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find Author "顾国利" 15 results
  • Medication Advancement of Gastrointestinal Polyposis in Patients with Peutz-Jeghers Syndrome

    Objective To investigate the medication advancement of gastrointestinal polyposis in patients with Peutz-Jeghers syndrome (PJS). Methods Literatures about the medication advancement on gastrointestinal polyposis of PJS were reviewed and analyzed. The recent development of targeting drugs, especially the data of cyclooxygenase-2 selective inhibitors and rapamycin, were emphatically summarized. Results With the deep investigation of PJS and application of selective drugs, the medication of gastrointestinal polyposis in cases of PJS has got more advancement. The extensive use of synthetic cyclooxygenase-2 inhibitors and rapamycin in clinic developed a new way to treat gastrointestinal polyposis of PJS. Conclusion The cyclooxygenase-2 selective inhibitors and rapamycin have the following features: noninvasive, high selectivity and good curative effects. They have splendid prospects in the clinical treatment of gastrointestinal polyposis in patients with PJS and are bring the treatment of gastrointestinal polyposis in cases of PJS into a targeting therapy phase.

    Release date:2016-09-08 10:57 Export PDF Favorites Scan
  • Correlation between Immunohistochemistry and Pathology for Lung Cancer Lymphatic Metastasis

    Objective To analyze and screen the risk factors of both immunohistochemistry and pathology for lung cancer lymphatic metastasis, and to build a mathematical model for preliminary evaluation. Methods By conducting retrospective studies, the information of lung cancer patients in the General Hospital of Air Force from 2009 to 2011 were collected. Both single and multiple unconditional logistic regression analyses were applied to screen total 27 possible factors for lymphatic metastasis. After the factors with statistical significance were selected, the relevant mathematical model was built and then evaluated by means of receiver operating characteristic (ROC) analysis. Results A total of 216 patients were included. The single analyses on 27 possible factors showed significant differences in the following 10 factors: pathological grade (P=0.00), age (P=0.00), tumor types (P=0.01), nm23 (P=0.00), GSTII (P=0.01), TTF1 (P=0.01), MRP (P=0.01), CK14 (P=0.02), CD56 (P=0.02), and EGFR (P=0.03). The multiple factors unconditional logistic regression analyses on those 10 risk factors screened 4 relevant factors as follows: pathological grade (OR=2.34), age (OR=1.02), nm23 (OR=1.66), and EGFR (OR=1.47). Then a mathematical diagnostic model was established based on those 4 identified risk factors, and the result of ROC analysis showed it could improve the diagnostic sensitivity and specificity compared with the single factor mathematical diagnostic model. Conclusion Pathological grade, age, nm23, and EGFR are related with lung cancer lymphatic metastasis, and all of them are the risk factors which have higher adjuvant diagnostic value for lung cancer lymphatic metastasis.

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  • 克罗恩病致儿童发育迟缓1例报道

    Release date:2016-09-08 10:46 Export PDF Favorites Scan
  • 原发性腹膜后脂肪肉瘤10例报道

    Release date:2016-09-08 10:25 Export PDF Favorites Scan
  • 以腹股沟疝为首发表现的腹膜假性黏液瘤1例报道

    Release date:2016-09-08 10:50 Export PDF Favorites Scan
  • Research Advance of Muir-Torre Syndrome

