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find Author "黄娜" 7 results
  • BAD与肿瘤关系的研究

    【摘要】 肿瘤的发病率呈逐年攀升趋势,但其发生、发展机制仍不明确。细胞凋亡抑制可能是导致肿瘤发生、发展的重要机制。因此与凋亡通路相关的蛋白有可能成为肿瘤治疗的靶点。BAD是Bcl-2家族中的一员,属于促凋亡蛋白,现就BAD与肿瘤关系的研究作一综述。

    Release date:2016-09-08 09:27 Export PDF Favorites Scan
  • A nomogram for predicting secondary pulmonary fungal infection in patients with acute exacerbations of chronic obstructive pulmonary disease

    Objective To investigate the risk factors for secondary pulmonary fungal infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). And a visual tool using nomogram was developed and validated to assist in the clinical prediction of the probability of pulmonary fungal infection occurrence in AECOPD patients. Methods A retrospective cohort study method was used to collect AECOPD patients hospitalized in the Department of Respiratory, The First Affiliated Hospital of Chengdu Medical College from January 2021 to December 2021 as a training set. And AECOPD patients between January 2020 and December 2020 were collected as a validation set. Independent risk factors were determined through univariate, Lasso regression analyses. and multivariable logistic, A nomogram prediction model was constructed with these independent risk factors, and the nomogram was evaluated by receiver operating characteristic area under the curve (AUC), calibration curve, and decision curve analysis (DCA). Results The use of glucocorticoid, combined use of antibiotics, duration of antibiotic use and hypoalbuminemia were independent risk factors for secondary pulmonary fungal infection in AECOPD patients (all P<0.05). The training set and validation set of the constructed prediction model had an AUC value of 0.915 [95%CI: 0.891 - 0.940] and 0.830 [95%CI: 0.790 - 0.871], respectively. The calibration curve showed that the predicted probability was in good agreement with the actual observed probability of pulmonary fungal infection in AECOPD patients. The corresponding decision curve analysis (DCA) indicated the nomogram had relatively ideal clinical utility. Conclusions The result showed that the use of glucocorticoid, combined use of antibiotics, prolonged antibiotic therapy and hypoalbuminemia was independent risk factors for pulmonary fungal infection in AECOPD patients. The clinical prediction model for secondary pulmonary fungal infection in AECOPD patients constructed in this study has strong predictive power and clinical practicability.

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  • Akt与肿瘤关系的研究进展

    【摘要】丝氨酸/苏氨酸蛋白激酶B (protein kinase B, PKB/Akt)作为一种癌基因,通过磷酸化其下游分子,介导或参与细胞周期的调节、细胞生长、凋亡、增殖等多种生物学活性,从而参与肿瘤的发生、发展。这使得Akt可能成为肿瘤基因治疗、抗肿瘤药物开发新的作用靶点。现就Akt的结构、活化和调节及在肿瘤中的作用予以综述。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • 溶瘤病毒在肺癌治疗中的研究进展

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  • Analysis on Pulmonary Langerhans Cell Histiocytosis

    目的 探讨肺郎格罕细胞组织细胞增多症(pulmonary Langerhans cell histiocytosis, PLCH)的临床特征、诊断和治疗。 方法 回顾性分析1999年-2008年4例病理确诊的PLCH。 结果 4例患者均为男性;13~56岁;2例吸烟。临床特征是活动后气短、气胸。胸部CT表现为网格状、囊状或结节状影像。肺活检病理结果:光学显微镜下可见病理性郎格罕细胞,免疫组织化学法检测发现4例S-100均为阳性,2例CD1a阳性,1例CD68阳性。 结论 PLCH胸部CT表现为网结节或囊性变,病理检查见病理性郎格罕细胞浸润细支气管壁和上皮细胞的间质,免疫组织化学CD1a抗原、S-100蛋白阳性可明确诊断。

