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find Author "鲜述彦" 2 results
  • Effect of Epristeride on 5-Alpha-Reductase Activity and Androgen Receptor Level in Prostate Tissue

    Objective To investigate the effect of epristeride on 5-alpha-reductase activity and androgen receptor levels in prostate tissue. Methods Forty patients with benign prostate hyperplasia were randomly divided into the trial group and the control group with 20 in each group. Patients in the trial group were administered oral epristeride and terazosin, while those in the control group were given just terazosin. All patients underwent trans-urethral resection of the prostate after two weeks, and then the 40 samples of prostate were tested immunohistochemically for 5-alpha-reductase activities and androgen receptor levels. Results The 5-alpha-reductase in prostate tissue was not stained or lightly stained in the trial group, while it was heavily stained in the control group. The androgen receptor in prostate tissue was heavily stained in both groups. Conclusion  Oral epristeride can inhibit the activity of 5-alpha-redutase in prostate tissue, but it has no obvious effect on the androgen receptor level in prostate tissue.

    Release date:2016-08-25 03:36 Export PDF Favorites Scan
  • 单纯性肾囊肿3种手术治疗效果的比较

    目的:比较和评价后腹腔镜去顶减压术、开放性去顶减压术和穿刺硬化术的治疗单纯性肾囊肿的效果。方法:138例单纯性肾囊肿者中采用后腹腔镜去顶减压术48例,开放性去顶术56例,穿刺硬化术34例。对3种术式的临床疗效、术后恢复及费用等进行对比研究。结果:3组患者在年龄、性别、侧别、随访时间及囊肿大小上差异无统计学意义。腹腔镜组症状消失者72.9%,症状好转者22.9%,无复发;开放手术组症状消失者69.6%,症状好转者26.8%,无复发;穿刺硬化组症状消失者35.3%,症状好转者58.8%,复发29.4%。腹腔镜组术后均未注射止痛剂,平均发热21d,住院35d,伤口疼痛麻木持续1.5个月;开放手术组术后39.3%(22/56)注射止痛剂,平均发热4.4d,住院5.4d,伤口疼痛麻木持续5.6个月;穿刺硬化组术后无注射止痛剂,平均发热0.2d,住院0.8d,伤口疼痛麻木持续0.5月。术后并发症发生率腹腔镜组为6.3%(3/48),主要为肾周血肿和感染;开放手术组为8.9%(5/56),主要为伤口感染、应激性溃疡等;穿刺硬化组为2.9%(1/34),主要为肾周血肿。腹腔镜组和开放手术组费用显著高于穿刺硬化手术组(Plt;0.05)。结论:腹腔镜肾囊肿去顶术疗效确切、复发率低、并发症少、费用高;开放性肾囊肿去顶术疗效确切、复发率低、并发症多、费用高;穿刺硬化术疗效确切、复发率高、并发症少、费用低。在单纯性肾囊肿的治疗中,腹腔镜手术已经成为治疗的金标准,但根据患者的病情和经济社会情况可选择开放手术和穿刺硬化手术治疗。

    Release date:2016-09-08 09:56 Export PDF Favorites Scan
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