    【Abstract】ObjectiveTo review recent studies on Muir-Torre syndrome (MTS) and to improve the knowledge about MTS.MethodsThe literatures in recent years on clinic and gene research of MTS were reviewed.ResultsMTS was is a rare autosomal-dominant disorder characterized by the predisposition to both sebaceous tumors (or multiple keratoacanthomas) and internal malignancies. Gastrointestinal cancers were the most common kind of internal malignancies in MTS patients(61%),followed by genitourinary cancers(22%). In most cases(56%),sebaceous tumors appeared after the emergence of internal maliganancy. Both hereditary nonpolyposis colorectal cancer(HNPCC) and MTS were caused by germline mutations in the DNA mismatch repair genes. MTS patients exhibit significantly more mutations in the hMSH2 than in the hMLH1. In these cases , both internal and skin tumors showed the characteristic of high microsatellite instability(MSI).ConclusionThe presence of sebaceous tumors(or multiple keratoacanthomas) necessitates the search for internal malignancies. It is mandatory that patients with MTS, as patients with HNPCC, should be regularly followed up to search new malignancies. Evaluation and monitoring of the family members of patients are also necessary. The patients and their families should be counseled for genetic test. Sequencing the hMSH2 gene should be the prior selection of further examinations when clinical manifestations, history and laboratory tests suggest MTS.

    Release date:2016-09-08 11:53 Export PDF Favorites Scan
  • 食管下段胃底哑铃状畸胎瘤1例报道

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  • Peutz-Jeghers综合征肠道息肉恶变的临床分析

    目的探讨Peutz-Jeghers综合征肠道息肉恶变的临床诊治经验。 方法对2005~2015年期间所诊治的221例Peutz-Jeghers综合征患者中11例息肉恶变患者的临床病理资料进行回顾性分析。 结果11例PeutzJeghers综合征息肉恶变患者确诊时的中位年龄为31.36岁。行肠镜20例次,胃镜8例次,双气囊电子小肠镜19例次,胶囊内镜1例次。手术原因依次为肠梗阻、肠套叠、息肉恶变和消化道出血。癌变息肉分别位于十二指肠(4例)、小肠(4例)和结直肠(3例)。病理类型以管状腺癌(5例)和黏液腺癌(5例)最多见。本组11例患者均无手术死亡,1例术后发生腹部切口感染,经伤口换药等处置后出院。术后3例患者接受XELOX方案化疗,其余未作特殊治疗。1例术后失访,10例随访1个月至7年(中位随访期2.12年),其中4例术后1~3个月死于十二指肠癌肝肺转移、空肠腺癌肝转移和结肠癌肝肺多发转移,其余患者定期复查消化内镜或消化道造影等检查至今。 结论PeutzJeghers综合征息肉恶变患者年龄较小,早诊断、早治疗、定期复查可提高患者的检出率和临床治疗效果。

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  • 全部甲状旁腺切除加胸锁乳突肌内自体移植术治疗继发性甲状旁腺功能亢进症(附 45 例报道)

    目的 探讨全部甲状旁腺切除加胸锁乳突肌内自体移植术治疗继发性甲状旁腺功能亢进症(SHPT)的疗效及技巧。 方法 总结空军总医院普通外科 2008 年 1 月至 2016 年 5 月期间 45 例 SHPT 行全部甲状旁腺切除加胸锁乳突肌内自体移植术患者的临床资料和随访结果,对其手术前后血磷、血钙和全段甲状旁腺素(iPTH)水平以及手术并发症和远期疗效进行分析。 结果 45 例患者手术均顺利完成,平均手术时间 116 min。45 例患者共切除甲状旁腺 173 枚,其中 40 例患者各切除 4 枚甲状旁腺,3 例各切除 3 枚,2 例各切除 2 枚。术后无喉返神经损伤、出血等严重并发症发生。术后病理结果显示 173 枚甲状旁腺良性增生或腺瘤样增生,其中 1 例合并甲状旁腺癌。术后1 周、6 个月及 1 年血磷、血钙及 iPTH 水平均明显低于术前(P<0.05)。在术后 1~2 周,全部患者的骨痛、皮肤瘙痒等症状均明显好转,食欲改善。术后 1 年复发 1 例(2.22%),口服药物治疗后症状控制,未行手术治疗。 结论 全部甲状旁腺切除加胸锁乳突肌内自体移植术治疗 SHPT 在临床上是安全、有效的。

    Release date:2018-03-13 02:31 Export PDF Favorites Scan
  • 成功救治急性阑尾炎致糖尿病合并妊娠患者突发休克1例报道

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
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