1术后生存41年，肝癌治疗史上的奇迹肝癌在我国是最常见的癌症之一，每年约10万人被夺去生命。此病进展迅速，预后很差，人们常将其称为“癌中之王”，或“不治之症”。 近年，肝癌研究不断取得突破进展，振奋人心。其中印象最深的是，复旦大学附属中山医院(原上海医科大学附属中山医院)在41年前为一肝癌患者成功施行了肝切除手术，至今已91岁高龄，仍健在。创造了肝癌外科治疗史上的奇迹。
Two hundred and thirty patients with solid hepatic space-occupying lesions (SHSOL), on whom hepatic resection was performed in Zhongshan hospital, were analyzed. We found that liver cirrhosis could be a diagnostic marker of hepatocellular carcinoma in patients with SHSOL, for which the sensitivity being 85.2%, the specificity 96.3%, and the positive predictive value 98.7%.
目的报告8例肝血管平滑肌脂肪瘤的影像学特征及病理学特点，探讨其诊断与治疗方法。方法对8例经手术及病理证实的肝血管平滑肌脂肪瘤的术前影像学表现（B超、CT、MRI、99mTcPMT）、手术情况及病理特点进行分析。结果B超： 肿瘤呈强回声光团6例，低回声光团2例； 边界清楚7例，血供丰富、内部回声不均匀4例，其中1例内部呈分隔网状结构。彩色Doppler超声示肿瘤血供丰富，均测及动脉频谱，阻力指数为0.4～0.5。静脉造影示肿瘤内血流信号明显增加。CT： 平扫示肿瘤呈低密度影7例，不均匀5例，边界清楚7例，肿瘤内见软组织影2例，脂肪成分2例。增强扫描示动脉期明显强化，门脉期及延迟期逐渐呈低密度。MRI: 肿瘤呈短T1、长T2信号，增强后强化明显，脂肪抑制后短T1变成长T1。99mTcPMT示肿瘤呈放射性增强，5 min相肿块区呈放射性缺损，2 h、5 h延迟相肿块区未见放射性填充，肝血池相肿块呈放射性填充。病理及免疫组化： 肿瘤由成熟的脂肪、血管及平滑肌组成，HMB45阳性。术前确诊3例。结论B超示强回声光团，CT呈低密度影中出现软组织影、脂肪成分，增强明显，MRI出现脂肪信号，脂肪抑制后短T1变成长T1，增强明显。99mTcPMT示肿瘤呈放射性增强，5 min相呈放射性缺损，延迟相未见放射性填充，肝血池相呈放射性填充。这些是肝血管平滑肌脂肪瘤的影像学特点，结合病史可作出诊断。此病应尽早手术治疗，行肝部分切除术。最后确诊依靠病理检查及免疫组化分析。
Objective To report the authors’ own experience and results of recent studies of anatomical liver resection for patients with hepatocellular carcinoma (HCC). Methods From January 2004 to June 2005, anatomical liver resection procedure were completed in 93 patients with HCC. Surgical techniques were designed to reduce intraoperative blood loss, blood transfusion and postoperative complications by parenchymal crushing with kelly forceps, inflow and outflow selective clamping. In 13 patients with large liver tumors, liver hanging maneuver performed in the course of hemihepatectomy. Liver transection with intermittent closure of the blood influx to the liver, using a Pringle manoeuvre. Results Of 93 patients undergoing hepatectomy for HCC, underlying cirrhosis was present in 82 (88%) patients. The median blood loss was 300 ml (100－6 000 ml) and 71%（66/93） of the patients did not require blood transfusion.The postoperative complication rate was 34%（32/93）, complications were primarily subphrenic collection (8 cases). Within 30 postoperative days, no death was recorded. Conclusion The anatomical liver resection of HCC may be improve the surgical outcome.