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find Keyword "麝香保心丸" 2 results
  • 麝香保心丸治疗老年慢性充血性心力衰竭的疗效观察

    目的研究麝香保心丸治疗老年慢性心力衰竭的疗效观察及对C-反应蛋白(CRP)的影响。 方法将2010年1月-2012年1月收治的62例患者随机分为治疗组及对照组,每组31例,两组均给予一般治疗及基础药物治疗,治疗组加用麝香保心丸。治疗30 d后检测心搏出量(SV)、左心室射血分数(LVEF)、左心室收缩末期容积指数(LVESVI)、左心室舒张末期容积指数(LVEDVI)及CRP,两组进行对照比较。 结果两组患者各项指标较治疗前均显著改善,且治疗组大部分指标的改变显著高于对照组。 结论麝香保心丸能降低心肌耗氧量,增强心肌收缩力,降低血清CRP浓度,减轻炎症反应,显著改善心衰症状。

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  • Promotion of Function of Endothelial Progenitor Cells with Shexiang Baoxin Pill Treatment under Shear Stress

    The aim of this study was to investigate whether shear stress could promote function of endothelial progenitor cells (EPCs)with Shexiang Baoxin Pill (SBP) treatment in vitro, and to study whether shear stress contributed to vascular injury repair by EPCs. EPCs were isolated and characterized; EPCs' proliferation, migration, adhesion, tube formation and eNOS protein level in vitro were investigated by culturing confluent EPCs in 4 mg/mL SBP under physiological shear stress (15 dyne/cm2) for up to 24 hours. Afterwards, EPCs were transfused into rats after wire-induced carotid artery injury augmented re-endothelialization. The results showed that, compared to the SBP group, the shear stress+SBP group obviously enhanced EPCs proliferation, migration, adhesion, tube formation and eNOS protein expression in vitro (P<0.01). After one week, immunofluorescence staining showed that endothelial regeneration rate obviously enhanced in shear stress+SBP group (P<0.01). The present study demonstrates that shear stress can promote function of endothelial progenitor cells treated with SBP, which improves the vascular injury repair potentials of EPCs.

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