ObjectiveTo comparatively analyze risk factors that influence the postoperative recurrence and distant metastasis between Xinjiang Uygur and Han women with breast cancer. MethodsThe clinical data of Han and Uyghur women with diagnosis of breast cancer at Ⅰ-Ⅲ period were completely collected for retrospective analysis. Then logistic regression (univariate and multivariate) was performed for analyzing the risk factors that influenced recurrence and metastasis. ResultsA total of 728 patients were included. The recurrence and metastasis rates among Uyghur and Han patients 3 years after surgery were 28.4%, 9.8%, respectively, including local recurrence[11 Uyghur cases (6.5%) and 9 Han cases (1.6%)] and distant metastasis[37 Uyghur cases (21.8%) and 45 Han cases (8.0%)]. Significant differences were found between the two groups in tumour size and time from symptom occurrence to clinical visits (P<0.05). Pathological type, tumour size, axillary lymph node metastasis, clinical stage, ER and PR expression, and whether to accept a regular postoperative adjuvant therapy were associated with the recurrence and metastasis rate among the patients with breast cancer at Ⅰ-Ⅲ period (P<0.05). The results of multivariate logistic regression analysis showed that, the recurrence and metastasis rate of Uyghur patients was higher than that of Han patients with a significant difference (P<0.01). Pathological type, tumour size, and axillary lymph node metastasis number were the risk factors used to predict postoperative recurrence and metastasis among Uygur and Han patients; while ER positive expression, adjuvant radiation and postoperative chemotherapy were protective factors. ConclusionThe recurrence and metastasis rate of Uyghur patients with breast cancer is higher than that of Han patients. Pathological type, tumour size, and axillary lymph node metastasis number are the risk factors of postoperative recurrence and distant metastasis; while ER positive expression, adjuvant radiation and postoperative chemotherapy may inhibit the recurrence and distant metastasis of breast cancer.
【Abstract】 Objective To investigate the effectiveness of pedicled sternocleidomastoid muscle flap in repairing defect after parotidectomy by comparing with direct suture. Methods The clinical data were retrospectively analyzed, which were from 73 patients with parotid tumor undergoing parotidectomy between January 2002 and April 2010. After parotidectomy, defects were repaired with pedicled sternocleidomastoid muscle flap in 38 cases (flap group) and with direct suture in 35 cases (control group). There was no significant difference in gender, age, disease duration, tumor location and size between 2 groups (P gt; 0.05). Meanwhile the complications, such as local introcession deformity, Frey’s syndrome and parotid gland fistula were observed. Results In flap group, the flaps were all alive and incisions healed by first intention; in control group, all incisions healed by first intention. All patients were followed up 6-98 months and no tumor recurred. There was significant difference in local introcession deformity between 2 groups (χ2=53.202, P=0.000). The parotid gland fistula was found in 1 case (2.6%) of the flap group and in 8 cases (22.8%) of the control group, Frey’s syndrome was found 1 case (2.6%) of the flap group and in 20 cases (57.1%) of the control group, showing significant differences between 2 groups (P lt; 0.05). Conclusion The use of pedicled sternocleidomastoid muscle flap for defect repair after parotidectomy can avoid the complications of local introcession deformity, Frey’s syndrome, and parotid gland fistula.