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find Author "黄文博" 2 results
  • Analysis of transcriptomic differences of duodenal neuroendocrine tumor accompanied by liver and lymph node metastases

    ObjectiveTo explore the key genes and potential molecular mechanisms of liver and lymph node metastases relevant to duodenal neuroendocrine tumors (DNET). MethodsThe tissues of paracancerous duodenal epithelial, primary lesion, liver metastasis lesion, and lymph node metastasis lesion of a rare DNET accompanied by liver and lymph node metastases were sequenced and analyzed. The differentially expressed genes (DEGs) were screened for different tissues and the functional enrichment analysis was performed. ResultsThe tissues of paracancerous duodenal epithelial was used as the control, a total of 2 053 DEGs expressed only in the liver metastases lesion tissues and 742 DEGs expressed only in the lymph node metastases lesion tissues were screened out, and the top 5 genes expressed in the liver metastases lesion tissues were ORM1, C4BPA, AHSG, C9, and LBP, which in the lymph node metastases lesion tissues were ABHD12B, AC100850.1, HOXC9, AC083967.1, and HOXC8. Kyoto Encyclopedia of Genes and Genomes enrichment analysis found that the DEGs were mainly enriched in the phosphatidylinosiol 3 kinase / protein kinase B pathway, mitogen-activated protein kinase pathway, human papillomavirus infection, etc. ConclusionMultiple DEGs and pathways in metastatic lesions are found in this patient with DNET accompanied by liver metastasis and lymph node metastasis, which provides a new direction for treatment and prophylaxis of DNET.

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  • 局部进展期中低位直肠癌新辅助治疗对淋巴结检出数目的影响及预后分析

    目的分析接受新辅助治疗的局部进展期中低位直肠癌患者在根治性切除术中可能影响淋巴结检出数目的因素,并分析淋巴结检出数目对预后的影响。方法回顾性分析2016年3月至2021年12月期间西安交通大学第一附属医院收治且接受新辅助治疗联合根治性手术的局部进展期中低位直肠癌患者的临床病理资料,采用线性回归模型筛选影响淋巴结检出数目的因素,Kaplan-Meier法绘制生存曲线。结果共收集到81例局部进展期中低位直肠癌根治性切除术患者,淋巴结检出数目(12.11±5.54)枚/例;检出淋巴结平均数目 <12枚者42例、≥12枚者39例。多因素线性回归模型分析结果显示,男性患者和联合新辅助放疗可降低检出淋巴结数目的概率(分别为:t=–3.17,P=0.002;t=–2.44,P=0.017)。以检出淋巴结平均数目12枚为截点分析 <12枚和 ≥12枚患者的Kaplan-Meier法绘制的生存曲线,经log-rank检验发现,检出淋巴结平均数目 <12枚和 ≥12枚患者的总生存和无病生存曲线比较差异均无统计学意义(分别为:χ2=0.107,P=0.743;χ2=0.027,P=0.870)。对64例临床区域淋巴结阳性患者将淋巴结检出数目平均6~13枚分别以 <6枚/≥6枚、……和 <13枚/≥13枚作为分组截点进行分层分析的结果显示,以平均7枚和8枚淋巴结检出数目作为分组截点的2组患者的累积总生存情况比较差异有统计学意义(χ2=3.977,P=0.046;χ2=3.977,P=0.046),即检出淋巴结平均数目至少7枚或8枚者的总生存情况更好。结论本研究的数据分析结果提示,男性患者和联合了新辅助放疗的患者对术后获检淋巴结数目会有一定的影响;从总体患者的生存分析看,未发现检出淋巴结数目与总生存和复发有关,但在临床区域淋巴结阳性的患者中发现,至少检出7枚或8枚淋巴结可以改善患者的预后。

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