Objective To investigate the prevalence and predisposing factors of gastroesophageal reflux（GER）in patients with chronic obstructive pulmonary disease（COPD）and its impacts on the frequency of COPD exacerbations.Methods 50 patients with acute exacerbation of COPD were enrolled in the study.All patients filled a modified version of clinically validated standardized Mayo Clinic GER questionnaire.Pulmonary function tests（PFT），body mass index（BMI），serum albumin，and medications were recorded.The patients were divided in to GER group（13 patients with GER symptoms longer than one year and diagnosed GER by gastroscope） and non-GER group（37 patients without GER symptoms）.Results There were no significant differences in the BMI，serum albumin，use of inhaled steroids and theophylline between the two groups.Forced expiratory volume in one second as a percentage of the predicted value（FEV1%pred）（37% vs 38.3%，P=0.608.），residual volume % predicted（123.4 % vs 137.8%，P=0.222），and residual volume to total lung capacity（139.4% vs 141.5%，P=0.798） were not significantly different between the two groups.The number of COPD exacerbations per year was significantly higher in patients with GER compared to patients without GER（4.5 vs 1.3，P=0.006）.Conclusions The severity of airflow obstruction and the hyperinflation is unlikely to contribute to the development of GER.Patients with GER experience significantly more exacerbations per year when compared to patients without GER，suggesting more highlight warrant in treatment of GER in COPD patients.
The pectoralis major myocutaneous flap was used to repair laryngopharyngeal and esophageal defect following radical excision of pharyngeal and inferior laryngeal carcinomas in 3 cases. The results were susscessful. The patients were follwedup for 6 months to 3 years. The deglutition functions were all reestablished, the general nutritional conditions were improved, and no recurrence or distant metastasis was observed. The advantages of this operative procedure were discussed.
【摘要】 目的 探讨无痛胃镜两种方式——清醒镇静和静脉麻醉下治疗食管静脉曲张或出血的可行性。 方法 2004年11月-2008年5月， 根据病情或患者要求，对13例患者行清醒镇静即静脉推注咪达唑仑+芬太尼，30例行静脉麻醉即静脉推注咪达唑仑+丙泊酚。43例患者中36例行套扎治疗，7例行1%乙氧硬化醇注射治疗。 结果 43例均成功完成治疗，急诊止血率100%（11/11），治疗后4周复查，显效24例，占55.8%，有效17例，占39.5%，无效2例，总有效率95.3%。静脉麻醉组术后遗忘度100%，清醒镇静组插镜过咽和治疗过程中发生恶心分别为76.9%、46.1%。两组患者在治疗过程中及治疗后均未发生大出血。 结论 无痛胃镜下行食管静脉曲张治疗安全、疗效确切，以硬化剂注射治疗者应采用静脉麻醉。【Abstract】 Objective To observe the effect of painless gastroscopy- conscious sedation and intravenous anesthesia on treating esophageal varices or bleeding. Methods From November 2004 to May 2008, according to the disease condition or patient′s requirements, anesthetists assessed 13 patients who underwent conscious sedation with the intravenous injection of midazolam + fentanyl; 30 patients underwent intravenous anesthesia with intravenous injection of midazolam+propofol. Thirty-six patients underwent set tie treatment, and seven underwent 1% aethoxysklerol injection therapy. Results AN of the 43 patients completed the treatment successfully, and the emergency bleeding rate was 100% (11/11). Four weeks after the treatment, 24 cases had apparent therapeutic effect, accounting for 55.8%; 17 patients had effect, accounting for 39.5%; 2 patients had no effect; the total effective rate was 95.3%. The postoperative forgotten degree of the patients in intravenous anesthesia group was 100%. The nausea rate happened during the mirrors inserting and treatment in the conscious sedation group was 76.9% and 46.1%, respectively. No hemorrhage occurred in both of the tow groups. Conclusion Painless endoscopic is safe and effective for esophageal varices. Intravenous anesthesia should be used in Sclerotherapy.