【摘要】 目的 探讨SPECT及CT对鼻咽癌颅底骨侵犯的检测能力。 方法 2006年5月-2009年12月对159例经病理确诊的初治鼻咽癌患者行颅底SPECT断层显像，同期行CT检查，分别计算颅底受侵的阳性率。 结果 ①159例鼻咽癌SPECT颅底断层阳性率46.5%（74/159），CT阳性率25.2%（40/159），SPECT检测敏感性高于CT（Plt;0.001）。 ②鼻咽癌伴颅神经损害SPECT检测敏感性高于CT（P=0.004）。 结论 SPECT对鼻咽癌颅底骨侵犯的检测敏感性优于CT。【Abstract】 Objective To compare the results of single-photon emission computed tomography (SPECT) and CT in skull base invasion in nasopharyngeal carcinoma (NPC). Methods A total of 159 patients with nasopharyngeal carcinoma were examined by SPECT and CT of nasopharynx and skull base from May 2006 to December 2009. The positive rates were compared by McNemar test. Results The positive rate of skull base invasion detected by SPECT and CT were 46.5% and 25.2% respectively (Plt;0.001). SPECT appeared to be superior to CT in the detection of skull base invasion in NPC with cranial nerve palsy (P=0.004). ConclusionsThe detection ability of SPECT in skull base invasion is superior to that of CT.