    Release date:2016-09-08 09:49 Export PDF Favorites Scan
  • Efficacy and safety of telemedicine for blood glucose and pregnancy outcomes in gestational diabetes mellitus: a systematic review

    ObjectivesTo systematically review the efficacy of telemedicine on blood glucose level and pregnancy outcomes in patients with gestational diabetes mellitus.MethodsThe Cochrane Library, PubMed, Web of Science, CINAHL, Scopus, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials (RCTs) on efficacy of telemedicine on blood glucose and pregnancy outcomes in patients with gestational diabetes from inception to January 1st, 2019. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, and then meta-analysis was performed by RevMan 5.3 software.ResultsA total of 10 RCTs involving 1 267 patients were included. The results of meta-analysis showed that there were no statistical significances in fasting blood glucose (MD=−0.34, 95%CI −1.62 to 0.93, P=0.60), HbA1c (MD=−0.22, 95%CI −0.61 to 0.17, P=0.27), gestational age at delivery (MD=0.03, 95%CI −0.13 to 0.19, P=0.72), premature rate (OR=0.52, 95%CI 0.26 to 1.01, P=0.05), caesarean delivery rate (OR=0.87, 95%CI 0.57 to 1.31, P=0.51), infant birth weight (MD=13.01, 95%CI −45.75 to 71.78, P=0.66), large for gestational age rate (OR=1.16, 95%CI 0.83 to 1.62, P=0.40), pre- eclampsia/pregnancy induced hypertension rate (OR=1.04, 95%CI 0.52 to 2.09, P=0.91), neonatal hypoglycaemia rate (OR=1.21, 95%CI 0.75 to 1.95, P=0.44) and neonatal jaundice rate (OR=1.09, 95%CI 0.59 to 2.00, P=0.78) between telemedicine management and outpatient follow-up of gestational diabetes mellitus. However, the telemedicine management group had lower 2h postprandial blood glucose (MD=−3.45, 95%CI −5.53 to −1.37, P=0.001).ConclusionsThe current evidence shows that telemedicine management of gestational diabetes mellitus achieves similar efficacy and safety in blood glucose level and pregnancy outcomes as outpatient follow-up. Due to limited quality and quantity of the included studies, more high quality studies are required to verify the above conclusions.

    Release date:2019-07-31 02:24 Export PDF Favorites Scan
  • The application of modified rhomboid flap in repairing facial skin and soft tissue defect

    ObjectiveTo explore the effectiveness of modified rhomboid flap for repairing facial skin and soft tissue defect.MethodsBetween January 2016 and May 2018, 23 patients with facial skin and soft defect were repaired by the modified rhomboid flap. There were 10 males and 13 females with the median age of 27 years (range, 11-72 years). The primary tumor included pigmented nevus in 18 cases, basal cell carcinoma in 4 cases, and squamous cell carcinoma in 1 case. The defect location was nose in 8 cases, cheek in 4 cases, malar in 6 cases, forehead in 2 cases, and upper lip in 3 cases. The defect ranged from 0.8 cm×0.8 cm to 3.9 cm×3.9 cm. According to the location and size of facial tumors, the resection area of square lesions was designed. According to the mobility of surrounding tissues and the direction of dermatoglyphic lines, the rhomboid flaps with an angle of 45–60° was designed to repair the defect by tension-free rotation.ResultsAll the flaps survived and the incision healed by first intension. All patients were followed up 3-15 months (mean, 7.3 months). During follow-up, no tumor reoccurred; the color and texture of the flaps were similar with surrounding tissue. There was no obvious scar hyperplasia, nor traction of adjacent normal tissues, and patients were satisfied with the appearance.ConclusionThe application of modified rhomboid flaps in repairing facial skin and soft tissue defects caused by resection of round facial tumor has the advantages of flexible design, simple manipulation, and less trauma.

    Release date:2019-01-25 09:40 Export PDF Favorites Scan
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