetweenhormonereceptorsandP62Cmyc.AllofthesefindingssuggestthatoverexpressionofP62Cmycproteinmightbeanimportantprognosticfactor,andthedetectionofP62Cmycproteinmightbearrangedasaregularpathologicalexaminationinthecasesofbreastcancer.

    Release date:2016-08-29 03:18 Export PDF Favorites Scan
  • CLNICAL SIGNIFICANCE OF DETERJIATION OF ESTROGEN RECEPTOK, ESTRADIOL AND TESTOSTERONE IN GASTRIC CARCINOMATOUS TISSUE

    We determined estrogen receptor (ER), estradiol (E2) and testosterone (T) in the tissue of 50 gastric carcinomas ans 20 benign stomach diseases. The result showed that the positive rate of ER was 32.0% in gastric cancerous tissue, in which the poorly-differentiated type was higher than that of the well-differentiated type (Plt;0.05),and still higher in BorrmannⅢ、Ⅳ types than in Borrmann Ⅰ、Ⅱ types (Plt;0.01). The determination of Er is significant for the estimation of prognosis ans endocrinal therapy after operation. E2 content showed no obvious difference betweenn gastric carcinoma, benign somach diseases ans normal gastric mucose, but T level and T/E2 ratio in gastric cancer were much higher than those in benign stomach diseases and normal gastric mucosa (Plt;0.05). IT suggested that the imbalance of E2 and T contents may related the occurence of gatric carcinoma. The E2 and T level showed no obvious difference between ER+ and ER- in gastric cancerous tissue.

    Release date:2016-08-29 04:26 Export PDF Favorites Scan
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