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find Keyword "骨折延迟愈合" 2 results
  • 高压氧治疗胫骨中下段骨折愈合延迟的疗效观察

    目的 探讨使用高压氧辅助治疗胫骨中下段骨折愈合延迟的疗效观察。 方法 选取 2013 年 3 月—2015 年 7 月骨科收治的胫骨中下段骨折愈合延迟患者 46 例,将患者随机分为对照组及试验组,每组各 23 例。对照组行骨科常规处理;试验组在骨科常规处理基础上行压力为 2.5 个绝对大气压的高压氧治疗;并根据放射骨痂评定方法,于治疗前及治疗后 8、16、32 周对两组患者进行 4 次骨痂评分,并于 1 年后依患肢恢复情况评定疗效。 结果 治疗前及治疗后 8 周两组患者的骨痂评分比较,差异均无统计学意义(P>0.05);治疗后 8、16、32 周时两组骨痂评分均优于治疗前,且治疗后 16、32 周试验组评分均优于对照组,差异均有统计学意义(P<0.05)。治疗 1 年后,试验组的痊愈率[56.5%(13/23)]和治疗总有效率[91.3%(21/23)]优于对照组[26.1%(6/23)和 65.2%(15/23)],差异有统计学意义(P<0.05)。 结论 高压氧治疗胫骨中下段骨折愈合延迟能显著促进断端骨痂生长,提高治愈率。

    Release date:2017-11-24 10:58 Export PDF Favorites Scan
  • Effectiveness of percutaneous injection of autologous concentrated bone marrow aspirate combined with platelet-rich plasma in treatment of delayed fracture healing

    ObjectiveTo analyze the effectiveness of percutaneous injection of autologous concentrated bone marrow aspirate (cBMA) combined with platelet-rich plasma (PRP) in the treatment of delayed fracture healing.MethodsA prospective, randomized, controlled, single-blind case study was conducted. Between March 2016 and July 2018, 66 patients who met the inclusion and exclusion criteria for delayed fracture healing but had solid internal fixation of the fracture end were randomly divided into control group (31 cases, treated with percutaneous autogenous bone marrow blood injection) and study group (35 cases, treated with percutaneous autogenous cBMA+PRP injection). General data such as gender, age, body mass index, site of delayed fracture healing, length of bone defect at fracture end, and preoperative radiographic union score for tibia (RUST) showed no significant difference between the two groups (P>0.05). Before injection, Kirschner wire was used in both groups to stimulate the fracture end and cause minor injury. The fracture healing time, treatment cost, and adverse reactions were recorded and compared between the two groups. Visual analogue scale (VAS) score was used to evaluate pain improvement. The tibial RUST score was extended to the tubular bone healing evaluation.ResultsNo infection of bone marrow puncture needle eyes occurred in both groups. In the control group, local swelling was obvious in 5 cases and pain was aggravated at 1 day after operation in 11 cases. In the study group, postoperative swelling and pain were not obvious, but 2 cases presented local swelling and pain. All of them relieved after symptomatic treatment. Patients in both groups were followed up, the follow-up time of the control group was 16-36 months (mean, 21.8 months), and the study group lasted 14-33 months (mean, 23.2 months). The amount of bone marrow blood was significantly lower in the study group than in the control group (t=4.610, P=0.000). The degree of postoperative pain in the study group was less than that in the control group, and the treatment cost was higher than that in the control group. But the differences between the two groups in VAS score at 1 day after operation and treatment cost were not significant (P>0.05). Fracture healing was achieved in 19 cases (61.3%) in the control group and 30 cases (85.7%) in the study group. The difference in fracture healing rate between the two groups was significant (χ2=5.128, P=0.024). Fracture healing time and RUST score at last follow-up were significantly better in the study group than in the control group (P<0.05). At last follow-up, RUST scores in both groups were significantly improved when compared with those before operation (P<0.05).ConclusionAutogenous cBMA combined with PRP percutaneous injection can provide high concentration of BMSCs and growth factors, and can improve the fracture healing rate and shorten the fracture healing time better than autogenous bone marrow blood injection.

    Release date:2020-09-28 02:45 Export PDF Favorites Scan
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